Inherited and environmental influences on a childhood co-occurring symptom phenotype: Evidence from an adoption study

Leslie E. Roos, Philip A. Fisher, Daniel S. Shaw, Hyoun Kyoung Kim, Jenae M. Neiderhiser, David Reiss, Misake N. Natsuaki, Leslie D. Leve

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Risk factors for the childhood development of co-occurring internalizing and externalizing symptoms are not well understood, despite a high prevalence and poor clinical outcomes associated with this co-occurring phenotype. We examined inherited and environmental risk factors for co-occurring symptoms in a sample of children adopted at birth and their birth mothers and adoptive mothers (N = 293). Inherited risk factors (i.e., birth mothers' processing speed and internalizing symptoms) and environmental risk factors (i.e., adoptive mothers' processing speed, internalizing symptoms, and uninvolved parenting) were examined as predictors for the development of internalizing-only, externalizing-only, or co-occurring symptoms using structural equation modeling. Results suggested a unique pattern of predictive factors for the co-occurring phenotype, with risk conferred by adoptive mothers' uninvolved parenting, birth mothers' slower processing speed, and the birth mothers' slower processing speed in tandem with adoptive mothers' higher internalizing symptoms. Additional analyses indicated that when co-occurring-symptom children were incorporated into internalizing and externalizing symptom groups, differential risk factors for externalizing and internalizing symptoms emerged. The findings suggest that spurious results may be found when children with co-occurring symptoms are not examined as a unique phenotypic group.

Original languageEnglish
Pages (from-to)111-125
Number of pages15
JournalDevelopment and Psychopathology
Volume28
Issue number1
DOIs
Publication statusPublished - 2015 Feb 27

Fingerprint

Mothers
Phenotype
Parturition
Parenting

All Science Journal Classification (ASJC) codes

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

Cite this

Roos, Leslie E. ; Fisher, Philip A. ; Shaw, Daniel S. ; Kim, Hyoun Kyoung ; Neiderhiser, Jenae M. ; Reiss, David ; Natsuaki, Misake N. ; Leve, Leslie D. / Inherited and environmental influences on a childhood co-occurring symptom phenotype : Evidence from an adoption study. In: Development and Psychopathology. 2015 ; Vol. 28, No. 1. pp. 111-125.
@article{567645776c424aeb94afa84dace6f16b,
title = "Inherited and environmental influences on a childhood co-occurring symptom phenotype: Evidence from an adoption study",
abstract = "Risk factors for the childhood development of co-occurring internalizing and externalizing symptoms are not well understood, despite a high prevalence and poor clinical outcomes associated with this co-occurring phenotype. We examined inherited and environmental risk factors for co-occurring symptoms in a sample of children adopted at birth and their birth mothers and adoptive mothers (N = 293). Inherited risk factors (i.e., birth mothers' processing speed and internalizing symptoms) and environmental risk factors (i.e., adoptive mothers' processing speed, internalizing symptoms, and uninvolved parenting) were examined as predictors for the development of internalizing-only, externalizing-only, or co-occurring symptoms using structural equation modeling. Results suggested a unique pattern of predictive factors for the co-occurring phenotype, with risk conferred by adoptive mothers' uninvolved parenting, birth mothers' slower processing speed, and the birth mothers' slower processing speed in tandem with adoptive mothers' higher internalizing symptoms. Additional analyses indicated that when co-occurring-symptom children were incorporated into internalizing and externalizing symptom groups, differential risk factors for externalizing and internalizing symptoms emerged. The findings suggest that spurious results may be found when children with co-occurring symptoms are not examined as a unique phenotypic group.",
author = "Roos, {Leslie E.} and Fisher, {Philip A.} and Shaw, {Daniel S.} and Kim, {Hyoun Kyoung} and Neiderhiser, {Jenae M.} and David Reiss and Natsuaki, {Misake N.} and Leve, {Leslie D.}",
year = "2015",
month = "2",
day = "27",
doi = "10.1017/S0954579415000322",
language = "English",
volume = "28",
pages = "111--125",
journal = "Development and Psychopathology",
issn = "0954-5794",
publisher = "Cambridge University Press",
number = "1",

}

Inherited and environmental influences on a childhood co-occurring symptom phenotype : Evidence from an adoption study. / Roos, Leslie E.; Fisher, Philip A.; Shaw, Daniel S.; Kim, Hyoun Kyoung; Neiderhiser, Jenae M.; Reiss, David; Natsuaki, Misake N.; Leve, Leslie D.

