Influence of calcium intake level to osteoporotic vertebral bone and degenerated disc in biomechanical study

Dae Gon Woo, Ji Hyung Park, Chi Hoon Kim, Tae Woo Lee, Beob Yi Lee, Hansung Kim

Research output: Contribution to journalArticle

Abstract

The aim of the present study is to analyze the generation of osteoporotic vertebral bone induced by lack of calcium during growth period and analyze its effects for disc degeneration, based on biomechanical and histomorphometrical study. Mechanical and histomorphological characteristics of lumbar vertebral bones and discs of rats with calcium free diet (CFD) were detected and tracked by using high resolution in-vivo micro-computed tomography (in-vivo micro-CT), finite element (FE) and histological analysis. Twenty female Sprague-Dawley rats (6 weeks old, approximate weight 170g) were randomly divided into two groups (CFD group: 10, NOR group: 10). The CFD group was maintained on a refined calcium-controlled semisynthetic diet without added calcium, to induce osteoporosis. All lumbar (L1-L6) were scanned by using in vivo micro-CT with 35μm resolution at 0, 4, 8 weeks to track the effects of CFD on the generation of osteoporosis. The findings of the present study indicated that calcium insufficiency was the main factor in the generation of osteoporosis and it induced lumbar vertebral disc degeneration. This study is a valuable experiment to firstly evaluate osteoporotic vertebral bone and disc degeneration induced by lack of calcium during growth period from a biomechanical and histomorphometrical point of view.

Original languageEnglish
Pages (from-to)251-253
Number of pages3
JournalWorld Academy of Science, Engineering and Technology
Volume58
Publication statusPublished - 2009 Oct 1

Fingerprint

Calcium
Bone
Nutrition
Rats
Tomography

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

@article{c1ac8a20560d4264a86b2c83ed99a8e5,
title = "Influence of calcium intake level to osteoporotic vertebral bone and degenerated disc in biomechanical study",
abstract = "The aim of the present study is to analyze the generation of osteoporotic vertebral bone induced by lack of calcium during growth period and analyze its effects for disc degeneration, based on biomechanical and histomorphometrical study. Mechanical and histomorphological characteristics of lumbar vertebral bones and discs of rats with calcium free diet (CFD) were detected and tracked by using high resolution in-vivo micro-computed tomography (in-vivo micro-CT), finite element (FE) and histological analysis. Twenty female Sprague-Dawley rats (6 weeks old, approximate weight 170g) were randomly divided into two groups (CFD group: 10, NOR group: 10). The CFD group was maintained on a refined calcium-controlled semisynthetic diet without added calcium, to induce osteoporosis. All lumbar (L1-L6) were scanned by using in vivo micro-CT with 35μm resolution at 0, 4, 8 weeks to track the effects of CFD on the generation of osteoporosis. The findings of the present study indicated that calcium insufficiency was the main factor in the generation of osteoporosis and it induced lumbar vertebral disc degeneration. This study is a valuable experiment to firstly evaluate osteoporotic vertebral bone and disc degeneration induced by lack of calcium during growth period from a biomechanical and histomorphometrical point of view.",
author = "Woo, {Dae Gon} and Park, {Ji Hyung} and Kim, {Chi Hoon} and Lee, {Tae Woo} and Lee, {Beob Yi} and Hansung Kim",
year = "2009",
month = "10",
day = "1",
language = "English",
volume = "58",
pages = "251--253",
journal = "World Academy of Science, Engineering and Technology",
issn = "2010-376X",
publisher = "World Academy of Science Engineering and Technology",

}

Influence of calcium intake level to osteoporotic vertebral bone and degenerated disc in biomechanical study. / Woo, Dae Gon; Park, Ji Hyung; Kim, Chi Hoon; Lee, Tae Woo; Lee, Beob Yi; Kim, Hansung.

In: World Academy of Science, Engineering and Technology, Vol. 58, 01.10.2009, p. 251-253.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Influence of calcium intake level to osteoporotic vertebral bone and degenerated disc in biomechanical study

AU - Woo, Dae Gon

AU - Park, Ji Hyung

AU - Kim, Chi Hoon

AU - Lee, Tae Woo

AU - Lee, Beob Yi

AU - Kim, Hansung

PY - 2009/10/1

Y1 - 2009/10/1

N2 - The aim of the present study is to analyze the generation of osteoporotic vertebral bone induced by lack of calcium during growth period and analyze its effects for disc degeneration, based on biomechanical and histomorphometrical study. Mechanical and histomorphological characteristics of lumbar vertebral bones and discs of rats with calcium free diet (CFD) were detected and tracked by using high resolution in-vivo micro-computed tomography (in-vivo micro-CT), finite element (FE) and histological analysis. Twenty female Sprague-Dawley rats (6 weeks old, approximate weight 170g) were randomly divided into two groups (CFD group: 10, NOR group: 10). The CFD group was maintained on a refined calcium-controlled semisynthetic diet without added calcium, to induce osteoporosis. All lumbar (L1-L6) were scanned by using in vivo micro-CT with 35μm resolution at 0, 4, 8 weeks to track the effects of CFD on the generation of osteoporosis. The findings of the present study indicated that calcium insufficiency was the main factor in the generation of osteoporosis and it induced lumbar vertebral disc degeneration. This study is a valuable experiment to firstly evaluate osteoporotic vertebral bone and disc degeneration induced by lack of calcium during growth period from a biomechanical and histomorphometrical point of view.

AB - The aim of the present study is to analyze the generation of osteoporotic vertebral bone induced by lack of calcium during growth period and analyze its effects for disc degeneration, based on biomechanical and histomorphometrical study. Mechanical and histomorphological characteristics of lumbar vertebral bones and discs of rats with calcium free diet (CFD) were detected and tracked by using high resolution in-vivo micro-computed tomography (in-vivo micro-CT), finite element (FE) and histological analysis. Twenty female Sprague-Dawley rats (6 weeks old, approximate weight 170g) were randomly divided into two groups (CFD group: 10, NOR group: 10). The CFD group was maintained on a refined calcium-controlled semisynthetic diet without added calcium, to induce osteoporosis. All lumbar (L1-L6) were scanned by using in vivo micro-CT with 35μm resolution at 0, 4, 8 weeks to track the effects of CFD on the generation of osteoporosis. The findings of the present study indicated that calcium insufficiency was the main factor in the generation of osteoporosis and it induced lumbar vertebral disc degeneration. This study is a valuable experiment to firstly evaluate osteoporotic vertebral bone and disc degeneration induced by lack of calcium during growth period from a biomechanical and histomorphometrical point of view.

UR - http://www.scopus.com/inward/record.url?scp=79954486074&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79954486074&partnerID=8YFLogxK

M3 - Article

VL - 58

SP - 251

EP - 253

JO - World Academy of Science, Engineering and Technology

JF - World Academy of Science, Engineering and Technology

SN - 2010-376X

ER -