Inhibited apoptosis of C2C12 myoblasts by a eupatorium chinense var. simplicifolium root extract

Jin Ho Lee, Min Ho Jung, Yong Hyeon Lee, Yusu Shin, Han Sung Kim, Jürgen Schreiber, Tack Joong Kim

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the effects of a Eupatorium chinense var. simplicifolium (EUC) root extract on muscle disorders and explored the underlying mechanism for oxidative stress-induced C2C12 myoblast damage. An EUC pre-treatment reduced the decreased cell viability after an H2O 2 treatment. The heat shock protein (HSP) 70 level increased, and the phosphorylation of Jun amino-terminal kinases (JNKs) decreased in the EUCpre- treated C2C12 myoblasts. The results of the present study demonstrate the potential benefit of a herbal medicine in treating oxidative stress-related muscle disorders.

Original languageEnglish
Pages (from-to)2134-2136
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume77
Issue number10
DOIs
Publication statusPublished - 2013

Bibliographical note

Funding Information:
This research was supported by the Leading Space Core Technology Development Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2011-00300888), and This research was supported by the Leading Foreign Research Institute Recruitment Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2010-00757).

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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