Inhibitory alkaloids from Dictamnus dasycarpus root barks on lipopolysaccharide-induced nitric oxide production in BV2 cells

Jeong Seon Yoon, Eun Ju Jeong, Hyekyung Yang, Seung Hyun Kim, Sang Hyun Sung, Young Choong Kim

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The methanolic extract of Dictamnus dasycarpus root barks afforded one new glycosidic quinoline alkaloid, 3-[1β-hydroxy-2-(β-D-glucopyranosyloxy) -ethyl)-4-methoxy-2(1H)-quinolinone (1), together with nine known compounds, preskimmianine (2), 8-methoxy-N-methylflindersine (3), dictamine (4), γ-fagarine (5), halopine (6), skimmianine (7), dictangustine-A (8), iso-γ-fagarine (9), isomaculosidine (10). The isolated alkaloids significantly inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells. Among them, compounds 3 and 7 showed the most potent inhibitory activities on LPS-induced NO production.

Original languageEnglish
Pages (from-to)490-494
Number of pages5
JournalJournal of Enzyme Inhibition and Medicinal Chemistry
Volume27
Issue number4
DOIs
Publication statusPublished - 2012 Aug 1

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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