Influence of epiretinal membrane on the measurement of peripapillary retinal nerve fibre layer thickness using spectral-domain coherence tomography

Yun Ha Lee, Hyoung Won Bae, Sang Jin Seo, Sang Yeop Lee, Seok Ho Beon, Sungyong Kang, chanyun kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background/aims: To investigate the effect of epiretinal membrane (ERM) on peripapillary retinal nerve fibre layer (RNFL) thickness measurements using spectraldomain optical coherence tomography (Spectralis; Heidelberg Engineering). Methods: A total of 134 patients with idiopathic ERM and 63 healthy controls were included in this observational comparative study. We categorised ERMs into three severity grades, based on retinal appearance in macular scans. All eyes with ERM were classified into two groups; those involving the peripapillary scan area (ERM+pp, n=68 eyes) and not involving the peripapillary scan area (ERM-pp, n=66 eyes) using the macular disc scan. Peripapillary RNFL thickness was compared between related subgroups as (ERM+pp) or (ERM-pp) group. Results: Temporal peripapillary RNFL thickness was significantly greater in the ERM+pp group (109.44 ±22.91 μm), followed by the ERM-pp (82.60 ±11.77 μm, p<0.001) and control (75.42±10.49 μm, p<0.001) groups. Temporal peripapillary RNFL thickness significantly increased with ERM grade in the ERM+pp and ERM-pp groups (both p<0.001). The peripapillary RNFL thickness was overestimated (exceeded 99th percentile) in the temporal sector in 49 eyes (72.1%) in the ERM+pp group and in 5 eyes (7.6%) in the ERM-pp group. Conclusions: Temporal and global peripapillary RNFL thickness is significantly higher in eyes with ERM, especially when the ERM extends into the peripapillary area. However, some eyes with an ERM that does not involve the peripapillary scan area still show peripapillary RNFL thickening. Measured peripapillary RNFL thickness was significantly and positively correlated with ERM severity.

Original languageEnglish
Pages (from-to)1035-1040
Number of pages6
JournalBritish Journal of Ophthalmology
Volume100
Issue number8
DOIs
Publication statusPublished - 2016 Aug 1

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Epiretinal Membrane
Nerve Fibers
Tomography

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Lee, Yun Ha ; Bae, Hyoung Won ; Seo, Sang Jin ; Lee, Sang Yeop ; Beon, Seok Ho ; Kang, Sungyong ; kim, chanyun. / Influence of epiretinal membrane on the measurement of peripapillary retinal nerve fibre layer thickness using spectral-domain coherence tomography. In: British Journal of Ophthalmology. 2016 ; Vol. 100, No. 8. pp. 1035-1040.
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abstract = "Background/aims: To investigate the effect of epiretinal membrane (ERM) on peripapillary retinal nerve fibre layer (RNFL) thickness measurements using spectraldomain optical coherence tomography (Spectralis; Heidelberg Engineering). Methods: A total of 134 patients with idiopathic ERM and 63 healthy controls were included in this observational comparative study. We categorised ERMs into three severity grades, based on retinal appearance in macular scans. All eyes with ERM were classified into two groups; those involving the peripapillary scan area (ERM+pp, n=68 eyes) and not involving the peripapillary scan area (ERM-pp, n=66 eyes) using the macular disc scan. Peripapillary RNFL thickness was compared between related subgroups as (ERM+pp) or (ERM-pp) group. Results: Temporal peripapillary RNFL thickness was significantly greater in the ERM+pp group (109.44 ±22.91 μm), followed by the ERM-pp (82.60 ±11.77 μm, p<0.001) and control (75.42±10.49 μm, p<0.001) groups. Temporal peripapillary RNFL thickness significantly increased with ERM grade in the ERM+pp and ERM-pp groups (both p<0.001). The peripapillary RNFL thickness was overestimated (exceeded 99th percentile) in the temporal sector in 49 eyes (72.1{\%}) in the ERM+pp group and in 5 eyes (7.6{\%}) in the ERM-pp group. Conclusions: Temporal and global peripapillary RNFL thickness is significantly higher in eyes with ERM, especially when the ERM extends into the peripapillary area. However, some eyes with an ERM that does not involve the peripapillary scan area still show peripapillary RNFL thickening. Measured peripapillary RNFL thickness was significantly and positively correlated with ERM severity.",
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Influence of epiretinal membrane on the measurement of peripapillary retinal nerve fibre layer thickness using spectral-domain coherence tomography. / Lee, Yun Ha; Bae, Hyoung Won; Seo, Sang Jin; Lee, Sang Yeop; Beon, Seok Ho; Kang, Sungyong; kim, chanyun.

In: British Journal of Ophthalmology, Vol. 100, No. 8, 01.08.2016, p. 1035-1040.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Influence of epiretinal membrane on the measurement of peripapillary retinal nerve fibre layer thickness using spectral-domain coherence tomography

AU - Lee, Yun Ha

AU - Bae, Hyoung Won

AU - Seo, Sang Jin

AU - Lee, Sang Yeop

AU - Beon, Seok Ho

AU - Kang, Sungyong

AU - kim, chanyun

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AB - Background/aims: To investigate the effect of epiretinal membrane (ERM) on peripapillary retinal nerve fibre layer (RNFL) thickness measurements using spectraldomain optical coherence tomography (Spectralis; Heidelberg Engineering). Methods: A total of 134 patients with idiopathic ERM and 63 healthy controls were included in this observational comparative study. We categorised ERMs into three severity grades, based on retinal appearance in macular scans. All eyes with ERM were classified into two groups; those involving the peripapillary scan area (ERM+pp, n=68 eyes) and not involving the peripapillary scan area (ERM-pp, n=66 eyes) using the macular disc scan. Peripapillary RNFL thickness was compared between related subgroups as (ERM+pp) or (ERM-pp) group. Results: Temporal peripapillary RNFL thickness was significantly greater in the ERM+pp group (109.44 ±22.91 μm), followed by the ERM-pp (82.60 ±11.77 μm, p<0.001) and control (75.42±10.49 μm, p<0.001) groups. Temporal peripapillary RNFL thickness significantly increased with ERM grade in the ERM+pp and ERM-pp groups (both p<0.001). The peripapillary RNFL thickness was overestimated (exceeded 99th percentile) in the temporal sector in 49 eyes (72.1%) in the ERM+pp group and in 5 eyes (7.6%) in the ERM-pp group. Conclusions: Temporal and global peripapillary RNFL thickness is significantly higher in eyes with ERM, especially when the ERM extends into the peripapillary area. However, some eyes with an ERM that does not involve the peripapillary scan area still show peripapillary RNFL thickening. Measured peripapillary RNFL thickness was significantly and positively correlated with ERM severity.

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