Indications for a second prostate biopsy in patients suspected with prostate cancer after an initial negative prostate biopsy

Kwang Suk Lee, Kyo Chul Koo, Kang Su Cho, Seung Hwan Lee, Woong Kyu Han, Young Deuk Choi, Sung Joon Hong, Sang Un Park, Suk Young Lee, Woo Jin Ko, Young Sig Kim, Byung Ha Chung

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background The present study aimed to evaluate the indications for a second prostate biopsy in patients suspected with prostate cancer after an initial negative prostate biopsy. Methods The present study included 421 patients who underwent repeat prostate biopsy between January 2007 and December 2015 at three hospitals. Clinicopathological data, including patient age, body mass index, history of prostate biopsy, prostate volume, prostate-specific antigen (PSA) level, PSA density, PSA velocity, and PSA fluctuation patterns, were analyzed. The patients were stratified into two groups based on the first PSA pattern (increase/decrease) within 1 year after the initial negative prostate biopsy. Results Prostate cancer was detected in 100 (23.8%) of the 421 patients at the second prostate biopsy. In patients with a PSA decrease at the first follow-up, prostate volume and number of increases in the PSA level from the initial prostate biopsy were predictors for prostate cancer diagnosis at the second prostate biopsy. In patients with a steady PSA increase after the initial prostate biopsy, prostate volume and number of biopsy cores were predictors for prostate cancer diagnosis at the second prostate biopsy. Conclusion The indications for a second prostate biopsy are a low prostate volume and a high number of increases in the PSA level among patients with a PSA decrease at the first follow-up and a low prostate volume and a high number of biopsy cores among patients with a PSA increase at the first follow-up.

Original languageEnglish
Pages (from-to)24-28
Number of pages5
JournalProstate International
Volume5
Issue number1
DOIs
Publication statusPublished - 2017 Mar 1

All Science Journal Classification (ASJC) codes

  • Urology

Fingerprint Dive into the research topics of 'Indications for a second prostate biopsy in patients suspected with prostate cancer after an initial negative prostate biopsy'. Together they form a unique fingerprint.

  • Cite this