Increased risk of cardiovascular events in stroke patients who had not undergone evaluation for coronary artery disease

Young Dae Kim, Dongbeom Song, Hyo Suk Nam, Donghoon Choi, Jung Sun Kim, Byeong Keuk Kim, Hyuk Jae Chang, Hye Yeon Choi, Kijeong Lee, Joonsang Yoo, Hye Sun Lee, Chung Mo Nam, Ji Hoe Heo

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: Although asymptomatic coronary artery occlusive disease is common in stroke patients, the long-term advantages of undergoing evaluation for coronary arterial disease using multi-detector coronary computed tomography (MDCT) have not been well established in stroke patients. We compared long-term cardio-cerebrovascular outcomes between patients who underwent MDCT and those who did not. Materials and Methods: This was a retrospective study in a prospective cohort of consecutive ischemic stroke patients. Of the 3117 patients who were registered between July 2006 and December 2012, MDCT was performed in 1842 patients [MDCT (+) group] and not in 1275 patients [MDCT (-) group]. Occurrences of death, cardiovascular events, and recurrent stroke were compared between the groups using Cox proportional hazards models and propensity score analyses. Results: During the mean follow-up of 38.0±24.8 months, 486 (15.6%) patients died, recurrent stroke occurred in 297 (9.5%), and cardiovascular events occurred in 60 patients (1.9%). Mean annual risks of death (9.34% vs. 2.47%), cardiovascular events (1.2% vs. 0.29%), and recurrent stroke (4.7% vs. 2.56%) were higher in the MDCT (-) group than in the MDCT (+) group. The Cox proportional hazards model and the five propensity score-adjusted models consistently demonstrated that the MDCT (-) group was at a high risk of cardiovascular events (hazard ratios 3.200, 95% confidence interval 1.172-8.735 in 1:1 propensity matching analysis) as well as death. The MDCT (-) group seemed to also have a higher risk of recurrent stroke. Conclusion: Acute stroke patients who underwent MDCT experienced fewer deaths, cardiovascular events, and recurrent strokes during follow-up.

Original languageEnglish
Pages (from-to)114-122
Number of pages9
JournalYonsei medical journal
Volume58
Issue number1
DOIs
Publication statusPublished - 2017 Jan

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Coronary Artery Disease
Stroke
Tomography
Propensity Score
Proportional Hazards Models
Coronary Disease
Retrospective Studies
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kim, Young Dae ; Song, Dongbeom ; Nam, Hyo Suk ; Choi, Donghoon ; Kim, Jung Sun ; Kim, Byeong Keuk ; Chang, Hyuk Jae ; Choi, Hye Yeon ; Lee, Kijeong ; Yoo, Joonsang ; Lee, Hye Sun ; Nam, Chung Mo ; Heo, Ji Hoe. / Increased risk of cardiovascular events in stroke patients who had not undergone evaluation for coronary artery disease. In: Yonsei medical journal. 2017 ; Vol. 58, No. 1. pp. 114-122.
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title = "Increased risk of cardiovascular events in stroke patients who had not undergone evaluation for coronary artery disease",
abstract = "Purpose: Although asymptomatic coronary artery occlusive disease is common in stroke patients, the long-term advantages of undergoing evaluation for coronary arterial disease using multi-detector coronary computed tomography (MDCT) have not been well established in stroke patients. We compared long-term cardio-cerebrovascular outcomes between patients who underwent MDCT and those who did not. Materials and Methods: This was a retrospective study in a prospective cohort of consecutive ischemic stroke patients. Of the 3117 patients who were registered between July 2006 and December 2012, MDCT was performed in 1842 patients [MDCT (+) group] and not in 1275 patients [MDCT (-) group]. Occurrences of death, cardiovascular events, and recurrent stroke were compared between the groups using Cox proportional hazards models and propensity score analyses. Results: During the mean follow-up of 38.0±24.8 months, 486 (15.6{\%}) patients died, recurrent stroke occurred in 297 (9.5{\%}), and cardiovascular events occurred in 60 patients (1.9{\%}). Mean annual risks of death (9.34{\%} vs. 2.47{\%}), cardiovascular events (1.2{\%} vs. 0.29{\%}), and recurrent stroke (4.7{\%} vs. 2.56{\%}) were higher in the MDCT (-) group than in the MDCT (+) group. The Cox proportional hazards model and the five propensity score-adjusted models consistently demonstrated that the MDCT (-) group was at a high risk of cardiovascular events (hazard ratios 3.200, 95{\%} confidence interval 1.172-8.735 in 1:1 propensity matching analysis) as well as death. The MDCT (-) group seemed to also have a higher risk of recurrent stroke. Conclusion: Acute stroke patients who underwent MDCT experienced fewer deaths, cardiovascular events, and recurrent strokes during follow-up.",
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Increased risk of cardiovascular events in stroke patients who had not undergone evaluation for coronary artery disease. / Kim, Young Dae; Song, Dongbeom; Nam, Hyo Suk; Choi, Donghoon; Kim, Jung Sun; Kim, Byeong Keuk; Chang, Hyuk Jae; Choi, Hye Yeon; Lee, Kijeong; Yoo, Joonsang; Lee, Hye Sun; Nam, Chung Mo; Heo, Ji Hoe.

