Increased risk of chronic spontaneous urticaria in patients with autoimmune thyroid diseases

A nationwide, population-based study

Yoon Seob Kim, Kyungdo Han, Ji Hyun Lee, Nack In Kim, Joo Young Roh, Seong Jun Seo, Hae Jun Song, Mingeol Lee, Jee Ho Choi, Young Min Park

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

There was no previous population-based study on the comparison of the risk of chronic spontaneous urticaria (CSU) between autoimmune thyroid diseases (AITD) and age- and gender-matched controls. The primary objective of this study was to evaluate the risk of CSU after diagnosis of AITD using national registry data from Korea. The secondary objective was to evaluate other risk factors of CSU. Based on the disease code diagnoses in 2003-2005, we composed an AITD group (n=3,659) and an age- and gender-matched control group (n=18,295). Each patient was tracked for whether CSU occurs or not until 2013. After adjusting for demographic differences and comorbidities, patients with AITD had a significantly higher rate of CSU compared to the control group (hazard ratio [HR], 1.46; 95% confidence interval [CI], 1.25-1.70; P<0.001). Among the AITD patients, the adjusted HR for CSU was higher in patients with Hashimoto's thyroiditis (HR, 1.50) than in those with Grave's disease (HR, 1.33), although the difference was not statistically significant (P=0.368). Analysis of CSU patients associated with AITD showed that female patients had a significantly higher risk of CSU compared to male ones (HR, 1.34; P=0.001) and that those with allergic rhinitis (HR, 1.51; P<0.001), atopic dermatitis (HR, 2.44; P<0.001), and asthma (HR, 1.50; P<0.001) had a significantly higher risk of CSU compared to patients without respective diseases. Our results demonstrated that AITD could be significantly associated with an increased risk of CSU.

Original languageEnglish
Pages (from-to)373-377
Number of pages5
JournalAllergy, Asthma and Immunology Research
Volume9
Issue number4
DOIs
Publication statusPublished - 2017 Jan 1

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Thyroid Diseases
Urticaria
Autoimmune Diseases
Population
Hashimoto Disease
Control Groups
Graves Disease
Atopic Dermatitis
Korea
Registries
Comorbidity
Research Design
Asthma
Demography
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

Cite this

Kim, Yoon Seob ; Han, Kyungdo ; Lee, Ji Hyun ; Kim, Nack In ; Roh, Joo Young ; Seo, Seong Jun ; Song, Hae Jun ; Lee, Mingeol ; Choi, Jee Ho ; Park, Young Min. / Increased risk of chronic spontaneous urticaria in patients with autoimmune thyroid diseases : A nationwide, population-based study. In: Allergy, Asthma and Immunology Research. 2017 ; Vol. 9, No. 4. pp. 373-377.
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Increased risk of chronic spontaneous urticaria in patients with autoimmune thyroid diseases : A nationwide, population-based study. / Kim, Yoon Seob; Han, Kyungdo; Lee, Ji Hyun; Kim, Nack In; Roh, Joo Young; Seo, Seong Jun; Song, Hae Jun; Lee, Mingeol; Choi, Jee Ho; Park, Young Min.

In: Allergy, Asthma and Immunology Research, Vol. 9, No. 4, 01.01.2017, p. 373-377.

Research output: Contribution to journalArticle

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