Inhibitory alkaloids from Dictamnus dasycarpus root barks on lipopolysaccharide-induced nitric oxide production in BV2 cells

Jeong Seon Yoon, Eun Ju Jeong, Hyekyung Yang, Seung Hyun Kim, Sang Hyun Sung, Young Choong Kim

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The methanolic extract of Dictamnus dasycarpus root barks afforded one new glycosidic quinoline alkaloid, 3-[1β-hydroxy-2-(β-D-glucopyranosyloxy) -ethyl)-4-methoxy-2(1H)-quinolinone (1), together with nine known compounds, preskimmianine (2), 8-methoxy-N-methylflindersine (3), dictamine (4), γ-fagarine (5), halopine (6), skimmianine (7), dictangustine-A (8), iso-γ-fagarine (9), isomaculosidine (10). The isolated alkaloids significantly inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells. Among them, compounds 3 and 7 showed the most potent inhibitory activities on LPS-induced NO production.

Original languageEnglish
Pages (from-to)490-494
Number of pages5
JournalJournal of Enzyme Inhibition and Medicinal Chemistry
Volume27
Issue number4
DOIs
Publication statusPublished - 2012 Aug 1

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Dictamnus
Alkaloids
Lipopolysaccharides
Nitric Oxide

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

Yoon, Jeong Seon ; Jeong, Eun Ju ; Yang, Hyekyung ; Kim, Seung Hyun ; Sung, Sang Hyun ; Kim, Young Choong. / Inhibitory alkaloids from Dictamnus dasycarpus root barks on lipopolysaccharide-induced nitric oxide production in BV2 cells. In: Journal of Enzyme Inhibition and Medicinal Chemistry. 2012 ; Vol. 27, No. 4. pp. 490-494.
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Inhibitory alkaloids from Dictamnus dasycarpus root barks on lipopolysaccharide-induced nitric oxide production in BV2 cells. / Yoon, Jeong Seon; Jeong, Eun Ju; Yang, Hyekyung; Kim, Seung Hyun; Sung, Sang Hyun; Kim, Young Choong.

In: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 27, No. 4, 01.08.2012, p. 490-494.

Research output: Contribution to journalArticle

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