Inhibitory alkaloids from Dictamnus dasycarpus root barks on lipopolysaccharide-induced nitric oxide production in BV2 cells

Jeong Seon Yoon, Eun Ju Jeong, Hyekyung Yang, Seung Hyun Kim, Sang Hyun Sung, Young Choong Kim

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The methanolic extract of Dictamnus dasycarpus root barks afforded one new glycosidic quinoline alkaloid, 3-[1β-hydroxy-2-(β-D-glucopyranosyloxy) -ethyl)-4-methoxy-2(1H)-quinolinone (1), together with nine known compounds, preskimmianine (2), 8-methoxy-N-methylflindersine (3), dictamine (4), γ-fagarine (5), halopine (6), skimmianine (7), dictangustine-A (8), iso-γ-fagarine (9), isomaculosidine (10). The isolated alkaloids significantly inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells. Among them, compounds 3 and 7 showed the most potent inhibitory activities on LPS-induced NO production.

Original languageEnglish
Pages (from-to)490-494
Number of pages5
JournalJournal of Enzyme Inhibition and Medicinal Chemistry
Volume27
Issue number4
DOIs
Publication statusPublished - 2012 Aug

Bibliographical note

Funding Information:
This research was supported by a grant (2011K000290) from Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Education, Science and Technology, the Republic of Korea.

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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