@inproceedings{b5190d3fc22642eb99097d442f10a38d,
title = "Inflammatory mimetic microfluidic system for T cell binding activity screening",
abstract = "Leucocytes adhesion to endothelium by way of surface molecules such as E-selectin and intercellular adhesion molecule-1 (ICAM-1) is a significant event in inflammation and cancer metastasis. Here, we present an inflammatory mimetic microfluidic system, which can easily monitor the binding difference or change of leucocytes to cell adhesion molecules of human umbilical vein endothelial cells (HUVECs) under physiological conditions. The inflammatory mimetic microfluidic chip was fabricated by immobilization of E-selectin and ICAM-1 in the microfluidic system. Since this system can esily detect the change of T cell binding activity by immunomodulator, it is useful as high throughput drug screening system.",
author = "Moon, {Won Kang} and Shin, {Min Kyeong} and Kwang Lee and Kim, {Sung Kyu} and Kim, {Jung Dong} and Kim, {Mi Roo} and Lee, {Chang Yeol} and Hyungil Jung",
year = "2009",
language = "English",
isbn = "9780979806421",
series = "Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "1620--1622",
booktitle = "Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
note = "13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 ; Conference date: 01-11-2009 Through 05-11-2009",
}
