Inflammatory mimetic microfluidic system for T cell binding activity screening

Won Kang Moon, Min Kyeong Shin, Kwang Lee, Sung Kyu Kim, Jung Dong Kim, Mi Roo Kim, Chang Yeol Lee, Hyungil Jung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Leucocytes adhesion to endothelium by way of surface molecules such as E-selectin and intercellular adhesion molecule-1 (ICAM-1) is a significant event in inflammation and cancer metastasis. Here, we present an inflammatory mimetic microfluidic system, which can easily monitor the binding difference or change of leucocytes to cell adhesion molecules of human umbilical vein endothelial cells (HUVECs) under physiological conditions. The inflammatory mimetic microfluidic chip was fabricated by immobilization of E-selectin and ICAM-1 in the microfluidic system. Since this system can esily detect the change of T cell binding activity by immunomodulator, it is useful as high throughput drug screening system.

Original languageEnglish
Title of host publicationProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1620-1622
Number of pages3
ISBN (Print)9780979806421
Publication statusPublished - 2009
Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 - Jeju, Korea, Republic of
Duration: 2009 Nov 12009 Nov 5

Publication series

NameProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Other

Other13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009
CountryKorea, Republic of
CityJeju
Period09/11/109/11/5

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Moon, W. K., Shin, M. K., Lee, K., Kim, S. K., Kim, J. D., Kim, M. R., Lee, C. Y., & Jung, H. (2009). Inflammatory mimetic microfluidic system for T cell binding activity screening. In Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1620-1622). (Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.