Influence of water soluble additives and HPMCP on drug release from surelease®-coated pellets containing tamsulosin hydrochloride

Min Soo Kim, Jeong Soo Kim, Sun Ho Kang, Yeon Hee Yoo, Sibeum Lee, Jeong Sook Park, Jong Soo Woo, Sung Joo Hwang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The objective of this study was to investigate the influence of various water-soluble additives and HPMCP as an enteric polymer into Surelease® for the developement of oral controlled release system containg tamsulosin hydrochloride. The drug loaded pellets were coated with only Surelease® or Surelease® containing HPMC, PEG 4000, mannitol and HPMCP (20% w/w). In case of HPMC and PEG 4000 as additives into Surelease® film, the rapid drug release was observed in pH 1.2 while the higher drug release was achieved by adding HPMCP into Surelease® as well as by increasing the amount of HPMCP (10, 20, and 30% w/w) in pH 7.2. The incorporation of HPMCP into Surelease® showed pH-denpendent drug release due to its pH-dependent nature. Therefore, the incorporation of HPMCP into Surelease® based on aqueous coating formulation is an effective way to develop oral controlled release delivery systems containing tamsulosin hydrochloride.

Original languageEnglish
Pages (from-to)1008-1013
Number of pages6
JournalArchives of pharmacal research
Volume30
Issue number8
DOIs
Publication statusPublished - 2007 Aug 31

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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