Indium-111-pentetreotide imaging in intra-axial brain tumors: Comparison with thallium-201 SPECT and MRI

Doo Lee Jong Doo Lee, Ik Kim Dong Ik Kim, Tae Lee Jong Tae Lee, Woo Chang Jin Woo Chang, Yun Park Chang Yun Park

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Highly undifferentiated glial tumors do not express somatostatin receptors (SSR) in contrast to low-grade astrocytomas which contain SSR. To differentiate a malignant glioma from a low-grade astrocytoma and to distinguish an SSR-positive intra-axial brain tumor from an SSR negative one, 111In-pentetreotide brain SPECT was prospectively undertaken. Methods: Eight patients with intra-axial brain tumors (three glioblastoma multiforme, one low-grade astrocytoma, one lymphoma, one medulloblastoma, one neurocytoma and one metastatic tumor) were studied. Thallium-201 and 111In- pentetreotide brain SPECT were performed with a 3- to 4-day interval before surgery. The SPECT findings were compared with those of Gd-enhanced MRI. Results: Increased uptake of 111In-pentetreotide was observed in all of the patients with glioblastoma multiforme (Grade +++ in two and Grade + in one) despite lack of SSR. Low-grade astrocytoma exhibited minimal uptake of 111In-pentetreotide (Grade +). Remaining tumors had intense uptake of 111In-pentetreotide. Thallium-201 SPECT showed similar findings to those of 111In-pentetreotide scintigraphy except in two patients with glioblastoma multiforme: One with 201Tl negative scan showed increased uptake of 111In-pentetreotide and the other showed increased thallium uptake but minimal uptake of 111In-pentetreotide. The uptake pattern of both 201Tl and 111In-pentetreotide appeared to correlate with Gd- enhanced MRI. Conclusion: Indium-111-pentetreotide scintigraphy is sensitive in the detection of intra-axial brain tumors; however, it has no role in assessing the tumor grading and in the definition of the receptor profile.

Original languageEnglish
Pages (from-to)537-541
Number of pages5
JournalJournal of Nuclear Medicine
Volume36
Issue number4
Publication statusPublished - 1995 Jan 1

Fingerprint

Thallium
Single-Photon Emission-Computed Tomography
Brain Neoplasms
Somatostatin Receptors
Astrocytoma
Glioblastoma
Radionuclide Imaging
Neurocytoma
pentetreotide
Neoplasms
Medulloblastoma
Neoplasm Grading
Brain
Glioma
Neuroglia
Lymphoma

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Jong Doo Lee, D. L., Dong Ik Kim, I. K., Jong Tae Lee, T. L., Jin Woo Chang, W. C., & Chang Yun Park, Y. P. (1995). Indium-111-pentetreotide imaging in intra-axial brain tumors: Comparison with thallium-201 SPECT and MRI. Journal of Nuclear Medicine, 36(4), 537-541.
Jong Doo Lee, Doo Lee ; Dong Ik Kim, Ik Kim ; Jong Tae Lee, Tae Lee ; Jin Woo Chang, Woo Chang ; Chang Yun Park, Yun Park. / Indium-111-pentetreotide imaging in intra-axial brain tumors : Comparison with thallium-201 SPECT and MRI. In: Journal of Nuclear Medicine. 1995 ; Vol. 36, No. 4. pp. 537-541.
@article{a142b1f82aad467ea3cd8f4330381545,
title = "Indium-111-pentetreotide imaging in intra-axial brain tumors: Comparison with thallium-201 SPECT and MRI",
abstract = "Highly undifferentiated glial tumors do not express somatostatin receptors (SSR) in contrast to low-grade astrocytomas which contain SSR. To differentiate a malignant glioma from a low-grade astrocytoma and to distinguish an SSR-positive intra-axial brain tumor from an SSR negative one, 111In-pentetreotide brain SPECT was prospectively undertaken. Methods: Eight patients with intra-axial brain tumors (three glioblastoma multiforme, one low-grade astrocytoma, one lymphoma, one medulloblastoma, one neurocytoma and one metastatic tumor) were studied. Thallium-201 and 111In- pentetreotide brain SPECT were performed with a 3- to 4-day interval before surgery. The SPECT findings were compared with those of Gd-enhanced MRI. Results: Increased uptake of 111In-pentetreotide was observed in all of the patients with glioblastoma multiforme (Grade +++ in two and Grade + in one) despite lack of SSR. Low-grade astrocytoma exhibited minimal uptake of 111In-pentetreotide (Grade +). Remaining tumors had intense uptake of 111In-pentetreotide. Thallium-201 SPECT showed similar findings to those of 111In-pentetreotide scintigraphy except in two patients with glioblastoma multiforme: One with 201Tl negative scan showed increased uptake of 111In-pentetreotide and the other showed increased thallium uptake but minimal uptake of 111In-pentetreotide. The uptake pattern of both 201Tl and 111In-pentetreotide appeared to correlate with Gd- enhanced MRI. Conclusion: Indium-111-pentetreotide scintigraphy is sensitive in the detection of intra-axial brain tumors; however, it has no role in assessing the tumor grading and in the definition of the receptor profile.",
author = "{Jong Doo Lee}, {Doo Lee} and {Dong Ik Kim}, {Ik Kim} and {Jong Tae Lee}, {Tae Lee} and {Jin Woo Chang}, {Woo Chang} and {Chang Yun Park}, {Yun Park}",
year = "1995",
month = "1",
day = "1",
language = "English",
volume = "36",
pages = "537--541",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "4",

}

Jong Doo Lee, DL, Dong Ik Kim, IK, Jong Tae Lee, TL, Jin Woo Chang, WC & Chang Yun Park, YP 1995, 'Indium-111-pentetreotide imaging in intra-axial brain tumors: Comparison with thallium-201 SPECT and MRI', Journal of Nuclear Medicine, vol. 36, no. 4, pp. 537-541.

