Inhibition of developmental processes by flavone in Caenorhabditis elegans and its application to the pinewood nematode,Bursaphelenchus xylophilus

Yong Uk Lee, Ichiro Kawasaki, Yoongho Lim, Wan Suk Oh, Young Ki Paik, Yhong Hee Shim

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Flavone (2-phenyl chromone) is a well-known plant flavonoid, but its bioactivity has been little explored. Treatment of Caernohabditis elegans. or C. brissage with flavones induced embryonic and larval lethality that was pronounced in early larval stages. This anti-nematodal effect was also observed in the pinewood nematode, B. xylophilus LD50 values were approximately 100 M for both B. xylophilus and C. elegans. Our results indicate that flavone is an active nematicidal compound that should be further investigated with the aim of developing a potent drug against B. xylophilus.

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalMolecules and cells
Volume26
Issue number2
Publication statusPublished - 2008 Aug 31

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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