In: Yonsei medical journal, Vol. 58, No. 1, 01.2017, p. 114-122.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Increased risk of cardiovascular events in stroke patients who had not undergone evaluation for coronary artery disease

AU - Kim, Young Dae

AU - Song, Dongbeom

AU - Nam, Hyo Suk

AU - Choi, Donghoon

AU - Kim, Jung Sun

AU - Kim, Byeong Keuk

AU - Chang, Hyuk Jae

AU - Choi, Hye Yeon

AU - Lee, Kijeong

AU - Yoo, Joonsang

AU - Lee, Hye Sun

AU - Nam, Chung Mo

AU - Heo, Ji Hoe

PY - 2017/1

Y1 - 2017/1

N2 - Purpose: Although asymptomatic coronary artery occlusive disease is common in stroke patients, the long-term advantages of undergoing evaluation for coronary arterial disease using multi-detector coronary computed tomography (MDCT) have not been well established in stroke patients. We compared long-term cardio-cerebrovascular outcomes between patients who underwent MDCT and those who did not. Materials and Methods: This was a retrospective study in a prospective cohort of consecutive ischemic stroke patients. Of the 3117 patients who were registered between July 2006 and December 2012, MDCT was performed in 1842 patients [MDCT (+) group] and not in 1275 patients [MDCT (-) group]. Occurrences of death, cardiovascular events, and recurrent stroke were compared between the groups using Cox proportional hazards models and propensity score analyses. Results: During the mean follow-up of 38.0±24.8 months, 486 (15.6%) patients died, recurrent stroke occurred in 297 (9.5%), and cardiovascular events occurred in 60 patients (1.9%). Mean annual risks of death (9.34% vs. 2.47%), cardiovascular events (1.2% vs. 0.29%), and recurrent stroke (4.7% vs. 2.56%) were higher in the MDCT (-) group than in the MDCT (+) group. The Cox proportional hazards model and the five propensity score-adjusted models consistently demonstrated that the MDCT (-) group was at a high risk of cardiovascular events (hazard ratios 3.200, 95% confidence interval 1.172-8.735 in 1:1 propensity matching analysis) as well as death. The MDCT (-) group seemed to also have a higher risk of recurrent stroke. Conclusion: Acute stroke patients who underwent MDCT experienced fewer deaths, cardiovascular events, and recurrent strokes during follow-up.

AB - Purpose: Although asymptomatic coronary artery occlusive disease is common in stroke patients, the long-term advantages of undergoing evaluation for coronary arterial disease using multi-detector coronary computed tomography (MDCT) have not been well established in stroke patients. We compared long-term cardio-cerebrovascular outcomes between patients who underwent MDCT and those who did not. Materials and Methods: This was a retrospective study in a prospective cohort of consecutive ischemic stroke patients. Of the 3117 patients who were registered between July 2006 and December 2012, MDCT was performed in 1842 patients [MDCT (+) group] and not in 1275 patients [MDCT (-) group]. Occurrences of death, cardiovascular events, and recurrent stroke were compared between the groups using Cox proportional hazards models and propensity score analyses. Results: During the mean follow-up of 38.0±24.8 months, 486 (15.6%) patients died, recurrent stroke occurred in 297 (9.5%), and cardiovascular events occurred in 60 patients (1.9%). Mean annual risks of death (9.34% vs. 2.47%), cardiovascular events (1.2% vs. 0.29%), and recurrent stroke (4.7% vs. 2.56%) were higher in the MDCT (-) group than in the MDCT (+) group. The Cox proportional hazards model and the five propensity score-adjusted models consistently demonstrated that the MDCT (-) group was at a high risk of cardiovascular events (hazard ratios 3.200, 95% confidence interval 1.172-8.735 in 1:1 propensity matching analysis) as well as death. The MDCT (-) group seemed to also have a higher risk of recurrent stroke. Conclusion: Acute stroke patients who underwent MDCT experienced fewer deaths, cardiovascular events, and recurrent strokes during follow-up.

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