Inertial effects on cylindrical particle migration in linear shear flow near a wall

Dae Kyung Kim, Ji Yeon Hyun, Sung Chul Kim, Hansung Kim, Sei Young Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Micro-/nanoparticle-based systems are regarded as one of the possible candidates due to the engineerability and multifunctionality to maximize the accumulation of the nano-/microparticle-based drug delivery system on the target. Recent advances in nanotechnology enable the fabrication of diverse particle shapes from simple spherical particles to more complex shapes. The particle dynamics in blood flow and endocytosis characteristics of non-spherical particles change as the non-sphericity effect increases. We used a numerical approach to investigate the particle dynamics in linear shear flow near a wall. We examined the dynamics of slender cylindrical particles with aspect ratio γ = 5.0 in terms of particle trajectory, velocity, and force variation for different Stokes numbers over time. We identified the rotating inertia of particle near a wall as the source of inertial migration toward the wall. The drift velocity of slender cylindrical particles is comparable to that of discoidal particles. We discuss the possibilities and limitations of using slender cylindrical particles as a drug delivery system.

Original languageEnglish
Article number75
JournalMicrofluidics and Nanofluidics
Volume20
Issue number5
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

Shear flow
shear flow
Nanotechnology
Aspect ratio
Blood
Trajectories
Nanoparticles
Fabrication
delivery
drugs
particle trajectories
flow characteristics
microparticles
blood flow
nanotechnology
Drug Delivery Systems
inertia
aspect ratio
nanoparticles
fabrication

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Materials Chemistry

Cite this

Kim, Dae Kyung ; Hyun, Ji Yeon ; Kim, Sung Chul ; Kim, Hansung ; Lee, Sei Young. / Inertial effects on cylindrical particle migration in linear shear flow near a wall. In: Microfluidics and Nanofluidics. 2016 ; Vol. 20, No. 5.
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Inertial effects on cylindrical particle migration in linear shear flow near a wall. / Kim, Dae Kyung; Hyun, Ji Yeon; Kim, Sung Chul; Kim, Hansung; Lee, Sei Young.

In: Microfluidics and Nanofluidics, Vol. 20, No. 5, 75, 01.01.2016.

Research output: Contribution to journalArticle

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