Influence of estrogen-related receptor γ (ESRRG) rs1890552 A > G polymorphism on changes in fasting glucose and arterial stiffness

Minjoo Kim; Hye Jin Yoo; Minkyung Kim; Haengok Seo; Jey Sook Chae; Sang Hyun Lee; Jong Ho Lee

doi:10.1038/s41598-017-10192-6

Influence of estrogen-related receptor γ (ESRRG) rs1890552 A > G polymorphism on changes in fasting glucose and arterial stiffness

Minjoo Kim, Hye Jin Yoo, Minkyung Kim, Haengok Seo, Jey Sook Chae, Sang Hyun Lee, Jong Ho Lee

Department of Food and Nutrition

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

To determine the effects of the estrogen-related receptor γ (ESRRG) rs1890552 A > G polymorphism on dietary advice-mediated changes in fasting glucose and arterial stiffness, 374 subjects with normal fasting glucose (NFG; control group, no treatment) and 142 subjects with impaired fasting glucose (IFG group, dietary advice) were followed for 3.5 years. At follow-up, the GG subjects in the IFG group showed a significant reduction in fasting glucose, which was greater than in the AA subjects. A significant association was observed between ESRRG rs1890552 A > G polymorphism and changes in fasting glucose, brachial-ankle pulse wave velocity (ba-PWV), and 8-epi-prostaglandin F_2α in the IFG subjects. At baseline, the GG subjects showed a higher ba-PWV than the AA subjects in the IFG group. At the 3.5-year follow-up, subjects with AA or AG showed significant increases in ba-PWV, whereas subjects with GG showed a decrease from baseline. This study suggests that the ESRRG rs1890552 A > G polymorphism may modulate interindividual differences in atrial stiffness, with a reduction in fasting glucose in response to dietary advice in subjects with IFG after a 3.5-year follow-up.

Original language	English
Article number	9787
Journal	Scientific reports
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s41598-017-10192-6
Publication status	Published - 2017 Dec 1

Bibliographical note

Funding Information:
The genotype data were produced using a Korean Chip (K-CHIP) available from the K-CHIP consortium. The K-CHIP was designed by the Center for Genome Science at the Korea National Institute of Health, Korea (4845-301, 3000-3031). This study was funded by the Bio-Synergy Research Project (NRF-2012M3A9C4048762) and the Mid-Career Researcher Program (NRF-2016R1A2B4011662) of the Ministry of Science, ICT and Future Planning through the National Research Foundation, Republic of Korea.

Funding Information:
The genotype data were produced using a Korean Chip (K-CHIP) available from the K-CHIP consortium. The K-CHIP was designed by the Center for Genome Science at the Korea National Institute of Health, Korea (4845– 301, 3000–3031). This study was funded by the Bio-Synergy Research Project (NRF-2012M3A9C4048762) and the Mid-Career Researcher Program (NRF-2016R1A2B4011662) of the Ministry of Science, ICT and Future Planning through the National Research Foundation, Republic of Korea.

Publisher Copyright:
© 2017 The Author(s).

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10.1038/s41598-017-10192-6

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title = "Influence of estrogen-related receptor γ (ESRRG) rs1890552 A > G polymorphism on changes in fasting glucose and arterial stiffness",

abstract = "To determine the effects of the estrogen-related receptor γ (ESRRG) rs1890552 A > G polymorphism on dietary advice-mediated changes in fasting glucose and arterial stiffness, 374 subjects with normal fasting glucose (NFG; control group, no treatment) and 142 subjects with impaired fasting glucose (IFG group, dietary advice) were followed for 3.5 years. At follow-up, the GG subjects in the IFG group showed a significant reduction in fasting glucose, which was greater than in the AA subjects. A significant association was observed between ESRRG rs1890552 A > G polymorphism and changes in fasting glucose, brachial-ankle pulse wave velocity (ba-PWV), and 8-epi-prostaglandin F2α in the IFG subjects. At baseline, the GG subjects showed a higher ba-PWV than the AA subjects in the IFG group. At the 3.5-year follow-up, subjects with AA or AG showed significant increases in ba-PWV, whereas subjects with GG showed a decrease from baseline. This study suggests that the ESRRG rs1890552 A > G polymorphism may modulate interindividual differences in atrial stiffness, with a reduction in fasting glucose in response to dietary advice in subjects with IFG after a 3.5-year follow-up.",

