Inflammation after Ischemic stroke: The role of leukocytes and glial cells

Jong Youl Kim, Joohyun Park, Ji Young Chang, Sa Hyun Kim, Jong Eun Lee

Research output: Contribution to journalReview article

63 Citations (Scopus)

Abstract

The immune response after stroke is known to play a major role in ischemic brain pathobiology. The inflammatory signals released by immune mediators activated by brain injury sets off a complex series of biochemical and molecular events which have been increasingly recognized as a key contributor to neuronal cell death. The primary immune mediators involved are glial cells and infiltrating leukocytes, including neutrophils, monocytes and lymphocyte. After ischemic stroke, activation of glial cells and subsequent release of pro- and anti-inflammatory signals are important for modulating both neuronal cell damage and wound healing. Infiltrated leukocytes release inflammatory mediators into the site of the lesion, thereby exacerbating brain injury. This review describes how the roles of glial cells and circulating leukocytes are a double-edged sword for neuroinflammation by focusing on their detrimental and protective effects in ischemic stroke. Here, we will focus on underlying characterize of glial cells and leukocytes under inflammation after ischemic stroke.

Original languageEnglish
Pages (from-to)241-251
Number of pages11
JournalExperimental Neurobiology
Volume25
Issue number5
DOIs
Publication statusPublished - 2016 Oct 1

Fingerprint

Neuroglia
Leukocytes
Stroke
Inflammation
Brain Injuries
Wound Healing
Monocytes
Neutrophils
Cell Death
Anti-Inflammatory Agents
Lymphocytes
Brain

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Kim, Jong Youl ; Park, Joohyun ; Chang, Ji Young ; Kim, Sa Hyun ; Lee, Jong Eun. / Inflammation after Ischemic stroke : The role of leukocytes and glial cells. In: Experimental Neurobiology. 2016 ; Vol. 25, No. 5. pp. 241-251.
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Inflammation after Ischemic stroke : The role of leukocytes and glial cells. / Kim, Jong Youl; Park, Joohyun; Chang, Ji Young; Kim, Sa Hyun; Lee, Jong Eun.

In: Experimental Neurobiology, Vol. 25, No. 5, 01.10.2016, p. 241-251.

Research output: Contribution to journalReview article

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