Influence of quercetin-rich onion peel extracts on adipokine expression in the visceral adipose tissue of rats

Oh Yoen Kim, Seung Min Lee, Hyunju Do, Jiyoung Moon, Kyung Hea Lee, Yong Jun Cha, Min Jeong Shin

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

We examined the effects of quercetin-rich onion peel extract supplementation on adipokine expressions from adipose tissues in a diet-induced obese animal model. Male Sprague-Dawley rats (n = 24) were randomly assigned into control (n = 8), high fat diet (HF, n = 8) and high fat diet with onion peel extract (HFOE, n = 8). After 8 weeks, serum biochemical parameters, weights of adipose tissues (epididymal, perirenal and mesenteric fats) and adipokine mRNA levels (adiponectin, IL (interleukin)-6 and visfatin) along with PPAR (peroxisome proliferator-activated receptor) γ2 from adipose tissues were measured. After the 8 week supplementation, mesenteric fat weights were lower in the HFOE group than the HF group (p<0.05). Adiponectin mRNA levels (mesenteric fats) were remarkably higher in the HFOE group than the other groups (p<0.05 for both). Levels of PPARγ2 mRNA (mesenteric fats) were significantly higher in the HF group (p<0.05) than those in the control group, but those in the HFOE group were not different from those in the control group. The IL-6 mRNA levels (perirenal and mesenteric fats) were higher in the HF and HFOE groups, but those in the HFOE group were slightly lower than those in the HF group. In conclusion, quercetin-rich onion peel extract supplementation influenced adipokine expressions, particularly from mesenteric fat, addressing the modulatory effect of this substance on obesity-induced inflammation.

Original languageEnglish
Pages (from-to)432-437
Number of pages6
JournalPhytotherapy Research
Volume26
Issue number3
DOIs
Publication statusPublished - 2012 Mar 1

Fingerprint

Adipokines
Onions
Intra-Abdominal Fat
Quercetin
Fats
Adipose Tissue
Messenger RNA
Adiponectin
High Fat Diet
Interleukin-6
Nicotinamide Phosphoribosyltransferase
Weights and Measures
Control Groups
Peroxisome Proliferator-Activated Receptors
Sprague Dawley Rats
Animal Models
Obesity
Diet
Inflammation
Serum

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Kim, Oh Yoen ; Lee, Seung Min ; Do, Hyunju ; Moon, Jiyoung ; Lee, Kyung Hea ; Cha, Yong Jun ; Shin, Min Jeong. / Influence of quercetin-rich onion peel extracts on adipokine expression in the visceral adipose tissue of rats. In: Phytotherapy Research. 2012 ; Vol. 26, No. 3. pp. 432-437.
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Influence of quercetin-rich onion peel extracts on adipokine expression in the visceral adipose tissue of rats. / Kim, Oh Yoen; Lee, Seung Min; Do, Hyunju; Moon, Jiyoung; Lee, Kyung Hea; Cha, Yong Jun; Shin, Min Jeong.

In: Phytotherapy Research, Vol. 26, No. 3, 01.03.2012, p. 432-437.

Research output: Contribution to journalArticle

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