Inhalation of carbon black nanoparticles aggravates pulmonary inflammation in mice

Devina Saputra, Jin ha Yoon, Hyunju Park, Yongju Heo, Hyoseon Yang, Eun Ji Lee, Sangjin Lee, Chang Woo Song, Kyuhong Lee

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

An increasing number of recent studies have focused on the impact of particulate matter on human health. As a model for atmospheric particulate inhalation, we investigated the effects of inhaled carbon black nanoparticles (CBNP) on mice with bleomycin-induced pulmonary fibrosis. The CNBPs were generated by a novel aerosolization process, and the mice were exposed to the aerosol for 4 hours. We found that CBNP inhalation exacerbated lung inflammation, as evidenced by histopathology analysis and by the expression levels of interleukin-6 protein, fibronectin, and interferon-γ mRNAs in lung tissues. Notably, fibronectin mRNA expression showed a statistically significant increase in expression after CBNP exposure. These data suggest that the concentration of CBNPs delivered (calculated to be 12.5 μg/m3) can aggravate lung inflammation in mice. Our results also suggest that the inhalation of ultrafine particles like PM 2.5 is an impactful environmental risk factor for humans, particularly in susceptible populations with predisposing lung conditions.

Original languageEnglish
Pages (from-to)83-90
Number of pages8
JournalToxicological Research
Volume30
Issue number2
DOIs
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Health, Toxicology and Mutagenesis

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    Saputra, D., Yoon, J. H., Park, H., Heo, Y., Yang, H., Lee, E. J., Lee, S., Song, C. W., & Lee, K. (2014). Inhalation of carbon black nanoparticles aggravates pulmonary inflammation in mice. Toxicological Research, 30(2), 83-90. https://doi.org/10.5487/TR.2014.30.2.083