Inhibitory constituents of Euonymus alatus leaves and twigs on nitric oxide production in BV2 microglia cells

Eun Ju Jeong, Heejung Yang, Seung Hyun Kim, So Young Kang, Sang Hyun Sung, Young Choong Kim

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The excessive and prolonged nitric oxide (NO) production has been linked to various inflammatory diseases as well as tumourigenesis. On the search for anti-inflammatory and anti-cancer compounds from the medicinal plants, the methanolic extract of Euonymus alatus (Thunb.) Sieb. (Celastraceae) was found to have significant inhibitory activity on NO production in lipopolysaccharide (LPS)-stimulated BV2 microglia cells. Hence, we attempted to isolate the inhibitory constituent of E. alatus leaves and twigs on NO production. Thirteen compounds including two new glycerol derivates (1, 2), two C13 isoprenoids (3, 4), two phenolics (5, 6) and seven flavonoids (7-13) were isolated, and the structures of 1-13 were elucidated by extensive 1D and 2D spectroscopic methods. The isolated compounds significantly inhibited NO production induced by LPS in BV2 microglia cells.

Original languageEnglish
Pages (from-to)1394-1398
Number of pages5
JournalFood and Chemical Toxicology
Volume49
Issue number6
DOIs
Publication statusPublished - 2011 Jun 1

All Science Journal Classification (ASJC) codes

  • Food Science
  • Toxicology

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