Influenza A (H1N1) neuraminidase inhibitors from Vitis amurensis

Thi Ngoc Anh Nguyen, Trong Tuan Dao, Bui Thanh Tung, Hwanwon Choi, Eunhee Kim, Junsoo Park, Seong I.L. Lim, Won Keun Oh

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Recently, a novel H1N1 influenza A virus (H1N1/09 virus) was identified and considered a strong candidate for a novel influenza pandemic. As part of an ongoing anti-influenza screening programme on natural products, eight oligostilbenes were isolated as active principles from the methanol extract of Vitis amurensis. This manuscript reports the isolation, structural elucidation, and anti-viral activities of eight compounds on various neuraminidases from influenza A/PR/8/34 (H1N1), novel swine-origin influenza A (H1N1), and oseltamivir-resistant novel H1N1 (H274Y) expressed in 293T cells. The inhibition model of compounds 4, 6, and 7 which showed the strongest activity on the neuraminidases was examined. Detailed kinetic analysis indicated that they were all non-competitive. The synergistic effect of a combination of these non-competitive inhibitors with oseltamivir makes them a potential possibility for the control of influenza infections.

Original languageEnglish
Pages (from-to)437-443
Number of pages7
JournalFood Chemistry
Volume124
Issue number2
DOIs
Publication statusPublished - 2011 Jan 1

Fingerprint

Vitis amurensis
Oseltamivir
sialidase
Vitis
Neuraminidase
Viruses
influenza
Human Influenza
H1N1 Subtype Influenza A Virus
Biological Products
Methanol
Screening
Influenza A virus
Kinetics
HEK293 Cells
Pandemics
Infection Control
pandemic
Swine
methanol

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Food Science

Cite this

Nguyen, T. N. A., Dao, T. T., Tung, B. T., Choi, H., Kim, E., Park, J., ... Oh, W. K. (2011). Influenza A (H1N1) neuraminidase inhibitors from Vitis amurensis. Food Chemistry, 124(2), 437-443. https://doi.org/10.1016/j.foodchem.2010.06.049
Nguyen, Thi Ngoc Anh ; Dao, Trong Tuan ; Tung, Bui Thanh ; Choi, Hwanwon ; Kim, Eunhee ; Park, Junsoo ; Lim, Seong I.L. ; Oh, Won Keun. / Influenza A (H1N1) neuraminidase inhibitors from Vitis amurensis. In: Food Chemistry. 2011 ; Vol. 124, No. 2. pp. 437-443.
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Nguyen, TNA, Dao, TT, Tung, BT, Choi, H, Kim, E, Park, J, Lim, SIL & Oh, WK 2011, 'Influenza A (H1N1) neuraminidase inhibitors from Vitis amurensis', Food Chemistry, vol. 124, no. 2, pp. 437-443. https://doi.org/10.1016/j.foodchem.2010.06.049

Influenza A (H1N1) neuraminidase inhibitors from Vitis amurensis. / Nguyen, Thi Ngoc Anh; Dao, Trong Tuan; Tung, Bui Thanh; Choi, Hwanwon; Kim, Eunhee; Park, Junsoo; Lim, Seong I.L.; Oh, Won Keun.

In: Food Chemistry, Vol. 124, No. 2, 01.01.2011, p. 437-443.

Research output: Contribution to journalArticle

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