Increasing prevalence of toxin A-negative, toxin B-positive isolates of Clostridium difficile in Korea: Impact on laboratory diagnosis

Heejung Kim; Thomas V. Riley; Myungsook Kim; Ki Kim Chang; Dongeun Yong; Kyungwon Lee; Yunsop Chong; Jong Woo Park

doi:10.1128/JCM.01188-07

Increasing prevalence of toxin A-negative, toxin B-positive isolates of Clostridium difficile in Korea: Impact on laboratory diagnosis

Heejung Kim, Thomas V. Riley, Myungsook Kim, Ki Kim Chang, Dongeun Yong, Kyungwon Lee, Yunsop Chong, Jong Woo Park

Department of Laboratory Medicine

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

Of 462 Korean Clostridium difficile isolates, 77.5% were toxin B positive but 21.4% were toxin A negative (A^- B⁺). The binary toxin gene was detected in nine isolates. A higher fluoroquinolone resistance of A^- B⁺ strains may contribute to the increase of these strains. Toxin A detection alone may underdiagnose C. difficile-associated disease.

Original language	English
Pages (from-to)	1116-1117
Number of pages	2
Journal	Journal of Clinical Microbiology
Volume	46
Issue number	3
DOIs	https://doi.org/10.1128/JCM.01188-07
Publication status	Published - 2008 Mar

All Science Journal Classification (ASJC) codes

Microbiology (medical)

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10.1128/JCM.01188-07

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title = "Increasing prevalence of toxin A-negative, toxin B-positive isolates of Clostridium difficile in Korea: Impact on laboratory diagnosis",

abstract = "Of 462 Korean Clostridium difficile isolates, 77.5% were toxin B positive but 21.4% were toxin A negative (A- B+). The binary toxin gene was detected in nine isolates. A higher fluoroquinolone resistance of A- B+ strains may contribute to the increase of these strains. Toxin A detection alone may underdiagnose C. difficile-associated disease.",

author = "Heejung Kim and Riley, {Thomas V.} and Myungsook Kim and Chang, {Ki Kim} and Dongeun Yong and Kyungwon Lee and Yunsop Chong and Park, {Jong Woo}",

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AU - Kim, Heejung

AU - Riley, Thomas V.

AU - Kim, Myungsook

AU - Chang, Ki Kim

AU - Yong, Dongeun

AU - Lee, Kyungwon

AU - Chong, Yunsop

AU - Park, Jong Woo

PY - 2008/3

Y1 - 2008/3

N2 - Of 462 Korean Clostridium difficile isolates, 77.5% were toxin B positive but 21.4% were toxin A negative (A- B+). The binary toxin gene was detected in nine isolates. A higher fluoroquinolone resistance of A- B+ strains may contribute to the increase of these strains. Toxin A detection alone may underdiagnose C. difficile-associated disease.

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Increasing prevalence of toxin A-negative, toxin B-positive isolates of Clostridium difficile in Korea: Impact on laboratory diagnosis

Abstract

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