Influence of a microscopic positive proximal margin in the treatment of gastric adenocarcinoma of the cardia

Jian Guo Shen, Jae Ho Cheong, Woo Jin Hyung, Junuk Kim, Seung Ho Choi, Sung Hoon Noh

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26 Citations (Scopus)


Aim: To investigate the influence of a positive proximal margin in total gastrectomy patients with gastric adenocarcinoma of the cardia. Methods: Medical records of 191 patients with total gastrectomies for adenocarcinoma of the cardia between 1995 and 2000 were reviewed. The clinicopathologic features associated with a positive margin were determined, and the predictors for survival were analyzed. Results: The incidence of positive proximal margin was 8.4% (16/191). The positive margins were associated with advanced diseases. The tumor size and the depth of tumor invasion were independent risk factors for a positive margin. The mean survival in the positive margin group was 33.9 mo as compared with 62.4 mo in the negative group (P < 0.001). However, the difference in survival lost significance in subgroup analysis according to stage. Multivariate analysis identified that a positive margin was not an independent prognostic factor for survival. Conclusion: A positive margin is more of an indication of advanced disease in patients with gastric adenocarcinoma of the cardia rather than an independent prognostic factor for survival.

Original languageEnglish
Pages (from-to)3883-3886
Number of pages4
JournalWorld Journal of Gastroenterology
Issue number24
Publication statusPublished - 2006 Jun 28


All Science Journal Classification (ASJC) codes

  • Gastroenterology

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