-paradol, a pungent phenolic substance found in ginger and other Zingiberaceae plants, has been demonstrated to be an effective inhibitor of tumor promotion in mouse skin carcinogenesis. In the present study, we found that -paradol and other structurally related derivatives, -paradol, -dehydroparadol, -dehydroparadol, and -dehydroparadol, with the exception of -paradol induce apoptosis in an oral squamous carcinoma cell line, KB, in a dose-dependent manner. -paradol and -dehydroparadol exhibited a similar extent of cytotoxicity to that of -paradol. -Dehydroparadol and -dehydroparadol appeared to be more potent, with an IC50 less than 40 μM. Treatment of KB cells with an apoptosis-inducing concentration of -dehydroparadol caused induction of proteolytic cleavage of pro-caspase-3. These results suggest that -paradol and structurally related derivatives induce apoptosis through a caspase-3-dependent mechanism.
Bibliographical noteFunding Information:
This study was supported by the Korea Science and Engineering Foundation (98-0403-07-01-3) and BK21 Project for Medical Sciences. We thank Jung Yoo Choi for editorial assistance.
All Science Journal Classification (ASJC) codes
- Cancer Research