Inhibitory constituents of lipopolysaccharide-induced nitric oxide production in BV2 microglia isolated from Amomum tsao-ko

Ki Yong Lee, Seung Hyun Kim, Sang Hyun Sung, Young Choong Kim

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A methanolic extract of the fruits of Amomum tsao-ko (Zingiber-aceae) significantly attenuated nitric oxide production in lipopo-lysaccharide- simulated BV2 microglia. Two new bicyclic nonanes characterized as 6,7-dihydroxy-indan-4-carbaldehyde (1) and 6-hydroxy-indan-4-carbaldehyde (2) were isolated with the eleven known compounds 6,7-dihydroxy-3,7-dimethyloct-2- enoic acid (3), tsaokoin (4), isotsaokoin (5), 8-oxogeraniol (6), p-menth-l-ene-5,6-diol (7), 3α-hydroxycarvotagenone (8), tsao-koarylone (9), l,7-bis(4-hydroxy-3-methoxyphenyl)-4,6-hepta-dien-3one (10), (+)-hannokinol (11), meso-hannokinol (12) and hannokinin (13), from the fruits of A tsao-ko using bioactivity-guided fractionation. All thirteen compounds significantly inhibited lipopolysaccharide-induced nitric oxide production in BV2 microglial cells at concentrations ranging from 1 μM to 100 μM.

Original languageEnglish
Pages (from-to)867-869
Number of pages3
JournalPlanta Medica
Volume74
Issue number8
DOIs
Publication statusPublished - 2008 Jun 1

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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