Influencing the influenza virus

Genetic analysis and engineering of the negative-sense RNA genome

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

The genome of influenza virus has become amenable to genetic analysis as a result of newly developed methods for reconstitution of the ribonucleoprotein (RNP) complex. This allows a dissection of the regulatory signals and promoters required for transcription and replication of the viral genome. The ability to rescue chimeric viruses in vivo after transfection opens up a way to engineer viruses suitable for human immunization and carrying desirable antigenic determinants.

Original languageEnglish
Pages (from-to)17-24
Number of pages8
JournalInfectious Agents and Disease
Volume2
Issue number1
Publication statusPublished - 1993 Jan 1

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Genetic Engineering
Orthomyxoviridae
Genome
RNA
Viruses
Ribonucleoproteins
Viral Genome
Transfection
Dissection
Epitopes
Immunization

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)

Cite this

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abstract = "The genome of influenza virus has become amenable to genetic analysis as a result of newly developed methods for reconstitution of the ribonucleoprotein (RNP) complex. This allows a dissection of the regulatory signals and promoters required for transcription and replication of the viral genome. The ability to rescue chimeric viruses in vivo after transfection opens up a way to engineer viruses suitable for human immunization and carrying desirable antigenic determinants.",
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Influencing the influenza virus : Genetic analysis and engineering of the negative-sense RNA genome. / Seong, B. L.

In: Infectious Agents and Disease, Vol. 2, No. 1, 01.01.1993, p. 17-24.

Research output: Contribution to journalReview article

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