Inhibition of antigen-induced degranulation by aryl compounds isolated from the bark of Betula platyphylla in RBL-2H3 cells

Seung Hyun Kim; Jung Hyun Park; Tae Bum Kim; Hyang Hwa Lee; Ki Yong Lee; Young Choong Kim; Sang Hyun Sung

doi:10.1016/j.bmcl.2010.03.053

Inhibition of antigen-induced degranulation by aryl compounds isolated from the bark of Betula platyphylla in RBL-2H3 cells

Seung Hyun Kim, Jung Hyun Park, Tae Bum Kim, Hyang Hwa Lee, Ki Yong Lee, Young Choong Kim, Sang Hyun Sung

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

The methanolic extract of the bark of Betula platyphylla was found to suppress antigen mediated degranulation of RBL-2H3 cells. Four arylbutanoids (1-4) and eight diarylhepatonoids (5-12) were isolated from the methanolic extract using bioassay-guided fractionation. Among them, compounds 4 and 12 were isolated and assigned for the first time. Compounds 1, 2, 3, 5, 10, and 12 showed remarkable inhibitory activity against the degranulation of RBL-2H3 by antigen stimulation in a dose dependent manner at the concentrations ranging from 10 μM to 100 μM.

Original language	English
Pages (from-to)	2824-2827
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	9
DOIs	https://doi.org/10.1016/j.bmcl.2010.03.053
Publication status	Published - 2010 May 1

Bibliographical note

Funding Information:
This study was carried out with the support of ‘ Forest Science & Technology Projects ( S120808L1001604C )’ provided by Korea Forest Service.

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2010.03.053

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title = "Inhibition of antigen-induced degranulation by aryl compounds isolated from the bark of Betula platyphylla in RBL-2H3 cells",

abstract = "The methanolic extract of the bark of Betula platyphylla was found to suppress antigen mediated degranulation of RBL-2H3 cells. Four arylbutanoids (1-4) and eight diarylhepatonoids (5-12) were isolated from the methanolic extract using bioassay-guided fractionation. Among them, compounds 4 and 12 were isolated and assigned for the first time. Compounds 1, 2, 3, 5, 10, and 12 showed remarkable inhibitory activity against the degranulation of RBL-2H3 by antigen stimulation in a dose dependent manner at the concentrations ranging from 10 μM to 100 μM.",

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AU - Park, Jung Hyun

AU - Kim, Tae Bum

AU - Lee, Hyang Hwa

AU - Lee, Ki Yong

AU - Kim, Young Choong

AU - Sung, Sang Hyun

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Inhibition of antigen-induced degranulation by aryl compounds isolated from the bark of Betula platyphylla in RBL-2H3 cells

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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