Increased size-sorting performance in gravitational SPLITT by using a pinched sample inlet design

Myeong Hee Moon, Dukjin Kang, So Yeon Kwon, Seungho Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Split-flow thin fractionation is a continuous, flow-assisted separation technique for sorting macromolecules and particulate matter on a preparative scale. On reducing the thickness of the sample inlet conduit of a gravitational split-flow thin fractionation channel, size-sorting performance is found to increase since particles that are continuously fed into the channel can be more rapidly compressed toward the upper wall of the channel. Experiments are carried out by measuring the number percentage of particles eluted at each outlet as a function of different thickness values of the sample inlet conduit. The effects that the total thickness of the gravitational split-flow thin fractionation channel and the sample feed concentration have on the size-fractionation performance are examined with the goal of determining the best pinched sample inlet, gravitational split-flow thin fractionation channel design.

Original languageEnglish
Pages (from-to)1675-1682
Number of pages8
JournalJournal of Separation Science
Volume26
Issue number18
DOIs
Publication statusPublished - 2003 Dec 1

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Filtration and Separation

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