Independent inverse relationship between serum lycopene concentration and arterial stiffness

Oh Yoen Kim, Hyun Yang Yoe, Hyae Jin Kim, Ju Yeon Park, Ji Young Kim, Sang Hak Lee, Jin Hee Lee, Kang Pyo Lee, Yangsoo Jang, Jong Ho Lee

Research output: Contribution to journalArticle

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Abstract

Objective: Emerging evidence suggests a role of lycopene in the primary prevention of cardiovascular disease. This study aimed to investigate the association of serum lycopene concentration with brachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness and markers of oxidative stress and inflammation. Methods: healthy women (n = 264, 31-75 yrs) were classified into tertiles according to serum lycopene concentration. Multivariate linear regression analyses were used to assess the relationship between serum lycopene and baPWV. Results: Subjects in middle tertile (T2) and upper tertile (T3) had lower baPWV (1263 ± 23 and 1265 ± 14 cm/s vs. 1338 ± 21 cm/s; p = 0.009) and lower oxidized LDL (oxLDL) (53 ± 3 and 55 ± 3 U/L vs. 66 ± 3U/L; p < 0.001) than those in lower tertile (T1). Subjects in T3 showed higher LDL particle size (24.3 ± 0.08 nm vs. 24.0 ± 0.07 nm, p = 0.005) and lower C-reactive protein (hs-CRP) (0.80 ± 0.25 mg/dL vs. 1.27 ± 0.24 mg/dL, p = 0.015), compared with those in T1. Logistic regression analysis showed that baPWV decreased with the increment of lycopene concentration; log baPWV decreased by 0.21 cm/s (95% CI -0.168;-0.045, p = 0.001) per unit change in lycopene. After adjustment for age, BMI, smoking, drinking, menopause and blood pressure, the estimated effect was attenuated by 35%, but remained statistically significant [-0.13 cm/s (95% CI -0.112;-0.018, p = 0.006)]. Further adjustment for β-carotene, α-tocopherol, oxLDL, LDL particle size, and hs-CRP increased the strength of the association [β = -0.221 (95% CI -0.215;-0.012, p = 0.029)]. Conclusion: This study supports the presence of an independent inverse relationship between circulating lycopene and baPWV. Additionally, reduced oxidative modification of LDL may be one of mediators on the mechanisms how lycopene reduces arterial stiffness.

Original languageEnglish
Pages (from-to)581-586
Number of pages6
JournalAtherosclerosis
Volume208
Issue number2
DOIs
Publication statusPublished - 2010 Feb 1

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Vascular Stiffness
Pulse Wave Analysis
Ankle
Arm
Serum
Particle Size
Regression Analysis
Tocopherols
lycopene
Carotenoids
Primary Prevention
Menopause
C-Reactive Protein
Drinking
Linear Models
Oxidative Stress
Cardiovascular Diseases
Logistic Models
Smoking
oxidized low density lipoprotein

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Kim, Oh Yoen ; Yoe, Hyun Yang ; Kim, Hyae Jin ; Park, Ju Yeon ; Kim, Ji Young ; Lee, Sang Hak ; Lee, Jin Hee ; Lee, Kang Pyo ; Jang, Yangsoo ; Lee, Jong Ho. / Independent inverse relationship between serum lycopene concentration and arterial stiffness. In: Atherosclerosis. 2010 ; Vol. 208, No. 2. pp. 581-586.
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title = "Independent inverse relationship between serum lycopene concentration and arterial stiffness",
abstract = "Objective: Emerging evidence suggests a role of lycopene in the primary prevention of cardiovascular disease. This study aimed to investigate the association of serum lycopene concentration with brachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness and markers of oxidative stress and inflammation. Methods: healthy women (n = 264, 31-75 yrs) were classified into tertiles according to serum lycopene concentration. Multivariate linear regression analyses were used to assess the relationship between serum lycopene and baPWV. Results: Subjects in middle tertile (T2) and upper tertile (T3) had lower baPWV (1263 ± 23 and 1265 ± 14 cm/s vs. 1338 ± 21 cm/s; p = 0.009) and lower oxidized LDL (oxLDL) (53 ± 3 and 55 ± 3 U/L vs. 66 ± 3U/L; p < 0.001) than those in lower tertile (T1). Subjects in T3 showed higher LDL particle size (24.3 ± 0.08 nm vs. 24.0 ± 0.07 nm, p = 0.005) and lower C-reactive protein (hs-CRP) (0.80 ± 0.25 mg/dL vs. 1.27 ± 0.24 mg/dL, p = 0.015), compared with those in T1. Logistic regression analysis showed that baPWV decreased with the increment of lycopene concentration; log baPWV decreased by 0.21 cm/s (95{\%} CI -0.168;-0.045, p = 0.001) per unit change in lycopene. After adjustment for age, BMI, smoking, drinking, menopause and blood pressure, the estimated effect was attenuated by 35{\%}, but remained statistically significant [-0.13 cm/s (95{\%} CI -0.112;-0.018, p = 0.006)]. Further adjustment for β-carotene, α-tocopherol, oxLDL, LDL particle size, and hs-CRP increased the strength of the association [β = -0.221 (95{\%} CI -0.215;-0.012, p = 0.029)]. Conclusion: This study supports the presence of an independent inverse relationship between circulating lycopene and baPWV. Additionally, reduced oxidative modification of LDL may be one of mediators on the mechanisms how lycopene reduces arterial stiffness.",
author = "Kim, {Oh Yoen} and Yoe, {Hyun Yang} and Kim, {Hyae Jin} and Park, {Ju Yeon} and Kim, {Ji Young} and Lee, {Sang Hak} and Lee, {Jin Hee} and Lee, {Kang Pyo} and Yangsoo Jang and Lee, {Jong Ho}",
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Independent inverse relationship between serum lycopene concentration and arterial stiffness. / Kim, Oh Yoen; Yoe, Hyun Yang; Kim, Hyae Jin; Park, Ju Yeon; Kim, Ji Young; Lee, Sang Hak; Lee, Jin Hee; Lee, Kang Pyo; Jang, Yangsoo; Lee, Jong Ho.

