Inhibition of apoptosis in early tooth development alters tooth shape and size

J. Y. Kim, Y. G. Cha, S. W. Cho, E. J. Kim, M. J. Lee, J. M. Lee, J. Cai, H. Ohshima, Hansung Jung

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Apoptosis plays important roles in various stages of organogenesis. In this study, we hypothesized that apoptosis would play an important role in tooth morphogenesis. We examined the role of apoptosis in early tooth development by using a caspase inhibitor, z-VAD-fmk, concomitant with in vitro organ culture and tooth germ transplantation into the kidney capsule. Inhibition of apoptosis at the early cap stage did not disrupt the cell proliferation level when compared with controls. However, the macroscopic morphology of mice molar teeth exhibited dramatic alterations after the inhibition of apoptosis. Crown height was reduced, and mesiodistal diameter was increased in a concentration-dependent manner with z-VAD-fmk treatment. Overall, apoptosis in the enamel knot would be necessary for the proper formation of molar teeth, including appropriate shape and size.

Original languageEnglish
Pages (from-to)530-535
Number of pages6
JournalJournal of Dental Research
Volume85
Issue number6
DOIs
Publication statusPublished - 2006 Jan 1

Fingerprint

Tooth
Apoptosis
Tooth Germ
Caspase Inhibitors
Organogenesis
Organ Culture Techniques
Dental Enamel
Crowns
Morphogenesis
Kidney Transplantation
Capsules
Cell Proliferation
Therapeutics

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

Kim, J. Y. ; Cha, Y. G. ; Cho, S. W. ; Kim, E. J. ; Lee, M. J. ; Lee, J. M. ; Cai, J. ; Ohshima, H. ; Jung, Hansung. / Inhibition of apoptosis in early tooth development alters tooth shape and size. In: Journal of Dental Research. 2006 ; Vol. 85, No. 6. pp. 530-535.
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Kim, JY, Cha, YG, Cho, SW, Kim, EJ, Lee, MJ, Lee, JM, Cai, J, Ohshima, H & Jung, H 2006, 'Inhibition of apoptosis in early tooth development alters tooth shape and size', Journal of Dental Research, vol. 85, no. 6, pp. 530-535. https://doi.org/10.1177/154405910608500610

Inhibition of apoptosis in early tooth development alters tooth shape and size. / Kim, J. Y.; Cha, Y. G.; Cho, S. W.; Kim, E. J.; Lee, M. J.; Lee, J. M.; Cai, J.; Ohshima, H.; Jung, Hansung.

In: Journal of Dental Research, Vol. 85, No. 6, 01.01.2006, p. 530-535.

Research output: Contribution to journalArticle

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