Increasing prevalence of blaOXA-23-carrying Acinetobacter baumannii and the emergence of blaOXA-182-carrying Acinetobacter nosocomialis in Korea

Yangsoon Lee, Young Ree Kim, Jayoung Kim, Yeon Joon Park, Wonkeun Song, Jong Hee Shin, Young Uh, Kyutaeg Lee, Seong Hee Lee, Ji Hyun Cho, Dongeun Yong, Seok Hoon Jeong, Kyungwon Lee, Yunsop Chong

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10 Citations (Scopus)

Abstract

Carbapenem-resistant Acinetobacter spp. have been increasingly reported worldwide with the production of OXA-type carbapenemases as the main mechanism of carbapenem resistance. The prevalent blaOXA genes are known to vary significantly depending on time and place of isolation. We investigated the prevalence of blaOXA genes by PCR in Acinetobacter spp. isolated in Korea. Among a total of 336 isolates collected from Hospital A from 2002 to 2011, the overall proportion of blaOXA-23-like, ISAba1-associated blaOXA-51-like, and blaOXA-182 genes were 44.0%, 49.7%, and 5.1%, respectively. The blaOXA-58-like gene was detected in only 1 isolate. A drastic increase in Acinetobacter isolates with blaOXA-23-like genes and a decrease in isolates harboring ISAba1-associated blaOXA-51-like genes have been observed since the mid-2000s. The blaOXA-23-like genes were detected in all carbapenem-nonsusceptible isolates collected in 2011 from 9 hospitals. The OXA-182, which belongs to the fifth group of OXA-type carbapenemase, was detected in Acinetobacter baumannii isolates recovered as early as 2002. It is worrisome results that blaOXA-182-carrying Acinetobacter nosocomialis has emerged and caused outbreaks of infection.

Original languageEnglish
Pages (from-to)160-163
Number of pages4
JournalDiagnostic Microbiology and Infectious Disease
Volume77
Issue number2
DOIs
Publication statusPublished - 2013 Oct 1

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Acinetobacter
Korea
Carbapenems
Genes
Acinetobacter baumannii
Acinetobacter baumannii beta-lactamase OXA-23
Disease Outbreaks
Polymerase Chain Reaction
Infection
Asp(5)-oxytocin

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Lee, Yangsoon ; Kim, Young Ree ; Kim, Jayoung ; Park, Yeon Joon ; Song, Wonkeun ; Shin, Jong Hee ; Uh, Young ; Lee, Kyutaeg ; Lee, Seong Hee ; Cho, Ji Hyun ; Yong, Dongeun ; Jeong, Seok Hoon ; Lee, Kyungwon ; Chong, Yunsop. / Increasing prevalence of blaOXA-23-carrying Acinetobacter baumannii and the emergence of blaOXA-182-carrying Acinetobacter nosocomialis in Korea. In: Diagnostic Microbiology and Infectious Disease. 2013 ; Vol. 77, No. 2. pp. 160-163.
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abstract = "Carbapenem-resistant Acinetobacter spp. have been increasingly reported worldwide with the production of OXA-type carbapenemases as the main mechanism of carbapenem resistance. The prevalent blaOXA genes are known to vary significantly depending on time and place of isolation. We investigated the prevalence of blaOXA genes by PCR in Acinetobacter spp. isolated in Korea. Among a total of 336 isolates collected from Hospital A from 2002 to 2011, the overall proportion of blaOXA-23-like, ISAba1-associated blaOXA-51-like, and blaOXA-182 genes were 44.0{\%}, 49.7{\%}, and 5.1{\%}, respectively. The blaOXA-58-like gene was detected in only 1 isolate. A drastic increase in Acinetobacter isolates with blaOXA-23-like genes and a decrease in isolates harboring ISAba1-associated blaOXA-51-like genes have been observed since the mid-2000s. The blaOXA-23-like genes were detected in all carbapenem-nonsusceptible isolates collected in 2011 from 9 hospitals. The OXA-182, which belongs to the fifth group of OXA-type carbapenemase, was detected in Acinetobacter baumannii isolates recovered as early as 2002. It is worrisome results that blaOXA-182-carrying Acinetobacter nosocomialis has emerged and caused outbreaks of infection.",
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Increasing prevalence of blaOXA-23-carrying Acinetobacter baumannii and the emergence of blaOXA-182-carrying Acinetobacter nosocomialis in Korea. / Lee, Yangsoon; Kim, Young Ree; Kim, Jayoung; Park, Yeon Joon; Song, Wonkeun; Shin, Jong Hee; Uh, Young; Lee, Kyutaeg; Lee, Seong Hee; Cho, Ji Hyun; Yong, Dongeun; Jeong, Seok Hoon; Lee, Kyungwon; Chong, Yunsop.

In: Diagnostic Microbiology and Infectious Disease, Vol. 77, No. 2, 01.10.2013, p. 160-163.

Research output: Contribution to journalArticle

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AU - Lee, Yangsoon

AU - Kim, Young Ree

AU - Kim, Jayoung

AU - Park, Yeon Joon

AU - Song, Wonkeun

AU - Shin, Jong Hee

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AU - Lee, Kyungwon

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