Abstract
The genome of influenza virus has become amenable to genetic analysis as a result of newly developed methods for reconstitution of the ribonucleoprotein (RNP) complex. This allows a dissection of the regulatory signals and promoters required for transcription and replication of the viral genome. The ability to rescue chimeric viruses in vivo after transfection opens up a way to engineer viruses suitable for human immunization and carrying desirable antigenic determinants.
| Original language | English |
|---|---|
| Pages (from-to) | 17-24 |
| Number of pages | 8 |
| Journal | Infectious Agents and Disease |
| Volume | 2 |
| Issue number | 1 |
| Publication status | Published - 1993 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Microbiology (medical)
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Influencing the influenza virus : Genetic analysis and engineering of the negative-sense RNA genome. / Seong, B. L.
In: Infectious Agents and Disease, Vol. 2, No. 1, 01.01.1993, p. 17-24.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Influencing the influenza virus
T2 - Genetic analysis and engineering of the negative-sense RNA genome
AU - Seong, B. L.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - The genome of influenza virus has become amenable to genetic analysis as a result of newly developed methods for reconstitution of the ribonucleoprotein (RNP) complex. This allows a dissection of the regulatory signals and promoters required for transcription and replication of the viral genome. The ability to rescue chimeric viruses in vivo after transfection opens up a way to engineer viruses suitable for human immunization and carrying desirable antigenic determinants.
AB - The genome of influenza virus has become amenable to genetic analysis as a result of newly developed methods for reconstitution of the ribonucleoprotein (RNP) complex. This allows a dissection of the regulatory signals and promoters required for transcription and replication of the viral genome. The ability to rescue chimeric viruses in vivo after transfection opens up a way to engineer viruses suitable for human immunization and carrying desirable antigenic determinants.
UR - http://www.scopus.com/inward/record.url?scp=0027480497&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027480497&partnerID=8YFLogxK
M3 - Review article
C2 - 8162350
AN - SCOPUS:0027480497
VL - 2
SP - 17
EP - 24
JO - Infectious Agents and Disease
JF - Infectious Agents and Disease
SN - 1056-2044
IS - 1
ER -