Carbapenem-resistant Acinetobacter spp. have been increasingly reported worldwide with the production of OXA-type carbapenemases as the main mechanism of carbapenem resistance. The prevalent blaOXA genes are known to vary significantly depending on time and place of isolation. We investigated the prevalence of blaOXA genes by PCR in Acinetobacter spp. isolated in Korea. Among a total of 336 isolates collected from Hospital A from 2002 to 2011, the overall proportion of blaOXA-23-like, ISAba1-associated blaOXA-51-like, and blaOXA-182 genes were 44.0%, 49.7%, and 5.1%, respectively. The blaOXA-58-like gene was detected in only 1 isolate. A drastic increase in Acinetobacter isolates with blaOXA-23-like genes and a decrease in isolates harboring ISAba1-associated blaOXA-51-like genes have been observed since the mid-2000s. The blaOXA-23-like genes were detected in all carbapenem-nonsusceptible isolates collected in 2011 from 9 hospitals. The OXA-182, which belongs to the fifth group of OXA-type carbapenemase, was detected in Acinetobacter baumannii isolates recovered as early as 2002. It is worrisome results that blaOXA-182-carrying Acinetobacter nosocomialis has emerged and caused outbreaks of infection.
|Number of pages||4|
|Journal||Diagnostic Microbiology and Infectious Disease|
|Publication status||Published - 2013 Oct 1|
All Science Journal Classification (ASJC) codes
- Microbiology (medical)
- Infectious Diseases