Influence of age and visceral fat area on plasma adiponectin concentrations in women with normal glucose tolerance

Soo Jeong Koh, Yae Jung Hyun, So Yeon Choi, Jey Sook Chae, Ji Young Kim, Sungha Park, Chul Min Ahn, Yangsoo Jang, Jong Ho Lee

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: Age-related adiponectin concentration has been discrepantly reported. We investigated the distribution of adiponectin by age in healthy women with normal glucose tolerance (NGT) and the relationship of adiponectin with visceral fat area (VFA). Methods: Three-hundred fifty-nine women (age: 38 ± 0.6 years, BMI: 26.5 ± 0.2 kg/m2) were categorized into 4 age-groups: 20-29, 30-39, 40-49, and 50-64 years. Computed tomography was performed to measure abdominal fat area and adiponectin, TNF-α, interleukin-6 (IL-6), CRP, insulin, free fatty acid (FFA), and blood urea nitrogen (BUN) were determined. Results: No significant differences were observed in BMI, total body fat percent and concentrations of insulin, IL-6 and CRP among age-groups. Waist circumference, total fat area at L4, and FFA were significantly higher only in postmenopausal women than in previous decades of premenopausal women. VFA, adiponectin and TNF-α concentrations are significantly higher in older women than in younger women. Higher adiponectin concentration in older women was clearly shown even after adjustment for VFA (P < 0.05). Age per se was positively correlated with plasma adiponectin concentrations (r = 0.21, P < 0.001) and these relationship became stronger (r = 0.36, P < 0.001) after controlled for VFA. VFA was negatively correlated with adiponectin (r = - 0.16, P < 0.01) in total studied population. However, when analyzed subgroups separately, a strong negative correlation (r = - 0.37, P < 0.001) was found in younger women (< 40 years), while a weak significant relationship (r = - 0.18, P < 0.05) was found in older women (≥ 40 years). In a multiple stepwise regression model to predict adiponectin, only age and VFA remained in the model at P < 0.001. Conclusions: We observed a significant positive relationship between plasma adiponectin and age, even after adjustment for visceral adiposity. These associations suggest that adiponectin concentrations are affected by visceral adiposity, with additional independent effects of age.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalClinica Chimica Acta
Volume389
Issue number1-2
DOIs
Publication statusPublished - 2008 Mar 1

Fingerprint

Intra-Abdominal Fat
Adiponectin
Fats
Plasmas
Glucose
Adiposity
Nonesterified Fatty Acids
Interleukin-6
Age Groups
Insulin
Abdominal Fat
Blood Urea Nitrogen
Age Distribution
Waist Circumference
Tomography
Urea
Adipose Tissue
Blood
Nitrogen

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Koh, Soo Jeong ; Hyun, Yae Jung ; Choi, So Yeon ; Chae, Jey Sook ; Kim, Ji Young ; Park, Sungha ; Ahn, Chul Min ; Jang, Yangsoo ; Lee, Jong Ho. / Influence of age and visceral fat area on plasma adiponectin concentrations in women with normal glucose tolerance. In: Clinica Chimica Acta. 2008 ; Vol. 389, No. 1-2. pp. 45-50.
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Influence of age and visceral fat area on plasma adiponectin concentrations in women with normal glucose tolerance. / Koh, Soo Jeong; Hyun, Yae Jung; Choi, So Yeon; Chae, Jey Sook; Kim, Ji Young; Park, Sungha; Ahn, Chul Min; Jang, Yangsoo; Lee, Jong Ho.

In: Clinica Chimica Acta, Vol. 389, No. 1-2, 01.03.2008, p. 45-50.

