Inhibitors of osteoclastogenesis from Lawsonia inermis leaves

Nguyen Xuan Cuong, Nguyen Xuan Nhiem, Nguyen Phuong Thao, Nguyen Hoai Nam, Nguyen Tien Dat, Hoang Le Tuan Anh, Le Mai Huong, Phan Van Kiem, Chau Van Minh, Ji Hee Won, WonYoon Chung, Young Ho Kim

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Ten phenolic compounds (1-10) were isolated from a methanol extract of Lawsonia inermis leaves including two new ones, lawsoniasides A (1) and B (2). Their structures were elucidated by spectroscopic methods (NMR and FTICRMS) in combination with acid hydrolysis and GC analyses. Compounds 4 and 5 showed a significant inhibition on receptor activator for nuclear factor-κB ligand-induced osteoclast formation in murine bone-marrow macrophages.

Original languageEnglish
Pages (from-to)4782-4784
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number16
DOIs
Publication statusPublished - 2010 Aug 15

Fingerprint

Lawsonia Plant
Macrophages
Osteoclasts
Cytoplasmic and Nuclear Receptors
Osteogenesis
Methanol
Hydrolysis
Bone
Bone Marrow
Nuclear magnetic resonance
Ligands
Acids
lawsoniaside A
lawsoniaside B

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Cuong, N. X., Nhiem, N. X., Thao, N. P., Nam, N. H., Dat, N. T., Anh, H. L. T., ... Kim, Y. H. (2010). Inhibitors of osteoclastogenesis from Lawsonia inermis leaves. Bioorganic and Medicinal Chemistry Letters, 20(16), 4782-4784. https://doi.org/10.1016/j.bmcl.2010.06.118
Cuong, Nguyen Xuan ; Nhiem, Nguyen Xuan ; Thao, Nguyen Phuong ; Nam, Nguyen Hoai ; Dat, Nguyen Tien ; Anh, Hoang Le Tuan ; Huong, Le Mai ; Kiem, Phan Van ; Minh, Chau Van ; Won, Ji Hee ; Chung, WonYoon ; Kim, Young Ho. / Inhibitors of osteoclastogenesis from Lawsonia inermis leaves. In: Bioorganic and Medicinal Chemistry Letters. 2010 ; Vol. 20, No. 16. pp. 4782-4784.
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Cuong, NX, Nhiem, NX, Thao, NP, Nam, NH, Dat, NT, Anh, HLT, Huong, LM, Kiem, PV, Minh, CV, Won, JH, Chung, W & Kim, YH 2010, 'Inhibitors of osteoclastogenesis from Lawsonia inermis leaves', Bioorganic and Medicinal Chemistry Letters, vol. 20, no. 16, pp. 4782-4784. https://doi.org/10.1016/j.bmcl.2010.06.118

Inhibitors of osteoclastogenesis from Lawsonia inermis leaves. / Cuong, Nguyen Xuan; Nhiem, Nguyen Xuan; Thao, Nguyen Phuong; Nam, Nguyen Hoai; Dat, Nguyen Tien; Anh, Hoang Le Tuan; Huong, Le Mai; Kiem, Phan Van; Minh, Chau Van; Won, Ji Hee; Chung, WonYoon; Kim, Young Ho.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 20, No. 16, 15.08.2010, p. 4782-4784.

Research output: Contribution to journalArticle

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AU - Anh, Hoang Le Tuan

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AU - Minh, Chau Van

AU - Won, Ji Hee

AU - Chung, WonYoon

AU - Kim, Young Ho

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