Influences of Thiopurine Methyltransferase Genotype and Activity on Thiopurine-induced Leukopenia in Korean Patients With Inflammatory Bowel Disease:A Retrospective Cohort Study

Jae Hak Kim, Jae Hee Cheon, Seong Soo Hong, Chang Soo Eun, Jeong Sik Byeon, Sung Yi Hong, Bo Young Kim, Soon ho Kwon, Seung Won Kim, Dong Soo Han, Suk Kyun Yang, Won Ho Kim

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57 Citations (Scopus)

Abstract

Myelotoxicity has been shown to be very common in Korean patients with inflammatory bowel disease (IBD) during azathioprine (AZA) or 6-mercaptopurine (6-MP) treatment. The purpose of this study was to investigate the relative risk of the thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) genotypes and TPMT activity for the development of leukopenia in Korean IBD patients during AZA/6-MP treatment.

Original languageEnglish
Pages (from-to)e242-e248
JournalJournal of Clinical Gastroenterology
Volume44
Issue number10
DOIs
Publication statusPublished - 2010 Jan 1

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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