Abstract
Carbapenem-resistant Acinetobacter spp. have been increasingly reported worldwide with the production of OXA-type carbapenemases as the main mechanism of carbapenem resistance. The prevalent blaOXA genes are known to vary significantly depending on time and place of isolation. We investigated the prevalence of blaOXA genes by PCR in Acinetobacter spp. isolated in Korea. Among a total of 336 isolates collected from Hospital A from 2002 to 2011, the overall proportion of blaOXA-23-like, ISAba1-associated blaOXA-51-like, and blaOXA-182 genes were 44.0%, 49.7%, and 5.1%, respectively. The blaOXA-58-like gene was detected in only 1 isolate. A drastic increase in Acinetobacter isolates with blaOXA-23-like genes and a decrease in isolates harboring ISAba1-associated blaOXA-51-like genes have been observed since the mid-2000s. The blaOXA-23-like genes were detected in all carbapenem-nonsusceptible isolates collected in 2011 from 9 hospitals. The OXA-182, which belongs to the fifth group of OXA-type carbapenemase, was detected in Acinetobacter baumannii isolates recovered as early as 2002. It is worrisome results that blaOXA-182-carrying Acinetobacter nosocomialis has emerged and caused outbreaks of infection.
| Original language | English |
|---|---|
| Pages (from-to) | 160-163 |
| Number of pages | 4 |
| Journal | Diagnostic Microbiology and Infectious Disease |
| Volume | 77 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2013 Oct 1 |
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All Science Journal Classification (ASJC) codes
- Microbiology (medical)
- Infectious Diseases
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Increasing prevalence of blaOXA-23-carrying Acinetobacter baumannii and the emergence of blaOXA-182-carrying Acinetobacter nosocomialis in Korea. / Lee, Yangsoon; Kim, Young Ree; Kim, Jayoung; Park, Yeon Joon; Song, Wonkeun; Shin, Jong Hee; Uh, Young; Lee, Kyutaeg; Lee, Seong Hee; Cho, Ji Hyun; Yong, Dongeun; Jeong, Seok Hoon; Lee, Kyungwon; Chong, Yunsop.
In: Diagnostic Microbiology and Infectious Disease, Vol. 77, No. 2, 01.10.2013, p. 160-163.Research output: Contribution to journal › Article
TY - JOUR
T1 - Increasing prevalence of blaOXA-23-carrying Acinetobacter baumannii and the emergence of blaOXA-182-carrying Acinetobacter nosocomialis in Korea
AU - Lee, Yangsoon
AU - Kim, Young Ree
AU - Kim, Jayoung
AU - Park, Yeon Joon
AU - Song, Wonkeun
AU - Shin, Jong Hee
AU - Uh, Young
AU - Lee, Kyutaeg
AU - Lee, Seong Hee
AU - Cho, Ji Hyun
AU - Yong, Dongeun
AU - Jeong, Seok Hoon
AU - Lee, Kyungwon
AU - Chong, Yunsop
PY - 2013/10/1
Y1 - 2013/10/1
N2 - Carbapenem-resistant Acinetobacter spp. have been increasingly reported worldwide with the production of OXA-type carbapenemases as the main mechanism of carbapenem resistance. The prevalent blaOXA genes are known to vary significantly depending on time and place of isolation. We investigated the prevalence of blaOXA genes by PCR in Acinetobacter spp. isolated in Korea. Among a total of 336 isolates collected from Hospital A from 2002 to 2011, the overall proportion of blaOXA-23-like, ISAba1-associated blaOXA-51-like, and blaOXA-182 genes were 44.0%, 49.7%, and 5.1%, respectively. The blaOXA-58-like gene was detected in only 1 isolate. A drastic increase in Acinetobacter isolates with blaOXA-23-like genes and a decrease in isolates harboring ISAba1-associated blaOXA-51-like genes have been observed since the mid-2000s. The blaOXA-23-like genes were detected in all carbapenem-nonsusceptible isolates collected in 2011 from 9 hospitals. The OXA-182, which belongs to the fifth group of OXA-type carbapenemase, was detected in Acinetobacter baumannii isolates recovered as early as 2002. It is worrisome results that blaOXA-182-carrying Acinetobacter nosocomialis has emerged and caused outbreaks of infection.
AB - Carbapenem-resistant Acinetobacter spp. have been increasingly reported worldwide with the production of OXA-type carbapenemases as the main mechanism of carbapenem resistance. The prevalent blaOXA genes are known to vary significantly depending on time and place of isolation. We investigated the prevalence of blaOXA genes by PCR in Acinetobacter spp. isolated in Korea. Among a total of 336 isolates collected from Hospital A from 2002 to 2011, the overall proportion of blaOXA-23-like, ISAba1-associated blaOXA-51-like, and blaOXA-182 genes were 44.0%, 49.7%, and 5.1%, respectively. The blaOXA-58-like gene was detected in only 1 isolate. A drastic increase in Acinetobacter isolates with blaOXA-23-like genes and a decrease in isolates harboring ISAba1-associated blaOXA-51-like genes have been observed since the mid-2000s. The blaOXA-23-like genes were detected in all carbapenem-nonsusceptible isolates collected in 2011 from 9 hospitals. The OXA-182, which belongs to the fifth group of OXA-type carbapenemase, was detected in Acinetobacter baumannii isolates recovered as early as 2002. It is worrisome results that blaOXA-182-carrying Acinetobacter nosocomialis has emerged and caused outbreaks of infection.
UR - http://www.scopus.com/inward/record.url?scp=84884411650&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884411650&partnerID=8YFLogxK
U2 - 10.1016/j.diagmicrobio.2013.06.009
DO - 10.1016/j.diagmicrobio.2013.06.009
M3 - Article
C2 - 23891219
AN - SCOPUS:84884411650
VL - 77
SP - 160
EP - 163
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
SN - 0732-8893
IS - 2
ER -