In: Atherosclerosis, Vol. 208, No. 2, 01.02.2010, p. 581-586.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Independent inverse relationship between serum lycopene concentration and arterial stiffness

AU - Kim, Oh Yoen

AU - Yoe, Hyun Yang

AU - Kim, Hyae Jin

AU - Park, Ju Yeon

AU - Kim, Ji Young

AU - Lee, Sang Hak

AU - Lee, Jin Hee

AU - Lee, Kang Pyo

AU - Jang, Yangsoo

AU - Lee, Jong Ho

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Objective: Emerging evidence suggests a role of lycopene in the primary prevention of cardiovascular disease. This study aimed to investigate the association of serum lycopene concentration with brachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness and markers of oxidative stress and inflammation. Methods: healthy women (n = 264, 31-75 yrs) were classified into tertiles according to serum lycopene concentration. Multivariate linear regression analyses were used to assess the relationship between serum lycopene and baPWV. Results: Subjects in middle tertile (T2) and upper tertile (T3) had lower baPWV (1263 ± 23 and 1265 ± 14 cm/s vs. 1338 ± 21 cm/s; p = 0.009) and lower oxidized LDL (oxLDL) (53 ± 3 and 55 ± 3 U/L vs. 66 ± 3U/L; p < 0.001) than those in lower tertile (T1). Subjects in T3 showed higher LDL particle size (24.3 ± 0.08 nm vs. 24.0 ± 0.07 nm, p = 0.005) and lower C-reactive protein (hs-CRP) (0.80 ± 0.25 mg/dL vs. 1.27 ± 0.24 mg/dL, p = 0.015), compared with those in T1. Logistic regression analysis showed that baPWV decreased with the increment of lycopene concentration; log baPWV decreased by 0.21 cm/s (95% CI -0.168;-0.045, p = 0.001) per unit change in lycopene. After adjustment for age, BMI, smoking, drinking, menopause and blood pressure, the estimated effect was attenuated by 35%, but remained statistically significant [-0.13 cm/s (95% CI -0.112;-0.018, p = 0.006)]. Further adjustment for β-carotene, α-tocopherol, oxLDL, LDL particle size, and hs-CRP increased the strength of the association [β = -0.221 (95% CI -0.215;-0.012, p = 0.029)]. Conclusion: This study supports the presence of an independent inverse relationship between circulating lycopene and baPWV. Additionally, reduced oxidative modification of LDL may be one of mediators on the mechanisms how lycopene reduces arterial stiffness.

AB - Objective: Emerging evidence suggests a role of lycopene in the primary prevention of cardiovascular disease. This study aimed to investigate the association of serum lycopene concentration with brachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness and markers of oxidative stress and inflammation. Methods: healthy women (n = 264, 31-75 yrs) were classified into tertiles according to serum lycopene concentration. Multivariate linear regression analyses were used to assess the relationship between serum lycopene and baPWV. Results: Subjects in middle tertile (T2) and upper tertile (T3) had lower baPWV (1263 ± 23 and 1265 ± 14 cm/s vs. 1338 ± 21 cm/s; p = 0.009) and lower oxidized LDL (oxLDL) (53 ± 3 and 55 ± 3 U/L vs. 66 ± 3U/L; p < 0.001) than those in lower tertile (T1). Subjects in T3 showed higher LDL particle size (24.3 ± 0.08 nm vs. 24.0 ± 0.07 nm, p = 0.005) and lower C-reactive protein (hs-CRP) (0.80 ± 0.25 mg/dL vs. 1.27 ± 0.24 mg/dL, p = 0.015), compared with those in T1. Logistic regression analysis showed that baPWV decreased with the increment of lycopene concentration; log baPWV decreased by 0.21 cm/s (95% CI -0.168;-0.045, p = 0.001) per unit change in lycopene. After adjustment for age, BMI, smoking, drinking, menopause and blood pressure, the estimated effect was attenuated by 35%, but remained statistically significant [-0.13 cm/s (95% CI -0.112;-0.018, p = 0.006)]. Further adjustment for β-carotene, α-tocopherol, oxLDL, LDL particle size, and hs-CRP increased the strength of the association [β = -0.221 (95% CI -0.215;-0.012, p = 0.029)]. Conclusion: This study supports the presence of an independent inverse relationship between circulating lycopene and baPWV. Additionally, reduced oxidative modification of LDL may be one of mediators on the mechanisms how lycopene reduces arterial stiffness.

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