Abstract
Background/aims: To investigate the effect of epiretinal membrane (ERM) on peripapillary retinal nerve fibre layer (RNFL) thickness measurements using spectraldomain optical coherence tomography (Spectralis; Heidelberg Engineering). Methods: A total of 134 patients with idiopathic ERM and 63 healthy controls were included in this observational comparative study. We categorised ERMs into three severity grades, based on retinal appearance in macular scans. All eyes with ERM were classified into two groups; those involving the peripapillary scan area (ERM+pp, n=68 eyes) and not involving the peripapillary scan area (ERM-pp, n=66 eyes) using the macular disc scan. Peripapillary RNFL thickness was compared between related subgroups as (ERM+pp) or (ERM-pp) group. Results: Temporal peripapillary RNFL thickness was significantly greater in the ERM+pp group (109.44 ±22.91 μm), followed by the ERM-pp (82.60 ±11.77 μm, p<0.001) and control (75.42±10.49 μm, p<0.001) groups. Temporal peripapillary RNFL thickness significantly increased with ERM grade in the ERM+pp and ERM-pp groups (both p<0.001). The peripapillary RNFL thickness was overestimated (exceeded 99th percentile) in the temporal sector in 49 eyes (72.1%) in the ERM+pp group and in 5 eyes (7.6%) in the ERM-pp group. Conclusions: Temporal and global peripapillary RNFL thickness is significantly higher in eyes with ERM, especially when the ERM extends into the peripapillary area. However, some eyes with an ERM that does not involve the peripapillary scan area still show peripapillary RNFL thickening. Measured peripapillary RNFL thickness was significantly and positively correlated with ERM severity.
| Original language | English |
|---|---|
| Pages (from-to) | 1035-1040 |
| Number of pages | 6 |
| Journal | British Journal of Ophthalmology |
| Volume | 100 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2016 Aug |
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All Science Journal Classification (ASJC) codes
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
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Influence of epiretinal membrane on the measurement of peripapillary retinal nerve fibre layer thickness using spectral-domain coherence tomography. / Lee, Yun Ha; Bae, Hyoung Won; Seo, Sang Jin; Lee, Sang Yeop; Beon, Seok Ho; Kang, Sungyong; Kim, Chan Yun.
In: British Journal of Ophthalmology, Vol. 100, No. 8, 08.2016, p. 1035-1040.Research output: Contribution to journal › Article
TY - JOUR
T1 - Influence of epiretinal membrane on the measurement of peripapillary retinal nerve fibre layer thickness using spectral-domain coherence tomography
AU - Lee, Yun Ha
AU - Bae, Hyoung Won
AU - Seo, Sang Jin
AU - Lee, Sang Yeop
AU - Beon, Seok Ho
AU - Kang, Sungyong
AU - Kim, Chan Yun
PY - 2016/8
Y1 - 2016/8
N2 - Background/aims: To investigate the effect of epiretinal membrane (ERM) on peripapillary retinal nerve fibre layer (RNFL) thickness measurements using spectraldomain optical coherence tomography (Spectralis; Heidelberg Engineering). Methods: A total of 134 patients with idiopathic ERM and 63 healthy controls were included in this observational comparative study. We categorised ERMs into three severity grades, based on retinal appearance in macular scans. All eyes with ERM were classified into two groups; those involving the peripapillary scan area (ERM+pp, n=68 eyes) and not involving the peripapillary scan area (ERM-pp, n=66 eyes) using the macular disc scan. Peripapillary RNFL thickness was compared between related subgroups as (ERM+pp) or (ERM-pp) group. Results: Temporal peripapillary RNFL thickness was significantly greater in the ERM+pp group (109.44 ±22.91 μm), followed by the ERM-pp (82.60 ±11.77 μm, p<0.001) and control (75.42±10.49 μm, p<0.001) groups. Temporal peripapillary RNFL thickness significantly increased with ERM grade in the ERM+pp and ERM-pp groups (both p<0.001). The peripapillary RNFL thickness was overestimated (exceeded 99th percentile) in the temporal sector in 49 eyes (72.1%) in the ERM+pp group and in 5 eyes (7.6%) in the ERM-pp group. Conclusions: Temporal and global peripapillary RNFL thickness is significantly higher in eyes with ERM, especially when the ERM extends into the peripapillary area. However, some eyes with an ERM that does not involve the peripapillary scan area still show peripapillary RNFL thickening. Measured peripapillary RNFL thickness was significantly and positively correlated with ERM severity.
AB - Background/aims: To investigate the effect of epiretinal membrane (ERM) on peripapillary retinal nerve fibre layer (RNFL) thickness measurements using spectraldomain optical coherence tomography (Spectralis; Heidelberg Engineering). Methods: A total of 134 patients with idiopathic ERM and 63 healthy controls were included in this observational comparative study. We categorised ERMs into three severity grades, based on retinal appearance in macular scans. All eyes with ERM were classified into two groups; those involving the peripapillary scan area (ERM+pp, n=68 eyes) and not involving the peripapillary scan area (ERM-pp, n=66 eyes) using the macular disc scan. Peripapillary RNFL thickness was compared between related subgroups as (ERM+pp) or (ERM-pp) group. Results: Temporal peripapillary RNFL thickness was significantly greater in the ERM+pp group (109.44 ±22.91 μm), followed by the ERM-pp (82.60 ±11.77 μm, p<0.001) and control (75.42±10.49 μm, p<0.001) groups. Temporal peripapillary RNFL thickness significantly increased with ERM grade in the ERM+pp and ERM-pp groups (both p<0.001). The peripapillary RNFL thickness was overestimated (exceeded 99th percentile) in the temporal sector in 49 eyes (72.1%) in the ERM+pp group and in 5 eyes (7.6%) in the ERM-pp group. Conclusions: Temporal and global peripapillary RNFL thickness is significantly higher in eyes with ERM, especially when the ERM extends into the peripapillary area. However, some eyes with an ERM that does not involve the peripapillary scan area still show peripapillary RNFL thickening. Measured peripapillary RNFL thickness was significantly and positively correlated with ERM severity.
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U2 - 10.1136/bjophthalmol-2015-307313
DO - 10.1136/bjophthalmol-2015-307313
M3 - Article
C2 - 26541433
AN - SCOPUS:84982798808
VL - 100
SP - 1035
EP - 1040
JO - British Journal of Ophthalmology
JF - British Journal of Ophthalmology
SN - 0007-1161
IS - 8
ER -