Independent association of TG/HDL-C with urinary albumin excretion in normotensive subjects in a rural Korean population

Hee Taik Kang, Jong Koo Kim, Jang Young Kim, John A. Linton, JinHa Yoon, Sangbaek Koh

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Abstract

Background: The ratio of triglycerides (TG, mg/dl) to high-density lipoprotein cholesterol (HDL-C, mg/dl) is a reliable indicator of insulin resistance and atherosclerotic diseases in some ethnic groups. This study is performed to examine the association between TG/HDL-C and albuminuria. Methods: This cross-sectional study included 9094 adult subjects (4091 men, 5003 women) who were enrolled in the Korean Genomic Rural Cohort (KGRC) and aged 40. years or more. Albuminuria was defined as a urine albumin/creatinine ratio ≥ 30 mg/g. Participants were categorized into TG/HDL-C quartile. Results: Compared to the lowest TG/HDL-C quartile (< 1.94 in men, < 1.71 in women), the odds ratios (ORs) for albuminuria in participants who were categorized in the highest TG/HDL-C quartile (≥ 4.98 in men, ≥ 4.20 in women) were 1.30 (95% CI: 0.97-1.75) and 1.36 (1.03-1.79) in men and women, respectively, when adjusted for blood pressure and other covariates. In normotensive men and women, the ORs for albuminuria in the highest TG/HDL-C quartile were 1.58 (1.04-2.39) and 1.68 (1.15-2.45), respectively, even after fully adjusted. In contrast, TG/HDL-C was not associated with albuminuria in hypertensive subjects. Conclusions: TG/HDL-C was independently associated with increased prevalence of albuminuria in normotensive rural Korean subjects aged 40. years or more in KGRC.

Original languageEnglish
Pages (from-to)319-324
Number of pages6
JournalClinica Chimica Acta
Volume413
Issue number1-2
DOIs
Publication statusPublished - 2012 Jan 18

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Albuminuria
Rural Population
Albumins
Blood pressure
HDL Cholesterol
Creatinine
Triglycerides
Odds Ratio
Insulin
Ethnic Groups
Insulin Resistance
Cross-Sectional Studies
Urine
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Kang, Hee Taik ; Kim, Jong Koo ; Kim, Jang Young ; Linton, John A. ; Yoon, JinHa ; Koh, Sangbaek. / Independent association of TG/HDL-C with urinary albumin excretion in normotensive subjects in a rural Korean population. In: Clinica Chimica Acta. 2012 ; Vol. 413, No. 1-2. pp. 319-324.
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abstract = "Background: The ratio of triglycerides (TG, mg/dl) to high-density lipoprotein cholesterol (HDL-C, mg/dl) is a reliable indicator of insulin resistance and atherosclerotic diseases in some ethnic groups. This study is performed to examine the association between TG/HDL-C and albuminuria. Methods: This cross-sectional study included 9094 adult subjects (4091 men, 5003 women) who were enrolled in the Korean Genomic Rural Cohort (KGRC) and aged 40. years or more. Albuminuria was defined as a urine albumin/creatinine ratio ≥ 30 mg/g. Participants were categorized into TG/HDL-C quartile. Results: Compared to the lowest TG/HDL-C quartile (< 1.94 in men, < 1.71 in women), the odds ratios (ORs) for albuminuria in participants who were categorized in the highest TG/HDL-C quartile (≥ 4.98 in men, ≥ 4.20 in women) were 1.30 (95{\%} CI: 0.97-1.75) and 1.36 (1.03-1.79) in men and women, respectively, when adjusted for blood pressure and other covariates. In normotensive men and women, the ORs for albuminuria in the highest TG/HDL-C quartile were 1.58 (1.04-2.39) and 1.68 (1.15-2.45), respectively, even after fully adjusted. In contrast, TG/HDL-C was not associated with albuminuria in hypertensive subjects. Conclusions: TG/HDL-C was independently associated with increased prevalence of albuminuria in normotensive rural Korean subjects aged 40. years or more in KGRC.",
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Independent association of TG/HDL-C with urinary albumin excretion in normotensive subjects in a rural Korean population. / Kang, Hee Taik; Kim, Jong Koo; Kim, Jang Young; Linton, John A.; Yoon, JinHa; Koh, Sangbaek.

In: Clinica Chimica Acta, Vol. 413, No. 1-2, 18.01.2012, p. 319-324.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Independent association of TG/HDL-C with urinary albumin excretion in normotensive subjects in a rural Korean population

AU - Kang, Hee Taik

AU - Kim, Jong Koo

AU - Kim, Jang Young

AU - Linton, John A.

AU - Yoon, JinHa

AU - Koh, Sangbaek

PY - 2012/1/18

Y1 - 2012/1/18

N2 - Background: The ratio of triglycerides (TG, mg/dl) to high-density lipoprotein cholesterol (HDL-C, mg/dl) is a reliable indicator of insulin resistance and atherosclerotic diseases in some ethnic groups. This study is performed to examine the association between TG/HDL-C and albuminuria. Methods: This cross-sectional study included 9094 adult subjects (4091 men, 5003 women) who were enrolled in the Korean Genomic Rural Cohort (KGRC) and aged 40. years or more. Albuminuria was defined as a urine albumin/creatinine ratio ≥ 30 mg/g. Participants were categorized into TG/HDL-C quartile. Results: Compared to the lowest TG/HDL-C quartile (< 1.94 in men, < 1.71 in women), the odds ratios (ORs) for albuminuria in participants who were categorized in the highest TG/HDL-C quartile (≥ 4.98 in men, ≥ 4.20 in women) were 1.30 (95% CI: 0.97-1.75) and 1.36 (1.03-1.79) in men and women, respectively, when adjusted for blood pressure and other covariates. In normotensive men and women, the ORs for albuminuria in the highest TG/HDL-C quartile were 1.58 (1.04-2.39) and 1.68 (1.15-2.45), respectively, even after fully adjusted. In contrast, TG/HDL-C was not associated with albuminuria in hypertensive subjects. Conclusions: TG/HDL-C was independently associated with increased prevalence of albuminuria in normotensive rural Korean subjects aged 40. years or more in KGRC.

AB - Background: The ratio of triglycerides (TG, mg/dl) to high-density lipoprotein cholesterol (HDL-C, mg/dl) is a reliable indicator of insulin resistance and atherosclerotic diseases in some ethnic groups. This study is performed to examine the association between TG/HDL-C and albuminuria. Methods: This cross-sectional study included 9094 adult subjects (4091 men, 5003 women) who were enrolled in the Korean Genomic Rural Cohort (KGRC) and aged 40. years or more. Albuminuria was defined as a urine albumin/creatinine ratio ≥ 30 mg/g. Participants were categorized into TG/HDL-C quartile. Results: Compared to the lowest TG/HDL-C quartile (< 1.94 in men, < 1.71 in women), the odds ratios (ORs) for albuminuria in participants who were categorized in the highest TG/HDL-C quartile (≥ 4.98 in men, ≥ 4.20 in women) were 1.30 (95% CI: 0.97-1.75) and 1.36 (1.03-1.79) in men and women, respectively, when adjusted for blood pressure and other covariates. In normotensive men and women, the ORs for albuminuria in the highest TG/HDL-C quartile were 1.58 (1.04-2.39) and 1.68 (1.15-2.45), respectively, even after fully adjusted. In contrast, TG/HDL-C was not associated with albuminuria in hypertensive subjects. Conclusions: TG/HDL-C was independently associated with increased prevalence of albuminuria in normotensive rural Korean subjects aged 40. years or more in KGRC.

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DO - 10.1016/j.cca.2011.10.021

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