A convenient and efficient method was developed for the synthesis of alkyl phenyl selenides, sulfides, and selenoesters in one-pot reaction by using indium metal. The reaction showed the selectivity for tert-alkyl, benzylic, and allylic halides over primary and secondary alkyl halides. For the reaction of primary and secondary alkyl iodides and bromides, the yields of selenides were improved by the addition of a catalytic amount of iodine.
Bibliographical noteFunding Information:
This work was supported by the Center for Bioactive Molecular Hybrids and Yonsei University. W.M. is thankful to Thailand Research Fund for the 2004 Royal Golden Jubilee Ph.D. research assistant fellowship.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry