Induction of Neuronal Cell Death by Rab5A-dependent Endocytosis of α-Synuclein

Jee Young Sung, Jongsun Kim, Seung R. Paik, Jeon Han Park, Young Soo Ahn, Kwang Chul Chung

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

The presynaptic α-synuclein is a prime suspect for contributing to Lewy pathology and clinical aspects of diseases, including Parkinson's disease, dementia with Lewy bodies, and a Lewy body variant of Alzheimer's disease. Here we examined the pathogenic mechanism of neuronal cell death induced by α-synuclein. The exogenous addition of α-synuclein caused a marked decrease of cell viability in primary and immortalized neuronal cells. The neuronal cell death appeared to be correlated with the Rab5A-specific endocytosis of α-synuclein that subsequently caused the formation of Lewy body-like intracytoplasmic inclusions. This was further supported by the fact that the expression of GTPase-deficient Rab5A resulted in a significant decrease of its cytotoxicity as a result of incomplete endocytosis of α-synuclein.

Original languageEnglish
Pages (from-to)27441-27448
Number of pages8
JournalJournal of Biological Chemistry
Volume276
Issue number29
DOIs
Publication statusPublished - 2001 Jul 20

Fingerprint

Synucleins
Cell death
Endocytosis
Cell Death
Lewy Bodies
Lewy Body Disease
Clinical Pathology
GTP Phosphohydrolases
Pathology
Cytotoxicity
Parkinson Disease
Cell Survival
Cells

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Sung, Jee Young ; Kim, Jongsun ; Paik, Seung R. ; Park, Jeon Han ; Ahn, Young Soo ; Chung, Kwang Chul. / Induction of Neuronal Cell Death by Rab5A-dependent Endocytosis of α-Synuclein. In: Journal of Biological Chemistry. 2001 ; Vol. 276, No. 29. pp. 27441-27448.
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Induction of Neuronal Cell Death by Rab5A-dependent Endocytosis of α-Synuclein. / Sung, Jee Young; Kim, Jongsun; Paik, Seung R.; Park, Jeon Han; Ahn, Young Soo; Chung, Kwang Chul.

In: Journal of Biological Chemistry, Vol. 276, No. 29, 20.07.2001, p. 27441-27448.

Research output: Contribution to journalArticle

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