Indium-111-pentetreotide imaging in intra-axial brain tumors : Comparison with thallium-201 SPECT and MRI. / Jong Doo Lee, Doo Lee; Dong Ik Kim, Ik Kim; Jong Tae Lee, Tae Lee; Jin Woo Chang, Woo Chang; Chang Yun Park, Yun Park.

In: Journal of Nuclear Medicine, Vol. 36, No. 4, 01.01.1995, p. 537-541.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Indium-111-pentetreotide imaging in intra-axial brain tumors

T2 - Comparison with thallium-201 SPECT and MRI

AU - Jong Doo Lee, Doo Lee

AU - Dong Ik Kim, Ik Kim

AU - Jong Tae Lee, Tae Lee

AU - Jin Woo Chang, Woo Chang

AU - Chang Yun Park, Yun Park

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Highly undifferentiated glial tumors do not express somatostatin receptors (SSR) in contrast to low-grade astrocytomas which contain SSR. To differentiate a malignant glioma from a low-grade astrocytoma and to distinguish an SSR-positive intra-axial brain tumor from an SSR negative one, 111In-pentetreotide brain SPECT was prospectively undertaken. Methods: Eight patients with intra-axial brain tumors (three glioblastoma multiforme, one low-grade astrocytoma, one lymphoma, one medulloblastoma, one neurocytoma and one metastatic tumor) were studied. Thallium-201 and 111In- pentetreotide brain SPECT were performed with a 3- to 4-day interval before surgery. The SPECT findings were compared with those of Gd-enhanced MRI. Results: Increased uptake of 111In-pentetreotide was observed in all of the patients with glioblastoma multiforme (Grade +++ in two and Grade + in one) despite lack of SSR. Low-grade astrocytoma exhibited minimal uptake of 111In-pentetreotide (Grade +). Remaining tumors had intense uptake of 111In-pentetreotide. Thallium-201 SPECT showed similar findings to those of 111In-pentetreotide scintigraphy except in two patients with glioblastoma multiforme: One with 201Tl negative scan showed increased uptake of 111In-pentetreotide and the other showed increased thallium uptake but minimal uptake of 111In-pentetreotide. The uptake pattern of both 201Tl and 111In-pentetreotide appeared to correlate with Gd- enhanced MRI. Conclusion: Indium-111-pentetreotide scintigraphy is sensitive in the detection of intra-axial brain tumors; however, it has no role in assessing the tumor grading and in the definition of the receptor profile.

AB - Highly undifferentiated glial tumors do not express somatostatin receptors (SSR) in contrast to low-grade astrocytomas which contain SSR. To differentiate a malignant glioma from a low-grade astrocytoma and to distinguish an SSR-positive intra-axial brain tumor from an SSR negative one, 111In-pentetreotide brain SPECT was prospectively undertaken. Methods: Eight patients with intra-axial brain tumors (three glioblastoma multiforme, one low-grade astrocytoma, one lymphoma, one medulloblastoma, one neurocytoma and one metastatic tumor) were studied. Thallium-201 and 111In- pentetreotide brain SPECT were performed with a 3- to 4-day interval before surgery. The SPECT findings were compared with those of Gd-enhanced MRI. Results: Increased uptake of 111In-pentetreotide was observed in all of the patients with glioblastoma multiforme (Grade +++ in two and Grade + in one) despite lack of SSR. Low-grade astrocytoma exhibited minimal uptake of 111In-pentetreotide (Grade +). Remaining tumors had intense uptake of 111In-pentetreotide. Thallium-201 SPECT showed similar findings to those of 111In-pentetreotide scintigraphy except in two patients with glioblastoma multiforme: One with 201Tl negative scan showed increased uptake of 111In-pentetreotide and the other showed increased thallium uptake but minimal uptake of 111In-pentetreotide. The uptake pattern of both 201Tl and 111In-pentetreotide appeared to correlate with Gd- enhanced MRI. Conclusion: Indium-111-pentetreotide scintigraphy is sensitive in the detection of intra-axial brain tumors; however, it has no role in assessing the tumor grading and in the definition of the receptor profile.

UR - http://www.scopus.com/inward/record.url?scp=0028965919&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028965919&partnerID=8YFLogxK

M3 - Article

C2 - 7699438

AN - SCOPUS:0028965919

VL - 36

SP - 537

EP - 541

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

SN - 0161-5505

IS - 4

ER -