Influencing the influenza virus: Genetic analysis and engineering of the negative-sense RNA genome

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The genome of influenza virus has become amenable to genetic analysis as a result of newly developed methods for reconstitution of the ribonucleoprotein (RNP) complex. This allows a dissection of the regulatory signals and promoters required for transcription and replication of the viral genome. The ability to rescue chimeric viruses in vivo after transfection opens up a way to engineer viruses suitable for human immunization and carrying desirable antigenic determinants.

Original languageEnglish
Pages (from-to)17-24
Number of pages8
JournalInfectious Agents and Disease
Issue number1
Publication statusPublished - 1993 Jan 1


All Science Journal Classification (ASJC) codes

  • Microbiology (medical)

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