Inhibitory effect of ethyl acetate extract of white peach pericarp on adipogenesis of 3T3-L1 preadipocyte cells

Hong Gyu Park, Jin Moon Kim, Jung Mogg Kim, Won Yoon Chung, Yun Jung Yoo, Jeong Heon Cha

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In order to determine whether peach contains compounds to regulate adipocyte differentiation, extracts of flesh/ pericarp of yellow/white peach were prepared in water, ethyl acetate (EtOAc), or n-butanol solvent and determined for effects on adipocyte differentiation in C3H10T1/2 or 3T3-L1 cells. Interestingly, none of peach extracts has statistically significant stimulatory effect on the adipocyte differentiation in C3H10T1/2. Furthermore, the presence of EtOAc extract of white peach pericarp (WPP) was found to inhibit lipid accumulation in 3T3-L1 cells both by microscopic examination of Oil Red O-stained lipid droplets and by spectrophotometric quantification of extracted stain, indicating a significant inhibitory effect on adipocyte differentiation. The inhibition of lipid accumulation was accompanied by a significant decrease in the expression levels of adipocyte molecular markers-peroxisome proliferator-activated receptor γ, CAAT enhancer binding protein α, and fatty acid-binding protein. Thus, this study determined that WPP EtOAc extract contains the inhibitory compound(s) on adipogenesis.

Original languageEnglish
Pages (from-to)1327-1331
Number of pages5
JournalFood Science and Biotechnology
Issue number6
Publication statusPublished - 2008 Dec 1


All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology

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