Increment of growth factors in mouse skin treated with non-thermal plasma

Byul Bo Ra Choi, Jeong Hae Choi, Jeong Ji, Ki Won Song, Hae June Lee, Gyoo Cheon Kim

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Non-thermal plasma (NTP) has several beneficial effects, and can be applied as a novel instrument for skin treatment. Recently, many types of NTP have been developed for potential medical or clinical applications, but their direct effects on skin activation remain unclear. In this study, the effect of NTP on the alteration of mouse skin tissue was analyzed. After NTP treatment, there were no signs of tissue damage in mouse skin, whereas significant increases in epidermal thickness and dermal collagen density were detected. Furthermore, treatment with NTP increased the expression of various growth factors, including TGF-α, TGF-β, VEGF, GM-CSF, and EGF, in skin tissue. Therefore, NTP treatment on skin induces the expression of growth factors without causing damage, a phenomenon that might be directly linked to epidermal expansion and dermal tissue remodeling.

Original languageEnglish
Pages (from-to)1203-1209
Number of pages7
JournalInternational Journal of Medical Sciences
Volume15
Issue number11
DOIs
Publication statusPublished - 2018 Jul 30

Bibliographical note

Funding Information:
This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) & funded by the Korean government (2016M3A9C6918283).

Funding Information:
This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) & funded by the Korean government (2016M3A9C6918283)

Publisher Copyright:
© Ivyspring International Publisher.

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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