Influencing the influenza virus: Genetic analysis and engineering of the negative-sense RNA genome

B. L. Seong

Influencing the influenza virus: Genetic analysis and engineering of the negative-sense RNA genome

Research output: Contribution to journal › Review article › peer-review

Abstract

The genome of influenza virus has become amenable to genetic analysis as a result of newly developed methods for reconstitution of the ribonucleoprotein (RNP) complex. This allows a dissection of the regulatory signals and promoters required for transcription and replication of the viral genome. The ability to rescue chimeric viruses in vivo after transfection opens up a way to engineer viruses suitable for human immunization and carrying desirable antigenic determinants.

Original language	English
Pages (from-to)	17-24
Number of pages	8
Journal	Infectious Agents and Disease
Volume	2
Issue number	1
Publication status	Published - 1993

All Science Journal Classification (ASJC) codes

Microbiology (medical)

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abstract = "The genome of influenza virus has become amenable to genetic analysis as a result of newly developed methods for reconstitution of the ribonucleoprotein (RNP) complex. This allows a dissection of the regulatory signals and promoters required for transcription and replication of the viral genome. The ability to rescue chimeric viruses in vivo after transfection opens up a way to engineer viruses suitable for human immunization and carrying desirable antigenic determinants.",

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