Abstract
The aim of the present study is to analyze the generation of osteoporotic vertebral bone induced by lack of calcium during growth period and analyze its effects for disc degeneration, based on biomechanical and histomorphometrical study. Mechanical and histomorphological characteristics of lumbar vertebral bones and discs of rats with calcium free diet (CFD) were detected and tracked by using high resolution in-vivo micro-computed tomography (in-vivo micro-CT), finite element (FE) and histological analysis. Twenty female Sprague-Dawley rats (6 weeks old, approximate weight 170g) were randomly divided into two groups (CFD group: 10, NOR group: 10). The CFD group was maintained on a refined calcium-controlled semisynthetic diet without added calcium, to induce osteoporosis. All lumbar (L1-L6) were scanned by using in vivo micro-CT with 35μm resolution at 0, 4, 8 weeks to track the effects of CFD on the generation of osteoporosis. The findings of the present study indicated that calcium insufficiency was the main factor in the generation of osteoporosis and it induced lumbar vertebral disc degeneration. This study is a valuable experiment to firstly evaluate osteoporotic vertebral bone and disc degeneration induced by lack of calcium during growth period from a biomechanical and histomorphometrical point of view.
| Original language | English |
|---|---|
| Pages (from-to) | 251-253 |
| Number of pages | 3 |
| Journal | World Academy of Science, Engineering and Technology |
| Volume | 58 |
| Publication status | Published - 2009 Oct 1 |
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All Science Journal Classification (ASJC) codes
- Engineering(all)
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Influence of calcium intake level to osteoporotic vertebral bone and degenerated disc in biomechanical study. / Woo, Dae Gon; Park, Ji Hyung; Kim, Chi Hoon; Lee, Tae Woo; Lee, Beob Yi; Kim, Hansung.
In: World Academy of Science, Engineering and Technology, Vol. 58, 01.10.2009, p. 251-253.Research output: Contribution to journal › Article
TY - JOUR
T1 - Influence of calcium intake level to osteoporotic vertebral bone and degenerated disc in biomechanical study
AU - Woo, Dae Gon
AU - Park, Ji Hyung
AU - Kim, Chi Hoon
AU - Lee, Tae Woo
AU - Lee, Beob Yi
AU - Kim, Hansung
PY - 2009/10/1
Y1 - 2009/10/1
N2 - The aim of the present study is to analyze the generation of osteoporotic vertebral bone induced by lack of calcium during growth period and analyze its effects for disc degeneration, based on biomechanical and histomorphometrical study. Mechanical and histomorphological characteristics of lumbar vertebral bones and discs of rats with calcium free diet (CFD) were detected and tracked by using high resolution in-vivo micro-computed tomography (in-vivo micro-CT), finite element (FE) and histological analysis. Twenty female Sprague-Dawley rats (6 weeks old, approximate weight 170g) were randomly divided into two groups (CFD group: 10, NOR group: 10). The CFD group was maintained on a refined calcium-controlled semisynthetic diet without added calcium, to induce osteoporosis. All lumbar (L1-L6) were scanned by using in vivo micro-CT with 35μm resolution at 0, 4, 8 weeks to track the effects of CFD on the generation of osteoporosis. The findings of the present study indicated that calcium insufficiency was the main factor in the generation of osteoporosis and it induced lumbar vertebral disc degeneration. This study is a valuable experiment to firstly evaluate osteoporotic vertebral bone and disc degeneration induced by lack of calcium during growth period from a biomechanical and histomorphometrical point of view.
AB - The aim of the present study is to analyze the generation of osteoporotic vertebral bone induced by lack of calcium during growth period and analyze its effects for disc degeneration, based on biomechanical and histomorphometrical study. Mechanical and histomorphological characteristics of lumbar vertebral bones and discs of rats with calcium free diet (CFD) were detected and tracked by using high resolution in-vivo micro-computed tomography (in-vivo micro-CT), finite element (FE) and histological analysis. Twenty female Sprague-Dawley rats (6 weeks old, approximate weight 170g) were randomly divided into two groups (CFD group: 10, NOR group: 10). The CFD group was maintained on a refined calcium-controlled semisynthetic diet without added calcium, to induce osteoporosis. All lumbar (L1-L6) were scanned by using in vivo micro-CT with 35μm resolution at 0, 4, 8 weeks to track the effects of CFD on the generation of osteoporosis. The findings of the present study indicated that calcium insufficiency was the main factor in the generation of osteoporosis and it induced lumbar vertebral disc degeneration. This study is a valuable experiment to firstly evaluate osteoporotic vertebral bone and disc degeneration induced by lack of calcium during growth period from a biomechanical and histomorphometrical point of view.
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M3 - Article
VL - 58
SP - 251
EP - 253
JO - World Academy of Science, Engineering and Technology
JF - World Academy of Science, Engineering and Technology
SN - 2010-376X
ER -