In: Development and Psychopathology, Vol. 28, No. 1, 27.02.2015, p. 111-125.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Inherited and environmental influences on a childhood co-occurring symptom phenotype

T2 - Evidence from an adoption study

AU - Roos, Leslie E.

AU - Fisher, Philip A.

AU - Shaw, Daniel S.

AU - Kim, Hyoun Kyoung

AU - Neiderhiser, Jenae M.

AU - Reiss, David

AU - Natsuaki, Misake N.

AU - Leve, Leslie D.

PY - 2015/2/27

Y1 - 2015/2/27

N2 - Risk factors for the childhood development of co-occurring internalizing and externalizing symptoms are not well understood, despite a high prevalence and poor clinical outcomes associated with this co-occurring phenotype. We examined inherited and environmental risk factors for co-occurring symptoms in a sample of children adopted at birth and their birth mothers and adoptive mothers (N = 293). Inherited risk factors (i.e., birth mothers' processing speed and internalizing symptoms) and environmental risk factors (i.e., adoptive mothers' processing speed, internalizing symptoms, and uninvolved parenting) were examined as predictors for the development of internalizing-only, externalizing-only, or co-occurring symptoms using structural equation modeling. Results suggested a unique pattern of predictive factors for the co-occurring phenotype, with risk conferred by adoptive mothers' uninvolved parenting, birth mothers' slower processing speed, and the birth mothers' slower processing speed in tandem with adoptive mothers' higher internalizing symptoms. Additional analyses indicated that when co-occurring-symptom children were incorporated into internalizing and externalizing symptom groups, differential risk factors for externalizing and internalizing symptoms emerged. The findings suggest that spurious results may be found when children with co-occurring symptoms are not examined as a unique phenotypic group.

AB - Risk factors for the childhood development of co-occurring internalizing and externalizing symptoms are not well understood, despite a high prevalence and poor clinical outcomes associated with this co-occurring phenotype. We examined inherited and environmental risk factors for co-occurring symptoms in a sample of children adopted at birth and their birth mothers and adoptive mothers (N = 293). Inherited risk factors (i.e., birth mothers' processing speed and internalizing symptoms) and environmental risk factors (i.e., adoptive mothers' processing speed, internalizing symptoms, and uninvolved parenting) were examined as predictors for the development of internalizing-only, externalizing-only, or co-occurring symptoms using structural equation modeling. Results suggested a unique pattern of predictive factors for the co-occurring phenotype, with risk conferred by adoptive mothers' uninvolved parenting, birth mothers' slower processing speed, and the birth mothers' slower processing speed in tandem with adoptive mothers' higher internalizing symptoms. Additional analyses indicated that when co-occurring-symptom children were incorporated into internalizing and externalizing symptom groups, differential risk factors for externalizing and internalizing symptoms emerged. The findings suggest that spurious results may be found when children with co-occurring symptoms are not examined as a unique phenotypic group.

UR - http://www.scopus.com/inward/record.url?scp=84954224265&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84954224265&partnerID=8YFLogxK

U2 - 10.1017/S0954579415000322

DO - 10.1017/S0954579415000322

M3 - Article

C2 - 25851306

AN - SCOPUS:84954224265

VL - 28

SP - 111

EP - 125

JO - Development and Psychopathology

JF - Development and Psychopathology

SN - 0954-5794

IS - 1

ER -