Influences of Thiopurine Methyltransferase Genotype and Activity on Thiopurine-induced Leukopenia in Korean Patients With Inflammatory Bowel Disease:A Retrospective Cohort Study

Jae Hak Kim, JaeHee Cheon, Seong Soo Hong, Chang Soo Eun, Jeong Sik Byeon, Sung Yi Hong, Bo Young Kim, Soon ho Kwon, Seung Won Kim, Dong Soo Han, Suk Kyun Yang, Won Ho Kim

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Myelotoxicity has been shown to be very common in Korean patients with inflammatory bowel disease (IBD) during azathioprine (AZA) or 6-mercaptopurine (6-MP) treatment. The purpose of this study was to investigate the relative risk of the thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) genotypes and TPMT activity for the development of leukopenia in Korean IBD patients during AZA/6-MP treatment.

Original languageEnglish
Pages (from-to)e242-e248
JournalJournal of Clinical Gastroenterology
Volume44
Issue number10
DOIs
Publication statusPublished - 2010 Jan 1

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thiopurine methyltransferase
6-Mercaptopurine
Azathioprine
Leukopenia
Inflammatory Bowel Diseases
Cohort Studies
Retrospective Studies
Genotype
Pyrophosphatases
Inosine Triphosphate
Therapeutics

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Kim, Jae Hak ; Cheon, JaeHee ; Hong, Seong Soo ; Eun, Chang Soo ; Byeon, Jeong Sik ; Hong, Sung Yi ; Kim, Bo Young ; Kwon, Soon ho ; Kim, Seung Won ; Han, Dong Soo ; Yang, Suk Kyun ; Kim, Won Ho. / Influences of Thiopurine Methyltransferase Genotype and Activity on Thiopurine-induced Leukopenia in Korean Patients With Inflammatory Bowel Disease:A Retrospective Cohort Study. In: Journal of Clinical Gastroenterology. 2010 ; Vol. 44, No. 10. pp. e242-e248.
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abstract = "Myelotoxicity has been shown to be very common in Korean patients with inflammatory bowel disease (IBD) during azathioprine (AZA) or 6-mercaptopurine (6-MP) treatment. The purpose of this study was to investigate the relative risk of the thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) genotypes and TPMT activity for the development of leukopenia in Korean IBD patients during AZA/6-MP treatment.",
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Influences of Thiopurine Methyltransferase Genotype and Activity on Thiopurine-induced Leukopenia in Korean Patients With Inflammatory Bowel Disease:A Retrospective Cohort Study. / Kim, Jae Hak; Cheon, JaeHee; Hong, Seong Soo; Eun, Chang Soo; Byeon, Jeong Sik; Hong, Sung Yi; Kim, Bo Young; Kwon, Soon ho; Kim, Seung Won; Han, Dong Soo; Yang, Suk Kyun; Kim, Won Ho.

In: Journal of Clinical Gastroenterology, Vol. 44, No. 10, 01.01.2010, p. e242-e248.

Research output: Contribution to journalArticle

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AU - Cheon, JaeHee

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AU - Hong, Sung Yi

AU - Kim, Bo Young

AU - Kwon, Soon ho

AU - Kim, Seung Won

AU - Han, Dong Soo

AU - Yang, Suk Kyun

AU - Kim, Won Ho

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