Increased risk of atherosclerotic cardiovascular disease among patients with psoriasis in Korea: A 15-year nationwide population-based cohort study

Keum Ji Jung; Tae Gyun Kim; Jae Won Lee; Minseok Lee; Jongwook Oh; Sang Eun Lee; Hyuk Jae Chang; Sun Ha Jee; Min Geol Lee

doi:10.1111/1346-8138.15052

Increased risk of atherosclerotic cardiovascular disease among patients with psoriasis in Korea: A 15-year nationwide population-based cohort study

Keum Ji Jung, Tae Gyun Kim, Jae Won Lee, Minseok Lee, Jongwook Oh, Sang Eun Lee, Hyuk Jae Chang, Sun Ha Jee, Min Geol Lee

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19 Citations (Scopus)

Abstract

The association between psoriasis and risk of atherosclerotic cardiovascular disease has not been thoroughly evaluated in a large longitudinal cohort of an Asian population. We conducted a nationwide population-based retrospective cohort study encompassing more than 1.7 million Koreans with a 15-year follow-up period. The period prevalence of psoriasis was 0.33% among the baseline participants (1997–2000). In Cox proportional hazard analyses, the individuals with psoriasis had a higher adjusted hazard ratio (HR) for incidence of overall atherosclerotic cardiovascular disease (HR, 1.18; 95% confidence interval [CI], 1.09–1.27) compared with controls. Subgroup analyses revealed that the risk for myocardial infarction was commonly increased in both sexes with moderate to severe psoriasis (male: HR, 2.09; 95% CI, 1.35–3.24; female: HR, 3.23; 95% CI, 1.34–7.76), whereas the risk for ischemic stroke was specifically increased in female individuals with moderate to severe psoriasis (HR, 2.02; 95% CI, 1.24–3.30). Our data suggest that appropriate medical screening for possible cardiovascular comorbidities is warranted in Asian psoriatic patients according to disease severity and sex.

Original language	English
Pages (from-to)	859-866
Number of pages	8
Journal	Journal of Dermatology
Volume	46
Issue number	10
DOIs	https://doi.org/10.1111/1346-8138.15052
Publication status	Published - 2019 Oct 1

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health and Welfare (no. HI14C2686 to S. H. J. and HI17C1659 to M. G. L.), by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (no. NRF-2016R1A6A3A11933465 to K. J. J. and NRF-2017R1D1A1B03035571 to T. G. K), and by the NRF grant funded by the Korean Government (Ministry of Science and ICT (no. NRF-2018R1A2B6007818 to M. G. L.).

Publisher Copyright:
© 2019 Japanese Dermatological Association

All Science Journal Classification (ASJC) codes

Dermatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/1346-8138.15052

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title = "Increased risk of atherosclerotic cardiovascular disease among patients with psoriasis in Korea: A 15-year nationwide population-based cohort study",

abstract = "The association between psoriasis and risk of atherosclerotic cardiovascular disease has not been thoroughly evaluated in a large longitudinal cohort of an Asian population. We conducted a nationwide population-based retrospective cohort study encompassing more than 1.7 million Koreans with a 15-year follow-up period. The period prevalence of psoriasis was 0.33% among the baseline participants (1997–2000). In Cox proportional hazard analyses, the individuals with psoriasis had a higher adjusted hazard ratio (HR) for incidence of overall atherosclerotic cardiovascular disease (HR, 1.18; 95% confidence interval [CI], 1.09–1.27) compared with controls. Subgroup analyses revealed that the risk for myocardial infarction was commonly increased in both sexes with moderate to severe psoriasis (male: HR, 2.09; 95% CI, 1.35–3.24; female: HR, 3.23; 95% CI, 1.34–7.76), whereas the risk for ischemic stroke was specifically increased in female individuals with moderate to severe psoriasis (HR, 2.02; 95% CI, 1.24–3.30). Our data suggest that appropriate medical screening for possible cardiovascular comorbidities is warranted in Asian psoriatic patients according to disease severity and sex.",

author = "Jung, {Keum Ji} and Kim, {Tae Gyun} and Lee, {Jae Won} and Minseok Lee and Jongwook Oh and Lee, {Sang Eun} and Chang, {Hyuk Jae} and Jee, {Sun Ha} and Lee, {Min Geol}",

note = "Funding Information: This study was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health and Welfare (no. HI14C2686 to S. H. J. and HI17C1659 to M. G. L.), by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (no. NRF-2016R1A6A3A11933465 to K. J. J. and NRF-2017R1D1A1B03035571 to T. G. K), and by the NRF grant funded by the Korean Government (Ministry of Science and ICT (no. NRF-2018R1A2B6007818 to M. G. L.). Publisher Copyright: {\textcopyright} 2019 Japanese Dermatological Association",

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AU - Lee, Minseok

AU - Oh, Jongwook

AU - Lee, Sang Eun

AU - Chang, Hyuk Jae

AU - Jee, Sun Ha

AU - Lee, Min Geol

N1 - Funding Information: This study was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health and Welfare (no. HI14C2686 to S. H. J. and HI17C1659 to M. G. L.), by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (no. NRF-2016R1A6A3A11933465 to K. J. J. and NRF-2017R1D1A1B03035571 to T. G. K), and by the NRF grant funded by the Korean Government (Ministry of Science and ICT (no. NRF-2018R1A2B6007818 to M. G. L.). Publisher Copyright: © 2019 Japanese Dermatological Association

PY - 2019/10/1

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N2 - The association between psoriasis and risk of atherosclerotic cardiovascular disease has not been thoroughly evaluated in a large longitudinal cohort of an Asian population. We conducted a nationwide population-based retrospective cohort study encompassing more than 1.7 million Koreans with a 15-year follow-up period. The period prevalence of psoriasis was 0.33% among the baseline participants (1997–2000). In Cox proportional hazard analyses, the individuals with psoriasis had a higher adjusted hazard ratio (HR) for incidence of overall atherosclerotic cardiovascular disease (HR, 1.18; 95% confidence interval [CI], 1.09–1.27) compared with controls. Subgroup analyses revealed that the risk for myocardial infarction was commonly increased in both sexes with moderate to severe psoriasis (male: HR, 2.09; 95% CI, 1.35–3.24; female: HR, 3.23; 95% CI, 1.34–7.76), whereas the risk for ischemic stroke was specifically increased in female individuals with moderate to severe psoriasis (HR, 2.02; 95% CI, 1.24–3.30). Our data suggest that appropriate medical screening for possible cardiovascular comorbidities is warranted in Asian psoriatic patients according to disease severity and sex.

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Increased risk of atherosclerotic cardiovascular disease among patients with psoriasis in Korea: A 15-year nationwide population-based cohort study

Abstract

Bibliographical note

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UN SDGs

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