Increased serum angiopoietin-like 6 ahead of metabolic syndrome in a prospective cohort study

Jun Namkung, Joon Hyung Sohn, Jae Seung Chang, Sang Wook Park, Jang Young Kim, Sang Baek Koh, In Deok Kong, Kyu Sang Park

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Background: Despite being an anti-obesity hepatokine, the levels of serum angiopoietin-like 6 (ANGPTL6) are elevated in various metabolic diseases. Thus, ANGPTL6 expression may reflect metabolic burden and may have compensatory roles. This study investigated the association between serum ANGPTL6 levels and new-onset metabolic syndrome. Methods: In total, 221 participants without metabolic syndrome were randomly selected from a rural cohort in Korea. Baseline serum ANGPTL6 levels were measured using an enzyme-linked immunosorbent assay. Anthropometric and biochemical markers were analyzed before and after follow-up examinations. Results: During an average follow-up period of 2.75 (interquartile range, 0.76) years, 82 participants (37.1%) presented new-onset metabolic syndrome and had higher ANGPTL6 levels before onset than those without metabolic syndrome (48.03±18.84 ng/mL vs. 64.75±43.35 ng/mL, P=0.001). In the multivariable adjusted models, the odds ratio for the development of metabolic syndrome in the highest quartile of ANGPTL6 levels was 3.61 (95% confidence interval, 1.27 to 10.26). The use of ANGPTL6 levels in addition to the conventional components improved the prediction of new-onset metabolic syndrome (area under the receiver operating characteristic curve: 0.775 vs. 0.807, P=0.036). Conclusion: Increased serum ANGPTL6 levels precede the development of metabolic syndrome and its components, including low high density lipoprotein, high triglyceride, and high glucose levels, which have an independent predictive value for metabolic syndrome.

Original languageEnglish
Pages (from-to)521-529
Number of pages9
JournalDiabetes and Metabolism Journal
Issue number4
Publication statusPublished - 2019 Aug 1

Bibliographical note

Funding Information:
This research was supported by grants from the Korea Centers for Disease Control and Prevention (2010-E71003-00 to SBK) and from the National Research Foundation of Korea funded by the Ministry of Science, ICT & Future Planning (NRF-2017R1A5A2015369 to KSP).

Publisher Copyright:
Copyright © 2019 Korean Diabetes Association.

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism


Dive into the research topics of 'Increased serum angiopoietin-like 6 ahead of metabolic syndrome in a prospective cohort study'. Together they form a unique fingerprint.

Cite this