Increasing incidence of listeriosis and infection-Associated clinical outcomes

Min Hyuk Choi, Yu Jin Park, Myungsook Kim, Young Hee Seo, Young Ah Kim, Jun Yong Choi, Dongeun Yong, Seok Hoon Jeong, Kyungwon Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Listeriosis caused by Listeria monocytogenes has a high case-fatality rate (CFR) of approximately 20% to 30%. An increasing incidence of listeriosis has been reported in many countries recently. We investigated the annual incidence, clinical characteristics, and outcomes of listeriosis at three different hospitals in Korea and evaluated the effects of appropriate empiric antimicrobial treatments on patient outcomes. Methods: We retrospectively collected the data of all culture-positive cases of human listeriosis from three hospitals of different sizes in Korea during 2006-2016 and calculated the annual number of cases and incidence per 100,000 admissions. Results: A total of 58 patients with L. monocytogenes were included in this study. The incidence of listeriosis was significantly higher in 2013-2016 than in 2006-2012 (RR 3.1; 95% CI 1.79-5.36; P<0.001), mainly because of an increase in patients over 60 years of age (RR 3.69; 95% CI 1.70-8.02; P<0.001). Multivariate analysis showed that healthcare-Associated infection (adjusted OR, 12.15; 95% CI, 2.56-86.01; P=0.004) and empirical treatment with first-line antimicrobial agents (adjusted OR, 0.08; 95% CI, 0.00-0.63; P=0.044) were associated with CFR. Conclusions: Healthcare-Associated infections caused by L. monocytogenes are associated with high CFR. Adequate initial empirical treatments could reduce CFR, suggesting that careful consideration of an empirical antimicrobial regimen is warranted for elderly or immunocompromised patients admitted to the hospital.

Original languageEnglish
Pages (from-to)102-109
Number of pages8
JournalAnnals of laboratory medicine
Volume38
Issue number2
DOIs
Publication statusPublished - 2018 Jan 1

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Listeriosis
Listeria monocytogenes
Incidence
Infection
Mortality
Listeria
Korea
Cross Infection
Anti-Infective Agents
Health Facility Size
Immunocompromised Host
Therapeutics
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Choi, Min Hyuk ; Park, Yu Jin ; Kim, Myungsook ; Seo, Young Hee ; Kim, Young Ah ; Choi, Jun Yong ; Yong, Dongeun ; Jeong, Seok Hoon ; Lee, Kyungwon. / Increasing incidence of listeriosis and infection-Associated clinical outcomes. In: Annals of laboratory medicine. 2018 ; Vol. 38, No. 2. pp. 102-109.
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abstract = "Background: Listeriosis caused by Listeria monocytogenes has a high case-fatality rate (CFR) of approximately 20{\%} to 30{\%}. An increasing incidence of listeriosis has been reported in many countries recently. We investigated the annual incidence, clinical characteristics, and outcomes of listeriosis at three different hospitals in Korea and evaluated the effects of appropriate empiric antimicrobial treatments on patient outcomes. Methods: We retrospectively collected the data of all culture-positive cases of human listeriosis from three hospitals of different sizes in Korea during 2006-2016 and calculated the annual number of cases and incidence per 100,000 admissions. Results: A total of 58 patients with L. monocytogenes were included in this study. The incidence of listeriosis was significantly higher in 2013-2016 than in 2006-2012 (RR 3.1; 95{\%} CI 1.79-5.36; P<0.001), mainly because of an increase in patients over 60 years of age (RR 3.69; 95{\%} CI 1.70-8.02; P<0.001). Multivariate analysis showed that healthcare-Associated infection (adjusted OR, 12.15; 95{\%} CI, 2.56-86.01; P=0.004) and empirical treatment with first-line antimicrobial agents (adjusted OR, 0.08; 95{\%} CI, 0.00-0.63; P=0.044) were associated with CFR. Conclusions: Healthcare-Associated infections caused by L. monocytogenes are associated with high CFR. Adequate initial empirical treatments could reduce CFR, suggesting that careful consideration of an empirical antimicrobial regimen is warranted for elderly or immunocompromised patients admitted to the hospital.",
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Increasing incidence of listeriosis and infection-Associated clinical outcomes. / Choi, Min Hyuk; Park, Yu Jin; Kim, Myungsook; Seo, Young Hee; Kim, Young Ah; Choi, Jun Yong; Yong, Dongeun; Jeong, Seok Hoon; Lee, Kyungwon.

