Inhibition of human ovarian tumor growth by cytokine-induced killer cells

Mook Kim Hwan, Soon Kang Jong, Jaeseung Lim, Song Kyu Park, Kiho Lee, Dae Yoon Yeo, Woo Lee Chang, Hoon Lee Ki, Gyoonhee Han, Kyu Hwan Yang, Jin Kim Yeon, Youngsoo Kim, Sang Bae Han

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45 Citations (Scopus)

Abstract

Despite the recent improvement in the treatment of ovarian cancer, this disease is still leading cause of cancer death in women. In this study, the anti-tumor activity of cytokine-induced killer (CIK) cells against human ovarian cancer was evaluated in vitro and in vivo. Although CD3+CD56 + cells were rare in fresh human peripheral blood mononuclear cells, they could expand more than 1,000-fold on day 14 in the presence of anti-CD3 antibody plus IL-2. At an effector-target cell ratio of 30:1, CIK cells destroyed 45% of SK-OV-3 human ovarian cancer cells, which was determined by the 51Cr-release assay. In addition, CIK cells at a dose of 23 million cells per mouse inhibited 73% of SK-OV-3 tumor growth in nude mouse xenograft assay. This study suggests that CIK cells may be used as an adoptive immunotherapy for patients with ovarian cancer.

Original languageEnglish
Pages (from-to)1464-1470
Number of pages7
JournalArchives of pharmacal research
Volume30
Issue number11
DOIs
Publication statusPublished - 2007 Nov 30

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Hwan, M. K., Jong, S. K., Lim, J., Park, S. K., Lee, K., Yeo, D. Y., Chang, W. L., Ki, H. L., Han, G., Yang, K. H., Yeon, J. K., Kim, Y., & Han, S. B. (2007). Inhibition of human ovarian tumor growth by cytokine-induced killer cells. Archives of pharmacal research, 30(11), 1464-1470. https://doi.org/10.1007/bf02977372