Research output: Contribution to journalArticle

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T1 - Influence of age and visceral fat area on plasma adiponectin concentrations in women with normal glucose tolerance

AU - Koh, Soo Jeong

AU - Hyun, Yae Jung

AU - Choi, So Yeon

AU - Chae, Jey Sook

AU - Kim, Ji Young

AU - Park, Sungha

AU - Ahn, Chul Min

AU - Jang, Yangsoo

AU - Lee, Jong Ho

PY - 2008/3/1

Y1 - 2008/3/1

N2 - Background: Age-related adiponectin concentration has been discrepantly reported. We investigated the distribution of adiponectin by age in healthy women with normal glucose tolerance (NGT) and the relationship of adiponectin with visceral fat area (VFA). Methods: Three-hundred fifty-nine women (age: 38 ± 0.6 years, BMI: 26.5 ± 0.2 kg/m2) were categorized into 4 age-groups: 20-29, 30-39, 40-49, and 50-64 years. Computed tomography was performed to measure abdominal fat area and adiponectin, TNF-α, interleukin-6 (IL-6), CRP, insulin, free fatty acid (FFA), and blood urea nitrogen (BUN) were determined. Results: No significant differences were observed in BMI, total body fat percent and concentrations of insulin, IL-6 and CRP among age-groups. Waist circumference, total fat area at L4, and FFA were significantly higher only in postmenopausal women than in previous decades of premenopausal women. VFA, adiponectin and TNF-α concentrations are significantly higher in older women than in younger women. Higher adiponectin concentration in older women was clearly shown even after adjustment for VFA (P < 0.05). Age per se was positively correlated with plasma adiponectin concentrations (r = 0.21, P < 0.001) and these relationship became stronger (r = 0.36, P < 0.001) after controlled for VFA. VFA was negatively correlated with adiponectin (r = - 0.16, P < 0.01) in total studied population. However, when analyzed subgroups separately, a strong negative correlation (r = - 0.37, P < 0.001) was found in younger women (< 40 years), while a weak significant relationship (r = - 0.18, P < 0.05) was found in older women (≥ 40 years). In a multiple stepwise regression model to predict adiponectin, only age and VFA remained in the model at P < 0.001. Conclusions: We observed a significant positive relationship between plasma adiponectin and age, even after adjustment for visceral adiposity. These associations suggest that adiponectin concentrations are affected by visceral adiposity, with additional independent effects of age.

AB - Background: Age-related adiponectin concentration has been discrepantly reported. We investigated the distribution of adiponectin by age in healthy women with normal glucose tolerance (NGT) and the relationship of adiponectin with visceral fat area (VFA). Methods: Three-hundred fifty-nine women (age: 38 ± 0.6 years, BMI: 26.5 ± 0.2 kg/m2) were categorized into 4 age-groups: 20-29, 30-39, 40-49, and 50-64 years. Computed tomography was performed to measure abdominal fat area and adiponectin, TNF-α, interleukin-6 (IL-6), CRP, insulin, free fatty acid (FFA), and blood urea nitrogen (BUN) were determined. Results: No significant differences were observed in BMI, total body fat percent and concentrations of insulin, IL-6 and CRP among age-groups. Waist circumference, total fat area at L4, and FFA were significantly higher only in postmenopausal women than in previous decades of premenopausal women. VFA, adiponectin and TNF-α concentrations are significantly higher in older women than in younger women. Higher adiponectin concentration in older women was clearly shown even after adjustment for VFA (P < 0.05). Age per se was positively correlated with plasma adiponectin concentrations (r = 0.21, P < 0.001) and these relationship became stronger (r = 0.36, P < 0.001) after controlled for VFA. VFA was negatively correlated with adiponectin (r = - 0.16, P < 0.01) in total studied population. However, when analyzed subgroups separately, a strong negative correlation (r = - 0.37, P < 0.001) was found in younger women (< 40 years), while a weak significant relationship (r = - 0.18, P < 0.05) was found in older women (≥ 40 years). In a multiple stepwise regression model to predict adiponectin, only age and VFA remained in the model at P < 0.001. Conclusions: We observed a significant positive relationship between plasma adiponectin and age, even after adjustment for visceral adiposity. These associations suggest that adiponectin concentrations are affected by visceral adiposity, with additional independent effects of age.

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