In: Annals of laboratory medicine, Vol. 38, No. 2, 01.01.2018, p. 102-109.

Research output: Contribution to journalArticle

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T1 - Increasing incidence of listeriosis and infection-Associated clinical outcomes

AU - Choi, Min Hyuk

AU - Park, Yu Jin

AU - Kim, Myungsook

AU - Seo, Young Hee

AU - Kim, Young Ah

AU - Choi, Jun Yong

AU - Yong, Dongeun

AU - Jeong, Seok Hoon

AU - Lee, Kyungwon

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N2 - Background: Listeriosis caused by Listeria monocytogenes has a high case-fatality rate (CFR) of approximately 20% to 30%. An increasing incidence of listeriosis has been reported in many countries recently. We investigated the annual incidence, clinical characteristics, and outcomes of listeriosis at three different hospitals in Korea and evaluated the effects of appropriate empiric antimicrobial treatments on patient outcomes. Methods: We retrospectively collected the data of all culture-positive cases of human listeriosis from three hospitals of different sizes in Korea during 2006-2016 and calculated the annual number of cases and incidence per 100,000 admissions. Results: A total of 58 patients with L. monocytogenes were included in this study. The incidence of listeriosis was significantly higher in 2013-2016 than in 2006-2012 (RR 3.1; 95% CI 1.79-5.36; P<0.001), mainly because of an increase in patients over 60 years of age (RR 3.69; 95% CI 1.70-8.02; P<0.001). Multivariate analysis showed that healthcare-Associated infection (adjusted OR, 12.15; 95% CI, 2.56-86.01; P=0.004) and empirical treatment with first-line antimicrobial agents (adjusted OR, 0.08; 95% CI, 0.00-0.63; P=0.044) were associated with CFR. Conclusions: Healthcare-Associated infections caused by L. monocytogenes are associated with high CFR. Adequate initial empirical treatments could reduce CFR, suggesting that careful consideration of an empirical antimicrobial regimen is warranted for elderly or immunocompromised patients admitted to the hospital.

AB - Background: Listeriosis caused by Listeria monocytogenes has a high case-fatality rate (CFR) of approximately 20% to 30%. An increasing incidence of listeriosis has been reported in many countries recently. We investigated the annual incidence, clinical characteristics, and outcomes of listeriosis at three different hospitals in Korea and evaluated the effects of appropriate empiric antimicrobial treatments on patient outcomes. Methods: We retrospectively collected the data of all culture-positive cases of human listeriosis from three hospitals of different sizes in Korea during 2006-2016 and calculated the annual number of cases and incidence per 100,000 admissions. Results: A total of 58 patients with L. monocytogenes were included in this study. The incidence of listeriosis was significantly higher in 2013-2016 than in 2006-2012 (RR 3.1; 95% CI 1.79-5.36; P<0.001), mainly because of an increase in patients over 60 years of age (RR 3.69; 95% CI 1.70-8.02; P<0.001). Multivariate analysis showed that healthcare-Associated infection (adjusted OR, 12.15; 95% CI, 2.56-86.01; P=0.004) and empirical treatment with first-line antimicrobial agents (adjusted OR, 0.08; 95% CI, 0.00-0.63; P=0.044) were associated with CFR. Conclusions: Healthcare-Associated infections caused by L. monocytogenes are associated with high CFR. Adequate initial empirical treatments could reduce CFR, suggesting that careful consideration of an empirical antimicrobial regimen is warranted for elderly or immunocompromised patients admitted to the hospital.

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