Inhibitors of osteoclastogenesis from Lawsonia inermis leaves

Nguyen Xuan Cuong, Nguyen Xuan Nhiem, Nguyen Phuong Thao, Nguyen Hoai Nam, Nguyen Tien Dat, Hoang Le Tuan Anh, Le Mai Huong, Phan Van Kiem, Chau Van Minh, Ji Hee Won, Won Yoon Chung, Young Ho Kim

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24 Citations (Scopus)

Abstract

Ten phenolic compounds (1-10) were isolated from a methanol extract of Lawsonia inermis leaves including two new ones, lawsoniasides A (1) and B (2). Their structures were elucidated by spectroscopic methods (NMR and FTICRMS) in combination with acid hydrolysis and GC analyses. Compounds 4 and 5 showed a significant inhibition on receptor activator for nuclear factor-κB ligand-induced osteoclast formation in murine bone-marrow macrophages.

Original languageEnglish
Pages (from-to)4782-4784
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number16
DOIs
Publication statusPublished - 2010 Aug 15

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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  • Cite this

    Cuong, N. X., Nhiem, N. X., Thao, N. P., Nam, N. H., Dat, N. T., Anh, H. L. T., Huong, L. M., Kiem, P. V., Minh, C. V., Won, J. H., Chung, W. Y., & Kim, Y. H. (2010). Inhibitors of osteoclastogenesis from Lawsonia inermis leaves. Bioorganic and Medicinal Chemistry Letters, 20(16), 4782-4784. https://doi.org/10.1016/j.bmcl.2010.06.118