Indium-111-pentetreotide imaging in intra-axial brain tumors: Comparison with thallium-201 SPECT and MRI

Doo Lee Jong Doo Lee, Ik Kim Dong Ik Kim, Tae Lee Jong Tae Lee, Woo Chang Jin Woo Chang, Yun Park Chang Yun Park

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Abstract

Highly undifferentiated glial tumors do not express somatostatin receptors (SSR) in contrast to low-grade astrocytomas which contain SSR. To differentiate a malignant glioma from a low-grade astrocytoma and to distinguish an SSR-positive intra-axial brain tumor from an SSR negative one, 111In-pentetreotide brain SPECT was prospectively undertaken. Methods: Eight patients with intra-axial brain tumors (three glioblastoma multiforme, one low-grade astrocytoma, one lymphoma, one medulloblastoma, one neurocytoma and one metastatic tumor) were studied. Thallium-201 and 111In- pentetreotide brain SPECT were performed with a 3- to 4-day interval before surgery. The SPECT findings were compared with those of Gd-enhanced MRI. Results: Increased uptake of 111In-pentetreotide was observed in all of the patients with glioblastoma multiforme (Grade +++ in two and Grade + in one) despite lack of SSR. Low-grade astrocytoma exhibited minimal uptake of 111In-pentetreotide (Grade +). Remaining tumors had intense uptake of 111In-pentetreotide. Thallium-201 SPECT showed similar findings to those of 111In-pentetreotide scintigraphy except in two patients with glioblastoma multiforme: One with 201Tl negative scan showed increased uptake of 111In-pentetreotide and the other showed increased thallium uptake but minimal uptake of 111In-pentetreotide. The uptake pattern of both 201Tl and 111In-pentetreotide appeared to correlate with Gd- enhanced MRI. Conclusion: Indium-111-pentetreotide scintigraphy is sensitive in the detection of intra-axial brain tumors; however, it has no role in assessing the tumor grading and in the definition of the receptor profile.

Original languageEnglish
Pages (from-to)537-541
Number of pages5
JournalJournal of Nuclear Medicine
Volume36
Issue number4
Publication statusPublished - 1995 Jan 1

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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    Jong Doo Lee, D. L., Dong Ik Kim, I. K., Jong Tae Lee, T. L., Jin Woo Chang, W. C., & Chang Yun Park, Y. P. (1995). Indium-111-pentetreotide imaging in intra-axial brain tumors: Comparison with thallium-201 SPECT and MRI. Journal of Nuclear Medicine, 36(4), 537-541.