Induction of apoptosis and caspase-3 activation by chemopreventive [6]-paradol and structurally related compounds in KB cells

Young Sam Keum, Jin Kim, Keun Hyung Lee, Kwang Kyun Park, Young Joon Surh, Jong Min Lee, Sang Sup Lee, Jung Hoon Yoon, So Yeon Joo, In Ho Cha, Jong In Yook

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Abstract

[6]-paradol, a pungent phenolic substance found in ginger and other Zingiberaceae plants, has been demonstrated to be an effective inhibitor of tumor promotion in mouse skin carcinogenesis. In the present study, we found that [6]-paradol and other structurally related derivatives, [10]-paradol, [3]-dehydroparadol, [6]-dehydroparadol, and [10]-dehydroparadol, with the exception of [3]-paradol induce apoptosis in an oral squamous carcinoma cell line, KB, in a dose-dependent manner. [10]-paradol and [10]-dehydroparadol exhibited a similar extent of cytotoxicity to that of [6]-paradol. [6]-Dehydroparadol and [3]-dehydroparadol appeared to be more potent, with an IC50 less than 40 μM. Treatment of KB cells with an apoptosis-inducing concentration of [6]-dehydroparadol caused induction of proteolytic cleavage of pro-caspase-3. These results suggest that [6]-paradol and structurally related derivatives induce apoptosis through a caspase-3-dependent mechanism.

Original languageEnglish
Pages (from-to)41-47
Number of pages7
JournalCancer Letters
Volume177
Issue number1
DOIs
Publication statusPublished - 2002 Mar 8

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Keum, Y. S., Kim, J., Lee, K. H., Park, K. K., Surh, Y. J., Lee, J. M., Lee, S. S., Yoon, J. H., Joo, S. Y., Cha, I. H., & Yook, J. I. (2002). Induction of apoptosis and caspase-3 activation by chemopreventive [6]-paradol and structurally related compounds in KB cells. Cancer Letters, 177(1), 41-47. https://doi.org/10.1016/S0304-3835(01)00781-9