Abstract
Leucocytes adhesion to endothelium by way of surface molecules such as E-selectin and intercellular adhesion molecule-1 (ICAM-1) is a significant event in inflammation and cancer metastasis. Here, we present an inflammatory mimetic microfluidic system, which can easily monitor the binding difference or change of leucocytes to cell adhesion molecules of human umbilical vein endothelial cells (HUVECs) under physiological conditions. The inflammatory mimetic microfluidic chip was fabricated by immobilization of E-selectin and ICAM-1 in the microfluidic system. Since this system can esily detect the change of T cell binding activity by immunomodulator, it is useful as high throughput drug screening system.
| Original language | English |
|---|---|
| Title of host publication | Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 1620-1622 |
| Number of pages | 3 |
| ISBN (Print) | 9780979806421 |
| Publication status | Published - 2009 |
| Event | 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 - Jeju, Korea, Republic of Duration: 2009 Nov 1 → 2009 Nov 5 |
Publication series
| Name | Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
|---|
Other
| Other | 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 |
|---|---|
| Country | Korea, Republic of |
| City | Jeju |
| Period | 09/11/1 → 09/11/5 |
All Science Journal Classification (ASJC) codes
- Chemical Engineering (miscellaneous)
- Bioengineering
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Cite this
Moon, W. K., Shin, M. K., Lee, K., Kim, S. K., Kim, J. D., Kim, M. R., Lee, C. Y., & Jung, H. (2009). Inflammatory mimetic microfluidic system for T cell binding activity screening. In Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1620-1622). (Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.