author = "Minjoo Kim and Yoo, {Hye Jin} and Minkyung Kim and Haengok Seo and Chae, {Jey Sook} and Lee, {Sang Hyun} and Lee, {Jong Ho}",

note = "Funding Information: The genotype data were produced using a Korean Chip (K-CHIP) available from the K-CHIP consortium. The K-CHIP was designed by the Center for Genome Science at the Korea National Institute of Health, Korea (4845-301, 3000-3031). This study was funded by the Bio-Synergy Research Project (NRF-2012M3A9C4048762) and the Mid-Career Researcher Program (NRF-2016R1A2B4011662) of the Ministry of Science, ICT and Future Planning through the National Research Foundation, Republic of Korea. Funding Information: The genotype data were produced using a Korean Chip (K-CHIP) available from the K-CHIP consortium. The K-CHIP was designed by the Center for Genome Science at the Korea National Institute of Health, Korea (4845– 301, 3000–3031). This study was funded by the Bio-Synergy Research Project (NRF-2012M3A9C4048762) and the Mid-Career Researcher Program (NRF-2016R1A2B4011662) of the Ministry of Science, ICT and Future Planning through the National Research Foundation, Republic of Korea. Publisher Copyright: {\textcopyright} 2017 The Author(s).",

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AU - Kim, Minjoo

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AU - Kim, Minkyung

AU - Seo, Haengok

AU - Chae, Jey Sook

AU - Lee, Sang Hyun

AU - Lee, Jong Ho

N1 - Funding Information: The genotype data were produced using a Korean Chip (K-CHIP) available from the K-CHIP consortium. The K-CHIP was designed by the Center for Genome Science at the Korea National Institute of Health, Korea (4845-301, 3000-3031). This study was funded by the Bio-Synergy Research Project (NRF-2012M3A9C4048762) and the Mid-Career Researcher Program (NRF-2016R1A2B4011662) of the Ministry of Science, ICT and Future Planning through the National Research Foundation, Republic of Korea. Funding Information: The genotype data were produced using a Korean Chip (K-CHIP) available from the K-CHIP consortium. The K-CHIP was designed by the Center for Genome Science at the Korea National Institute of Health, Korea (4845– 301, 3000–3031). This study was funded by the Bio-Synergy Research Project (NRF-2012M3A9C4048762) and the Mid-Career Researcher Program (NRF-2016R1A2B4011662) of the Ministry of Science, ICT and Future Planning through the National Research Foundation, Republic of Korea. Publisher Copyright: © 2017 The Author(s).

PY - 2017/12/1

Y1 - 2017/12/1

N2 - To determine the effects of the estrogen-related receptor γ (ESRRG) rs1890552 A > G polymorphism on dietary advice-mediated changes in fasting glucose and arterial stiffness, 374 subjects with normal fasting glucose (NFG; control group, no treatment) and 142 subjects with impaired fasting glucose (IFG group, dietary advice) were followed for 3.5 years. At follow-up, the GG subjects in the IFG group showed a significant reduction in fasting glucose, which was greater than in the AA subjects. A significant association was observed between ESRRG rs1890552 A > G polymorphism and changes in fasting glucose, brachial-ankle pulse wave velocity (ba-PWV), and 8-epi-prostaglandin F2α in the IFG subjects. At baseline, the GG subjects showed a higher ba-PWV than the AA subjects in the IFG group. At the 3.5-year follow-up, subjects with AA or AG showed significant increases in ba-PWV, whereas subjects with GG showed a decrease from baseline. This study suggests that the ESRRG rs1890552 A > G polymorphism may modulate interindividual differences in atrial stiffness, with a reduction in fasting glucose in response to dietary advice in subjects with IFG after a 3.5-year follow-up.

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Influence of estrogen-related receptor γ (ESRRG) rs1890552 A > G polymorphism on changes in fasting glucose and arterial stiffness

Abstract

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