Increments of α-dystroglycan expression in liver metastasis correlate with poor survival in gastric cancer

Wha Moon Yong, Young Rha Sun, Zhang Xianglan, Hei Cheul Jeung, Ick Yang Woo, Obin Kwon, Heon Jeong Jae, Hah Cheon Sung, Choon Yoo Nae, Cheol Chung Hyun

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8 Citations (Scopus)

Abstract

Background: Dystroglycan (DG) is a recently focused adhesion molecule with possible roles in cancer development and progression. We investigated correlations between α-DG expression and prognosis in gastric carcinoma with liver metastasis. Methods: For 40 patients with gastric adenocarcinoma and liver-only metastasis, α-DG expression was determined by immunohistochemistry in paraffin-embedded surgical specimens of resected stomach tumor, resected liver metastasis, and their normal counterpart tissues. Correlations between α-DG expression and prognosis were retrospectively analyzed. Results: α-DG expression was higher in primary gastric cancer (P = 0.006) and lower in liver metastasis (P = 0.002) than in each normal counterpart. In primary stomach cancer, patients who had lower α-DG expression in tumors than in normal counterparts showed poor overall survival (OS) (P = 0.028). In contrast, in the liver, patients who had higher α-DG expression in tumors than in normal counterparts showed poor OS (P = 0.022). Also, higher α-DG expression in liver metastasis than in stomach tumors led to poor recurrence-free survival (P = 0.023) and OS (P = 0.056). Conclusions: This approach may be used to further understanding of the pathogenesis of liver metastasis from gastric cancer. Further studies are warranted to reveal the mechanisms of α-DG dysregulation in liver metastasis.

Original languageEnglish
Pages (from-to)459-465
Number of pages7
JournalJournal of surgical oncology
Volume100
Issue number6
DOIs
Publication statusPublished - 2009 Nov 1

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All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

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