Inhibitory effect of ERK1/2 and AP-1 by hyperoside isolated from Acanthopanax sessiliflorus

Sung Keun Jung, Tae Gyu Lim, Jong Eun Kim, Sanguine Byun, Gye Won Kim, Jung Nam Choi, Choong Hwan Lee, Bo Yeon Kim, Ki Won Lee, Hyong Joo Lee

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9 Citations (Scopus)

Abstract

Consumption of fruits and vegetables is correlated with a lower incidence of cancer. Here, we identified hyperoside as an active compound from Acanthopanax sessiliflorus, and investigated the effect of hyperoside on UVB-induced transactivation of activator protein 1 (AP-1) and on the mitogen-activated protein kinase signalling pathway in JB6 P + cells. Hyperoside inhibited UVB-induced AP-1 transactivation. It inhibited the UVB-induced phosphorylation of p90RSK. Kinase assays revealed that hyperoside significantly inhibited ERK1/2 activity. Furthermore, hyperoside bound to ERK1/2 to suppress its activity. In addition, phosphorylation of cAMP response element binding protein (CREB) and signal transducers and activators of transcription (STAT) 3 were suppressed by hyperoside. Overall, these results indicate that hyperoside may be a promising chemopreventive agent that acts by suppressing the transactivation of AP-1 and the phosphorylation of p90RSK, CREB, and STAT3 through the binding and inhibition of ERK1/2.

Original languageEnglish
Pages (from-to)915-920
Number of pages6
JournalFood Chemistry
Volume130
Issue number4
DOIs
Publication statusPublished - 2012 Feb 15

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Food Science

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    Jung, S. K., Lim, T. G., Kim, J. E., Byun, S., Kim, G. W., Choi, J. N., Lee, C. H., Kim, B. Y., Lee, K. W., & Lee, H. J. (2012). Inhibitory effect of ERK1/2 and AP-1 by hyperoside isolated from Acanthopanax sessiliflorus. Food Chemistry, 130(4), 915-920. https://doi.org/10.1016/j.foodchem.2011.08.010