Inhibition of human ovarian tumor growth by cytokine-induced killer cells

Mook Kim Hwan, Soon Kang Jong, Jaeseung Lim, Song Kyu Park, Kiho Lee, Dae Yoon Yeo, Woo Lee Chang, Hoon Lee Ki, Gyoonhee Han, Kyu Hwan Yang, Jin Kim Yeon, Youngsoo Kim, Sang Bae Han

Research output: Contribution to journalArticle

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Abstract

Despite the recent improvement in the treatment of ovarian cancer, this disease is still leading cause of cancer death in women. In this study, the anti-tumor activity of cytokine-induced killer (CIK) cells against human ovarian cancer was evaluated in vitro and in vivo. Although CD3+CD56 + cells were rare in fresh human peripheral blood mononuclear cells, they could expand more than 1,000-fold on day 14 in the presence of anti-CD3 antibody plus IL-2. At an effector-target cell ratio of 30:1, CIK cells destroyed 45% of SK-OV-3 human ovarian cancer cells, which was determined by the 51Cr-release assay. In addition, CIK cells at a dose of 23 million cells per mouse inhibited 73% of SK-OV-3 tumor growth in nude mouse xenograft assay. This study suggests that CIK cells may be used as an adoptive immunotherapy for patients with ovarian cancer.

Original languageEnglish
Pages (from-to)1464-1470
Number of pages7
JournalArchives of pharmacal research
Volume30
Issue number11
Publication statusPublished - 2007 Nov 30

Fingerprint

Cytokine-Induced Killer Cells
Ovarian Neoplasms
Tumors
Cytokines
Growth
Assays
Neoplasms
Ovarian Diseases
Adoptive Immunotherapy
Heterografts
Nude Mice
Interleukin-2
Cause of Death
Anti-Idiotypic Antibodies
Blood Cells
Blood
Cells
Antibodies

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

Cite this

Hwan, M. K., Jong, S. K., Lim, J., Park, S. K., Lee, K., Yeo, D. Y., ... Han, S. B. (2007). Inhibition of human ovarian tumor growth by cytokine-induced killer cells. Archives of pharmacal research, 30(11), 1464-1470.
Hwan, Mook Kim ; Jong, Soon Kang ; Lim, Jaeseung ; Park, Song Kyu ; Lee, Kiho ; Yeo, Dae Yoon ; Chang, Woo Lee ; Ki, Hoon Lee ; Han, Gyoonhee ; Yang, Kyu Hwan ; Yeon, Jin Kim ; Kim, Youngsoo ; Han, Sang Bae. / Inhibition of human ovarian tumor growth by cytokine-induced killer cells. In: Archives of pharmacal research. 2007 ; Vol. 30, No. 11. pp. 1464-1470.
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Hwan, MK, Jong, SK, Lim, J, Park, SK, Lee, K, Yeo, DY, Chang, WL, Ki, HL, Han, G, Yang, KH, Yeon, JK, Kim, Y & Han, SB 2007, 'Inhibition of human ovarian tumor growth by cytokine-induced killer cells', Archives of pharmacal research, vol. 30, no. 11, pp. 1464-1470.

Inhibition of human ovarian tumor growth by cytokine-induced killer cells. / Hwan, Mook Kim; Jong, Soon Kang; Lim, Jaeseung; Park, Song Kyu; Lee, Kiho; Yeo, Dae Yoon; Chang, Woo Lee; Ki, Hoon Lee; Han, Gyoonhee; Yang, Kyu Hwan; Yeon, Jin Kim; Kim, Youngsoo; Han, Sang Bae.

In: Archives of pharmacal research, Vol. 30, No. 11, 30.11.2007, p. 1464-1470.

Research output: Contribution to journalArticle

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AU - Chang, Woo Lee

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Hwan MK, Jong SK, Lim J, Park SK, Lee K, Yeo DY et al. Inhibition of human ovarian tumor growth by cytokine-induced killer cells. Archives of pharmacal research. 2007 Nov 30;30(11):1464-1470.