Indium-mediated coupling reactions of acyl chlorides and amines for the synthesis of amide bonds are described. The reaction afforded high yields of the desired amides under mild and neutral conditions, and it was applicable also to the preparation of peptides without epimerization.
Bibliographical noteFunding Information:
This work was supported by Center for Bioactive Molecular Hybrids at Yonsei University.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry