Increments of α-dystroglycan expression in liver metastasis correlate with poor survival in gastric cancer

Wha Moon Yong, SunYoung Rha, Zhang Xianglan, Hei Cheul Jeung, Ick Yang Woo, Obin Kwon, Heon Jeong Jae, Hah Cheon Sung, Choon Yoo Nae, Hyuncheol Chung

Research output: Contribution to journalArticle

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Abstract

Background: Dystroglycan (DG) is a recently focused adhesion molecule with possible roles in cancer development and progression. We investigated correlations between α-DG expression and prognosis in gastric carcinoma with liver metastasis. Methods: For 40 patients with gastric adenocarcinoma and liver-only metastasis, α-DG expression was determined by immunohistochemistry in paraffin-embedded surgical specimens of resected stomach tumor, resected liver metastasis, and their normal counterpart tissues. Correlations between α-DG expression and prognosis were retrospectively analyzed. Results: α-DG expression was higher in primary gastric cancer (P = 0.006) and lower in liver metastasis (P = 0.002) than in each normal counterpart. In primary stomach cancer, patients who had lower α-DG expression in tumors than in normal counterparts showed poor overall survival (OS) (P = 0.028). In contrast, in the liver, patients who had higher α-DG expression in tumors than in normal counterparts showed poor OS (P = 0.022). Also, higher α-DG expression in liver metastasis than in stomach tumors led to poor recurrence-free survival (P = 0.023) and OS (P = 0.056). Conclusions: This approach may be used to further understanding of the pathogenesis of liver metastasis from gastric cancer. Further studies are warranted to reveal the mechanisms of α-DG dysregulation in liver metastasis.

Original languageEnglish
Pages (from-to)459-465
Number of pages7
JournalJournal of Surgical Oncology
Volume100
Issue number6
DOIs
Publication statusPublished - 2009 Nov 1

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Dystroglycans
Stomach Neoplasms
Neoplasm Metastasis
Survival
Liver
Stomach
Neoplasms
Paraffin
Adenocarcinoma
Immunohistochemistry
Carcinoma

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Yong, Wha Moon ; Rha, SunYoung ; Xianglan, Zhang ; Jeung, Hei Cheul ; Woo, Ick Yang ; Kwon, Obin ; Jae, Heon Jeong ; Sung, Hah Cheon ; Nae, Choon Yoo ; Chung, Hyuncheol. / Increments of α-dystroglycan expression in liver metastasis correlate with poor survival in gastric cancer. In: Journal of Surgical Oncology. 2009 ; Vol. 100, No. 6. pp. 459-465.
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abstract = "Background: Dystroglycan (DG) is a recently focused adhesion molecule with possible roles in cancer development and progression. We investigated correlations between α-DG expression and prognosis in gastric carcinoma with liver metastasis. Methods: For 40 patients with gastric adenocarcinoma and liver-only metastasis, α-DG expression was determined by immunohistochemistry in paraffin-embedded surgical specimens of resected stomach tumor, resected liver metastasis, and their normal counterpart tissues. Correlations between α-DG expression and prognosis were retrospectively analyzed. Results: α-DG expression was higher in primary gastric cancer (P = 0.006) and lower in liver metastasis (P = 0.002) than in each normal counterpart. In primary stomach cancer, patients who had lower α-DG expression in tumors than in normal counterparts showed poor overall survival (OS) (P = 0.028). In contrast, in the liver, patients who had higher α-DG expression in tumors than in normal counterparts showed poor OS (P = 0.022). Also, higher α-DG expression in liver metastasis than in stomach tumors led to poor recurrence-free survival (P = 0.023) and OS (P = 0.056). Conclusions: This approach may be used to further understanding of the pathogenesis of liver metastasis from gastric cancer. Further studies are warranted to reveal the mechanisms of α-DG dysregulation in liver metastasis.",
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Increments of α-dystroglycan expression in liver metastasis correlate with poor survival in gastric cancer. / Yong, Wha Moon; Rha, SunYoung; Xianglan, Zhang; Jeung, Hei Cheul; Woo, Ick Yang; Kwon, Obin; Jae, Heon Jeong; Sung, Hah Cheon; Nae, Choon Yoo; Chung, Hyuncheol.

In: Journal of Surgical Oncology, Vol. 100, No. 6, 01.11.2009, p. 459-465.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Increments of α-dystroglycan expression in liver metastasis correlate with poor survival in gastric cancer

AU - Yong, Wha Moon

AU - Rha, SunYoung

AU - Xianglan, Zhang

AU - Jeung, Hei Cheul

AU - Woo, Ick Yang

AU - Kwon, Obin

AU - Jae, Heon Jeong

AU - Sung, Hah Cheon

AU - Nae, Choon Yoo

AU - Chung, Hyuncheol

PY - 2009/11/1

Y1 - 2009/11/1

N2 - Background: Dystroglycan (DG) is a recently focused adhesion molecule with possible roles in cancer development and progression. We investigated correlations between α-DG expression and prognosis in gastric carcinoma with liver metastasis. Methods: For 40 patients with gastric adenocarcinoma and liver-only metastasis, α-DG expression was determined by immunohistochemistry in paraffin-embedded surgical specimens of resected stomach tumor, resected liver metastasis, and their normal counterpart tissues. Correlations between α-DG expression and prognosis were retrospectively analyzed. Results: α-DG expression was higher in primary gastric cancer (P = 0.006) and lower in liver metastasis (P = 0.002) than in each normal counterpart. In primary stomach cancer, patients who had lower α-DG expression in tumors than in normal counterparts showed poor overall survival (OS) (P = 0.028). In contrast, in the liver, patients who had higher α-DG expression in tumors than in normal counterparts showed poor OS (P = 0.022). Also, higher α-DG expression in liver metastasis than in stomach tumors led to poor recurrence-free survival (P = 0.023) and OS (P = 0.056). Conclusions: This approach may be used to further understanding of the pathogenesis of liver metastasis from gastric cancer. Further studies are warranted to reveal the mechanisms of α-DG dysregulation in liver metastasis.

AB - Background: Dystroglycan (DG) is a recently focused adhesion molecule with possible roles in cancer development and progression. We investigated correlations between α-DG expression and prognosis in gastric carcinoma with liver metastasis. Methods: For 40 patients with gastric adenocarcinoma and liver-only metastasis, α-DG expression was determined by immunohistochemistry in paraffin-embedded surgical specimens of resected stomach tumor, resected liver metastasis, and their normal counterpart tissues. Correlations between α-DG expression and prognosis were retrospectively analyzed. Results: α-DG expression was higher in primary gastric cancer (P = 0.006) and lower in liver metastasis (P = 0.002) than in each normal counterpart. In primary stomach cancer, patients who had lower α-DG expression in tumors than in normal counterparts showed poor overall survival (OS) (P = 0.028). In contrast, in the liver, patients who had higher α-DG expression in tumors than in normal counterparts showed poor OS (P = 0.022). Also, higher α-DG expression in liver metastasis than in stomach tumors led to poor recurrence-free survival (P = 0.023) and OS (P = 0.056). Conclusions: This approach may be used to further understanding of the pathogenesis of liver metastasis from gastric cancer. Further studies are warranted to reveal the mechanisms of α-DG dysregulation in liver metastasis.

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