Inhibition of developmental processes by flavone in Caenorhabditis elegans and its application to the pinewood nematode,Bursaphelenchus xylophilus

Yong Uk Lee, Ichiro Kawasaki, Yoongho Lim, Wan Suk Oh, Young-Ki Paik, Yhong Hee Shim

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Flavone (2-phenyl chromone) is a well-known plant flavonoid, but its bioactivity has been little explored. Treatment of Caernohabditis elegans. or C. brissage with flavones induced embryonic and larval lethality that was pronounced in early larval stages. This anti-nematodal effect was also observed in the pinewood nematode, B. xylophilus LD50 values were approximately 100 M for both B. xylophilus and C. elegans. Our results indicate that flavone is an active nematicidal compound that should be further investigated with the aim of developing a potent drug against B. xylophilus.

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalMolecules and Cells
Volume26
Issue number2
Publication statusPublished - 2008 Aug 31

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flavone
Caenorhabditis elegans
Chromones
Flavones
Lethal Dose 50
Flavonoids
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lee, Yong Uk ; Kawasaki, Ichiro ; Lim, Yoongho ; Oh, Wan Suk ; Paik, Young-Ki ; Shim, Yhong Hee. / Inhibition of developmental processes by flavone in Caenorhabditis elegans and its application to the pinewood nematode,Bursaphelenchus xylophilus. In: Molecules and Cells. 2008 ; Vol. 26, No. 2. pp. 171-174.
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Inhibition of developmental processes by flavone in Caenorhabditis elegans and its application to the pinewood nematode,Bursaphelenchus xylophilus. / Lee, Yong Uk; Kawasaki, Ichiro; Lim, Yoongho; Oh, Wan Suk; Paik, Young-Ki; Shim, Yhong Hee.

In: Molecules and Cells, Vol. 26, No. 2, 31.08.2008, p. 171-174.

Research output: Contribution to journalArticle

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