Inhibitory effect of standardized curcuma xanthorrhiza supercritical extract on LPS-induced periodontitis in rats

Kyo Eun Kook, Changhee Kim, Wonku Kang, Jae Kwan Hwang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Periodontitis, which is a severe inflammatory disease caused by endotoxins secreted from oral pathogens, destructs gingival tissue and alveolar bone. Curcuma xanthorrhiza, commonly called Java turmeric, has been shown to possess anti-bacterial and anti-inflammatory activities. The present study evaluated the inhibitory effect of C. xanthorrhiza supercritical extract (CXS) standardized with xanthorrhizol on lipopolysaccharide (LPS)-induced periodontitis in an animal model. LPS was topically injected into the periodontium of Sprague-Dawley rats to induce periodontitis and CXS (30 and 100 mg·kg -1 ·day -1 ) was orally administered after day 12. Histologically, CXS inhibited the collapse of gingival tissue by preventing cell infiltration. CXS significantly downregulated the expression of matrix metalloproteases (MMPs) and inflammation-related biomarkers, such as nuclear factor-kappa B (NF-κB) and interleukin-1 beta (IL-1β) in gingival tissue. CXS also improved bone remodeling by downregulating osteoclastic transcription factors, such as nuclear factor of activated T-cells c1 (NFATc1), tartrate-resistant acid phosphatase (TRAP), and cathepsin K. In addition, CXS upregulated osteoblast differentiation-related markers, alkaline phosphate (ALP) and collagen type I alpha (COLA1). Thus, CXS can ameliorate periodontitis by inhibiting inflammation and improving bone remodeling.

Original languageEnglish
Pages (from-to)1614-1625
Number of pages12
JournalJournal of microbiology and biotechnology
Volume28
Issue number10
DOIs
Publication statusPublished - 2018 Oct

Fingerprint

Curcuma
Periodontitis
Lipopolysaccharides
Bone Remodeling
Down-Regulation
Cathepsin K
NFATC Transcription Factors
Inflammation
Periodontium
NF-kappa B
Differentiation Antigens
Metalloproteases
Collagen Type I
Osteoblasts
Interleukin-1beta
Endotoxins
Sprague Dawley Rats
Anti-Inflammatory Agents
Transcription Factors
Animal Models

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

@article{8ca74bd3653c47a79b9cd94b0bc96bb2,
title = "Inhibitory effect of standardized curcuma xanthorrhiza supercritical extract on LPS-induced periodontitis in rats",
abstract = "Periodontitis, which is a severe inflammatory disease caused by endotoxins secreted from oral pathogens, destructs gingival tissue and alveolar bone. Curcuma xanthorrhiza, commonly called Java turmeric, has been shown to possess anti-bacterial and anti-inflammatory activities. The present study evaluated the inhibitory effect of C. xanthorrhiza supercritical extract (CXS) standardized with xanthorrhizol on lipopolysaccharide (LPS)-induced periodontitis in an animal model. LPS was topically injected into the periodontium of Sprague-Dawley rats to induce periodontitis and CXS (30 and 100 mg·kg -1 ·day -1 ) was orally administered after day 12. Histologically, CXS inhibited the collapse of gingival tissue by preventing cell infiltration. CXS significantly downregulated the expression of matrix metalloproteases (MMPs) and inflammation-related biomarkers, such as nuclear factor-kappa B (NF-κB) and interleukin-1 beta (IL-1β) in gingival tissue. CXS also improved bone remodeling by downregulating osteoclastic transcription factors, such as nuclear factor of activated T-cells c1 (NFATc1), tartrate-resistant acid phosphatase (TRAP), and cathepsin K. In addition, CXS upregulated osteoblast differentiation-related markers, alkaline phosphate (ALP) and collagen type I alpha (COLA1). Thus, CXS can ameliorate periodontitis by inhibiting inflammation and improving bone remodeling.",
author = "Kook, {Kyo Eun} and Changhee Kim and Wonku Kang and Hwang, {Jae Kwan}",
year = "2018",
month = "10",
doi = "10.4014/jmb.1808.08052",
language = "English",
volume = "28",
pages = "1614--1625",
journal = "Journal of Microbiology and Biotechnology",
issn = "1017-7825",
publisher = "Korean Society for Microbiolog and Biotechnology",
number = "10",

}

Inhibitory effect of standardized curcuma xanthorrhiza supercritical extract on LPS-induced periodontitis in rats. / Kook, Kyo Eun; Kim, Changhee; Kang, Wonku; Hwang, Jae Kwan.

In: Journal of microbiology and biotechnology, Vol. 28, No. 10, 10.2018, p. 1614-1625.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Inhibitory effect of standardized curcuma xanthorrhiza supercritical extract on LPS-induced periodontitis in rats

AU - Kook, Kyo Eun

AU - Kim, Changhee

AU - Kang, Wonku

AU - Hwang, Jae Kwan

PY - 2018/10

Y1 - 2018/10

N2 - Periodontitis, which is a severe inflammatory disease caused by endotoxins secreted from oral pathogens, destructs gingival tissue and alveolar bone. Curcuma xanthorrhiza, commonly called Java turmeric, has been shown to possess anti-bacterial and anti-inflammatory activities. The present study evaluated the inhibitory effect of C. xanthorrhiza supercritical extract (CXS) standardized with xanthorrhizol on lipopolysaccharide (LPS)-induced periodontitis in an animal model. LPS was topically injected into the periodontium of Sprague-Dawley rats to induce periodontitis and CXS (30 and 100 mg·kg -1 ·day -1 ) was orally administered after day 12. Histologically, CXS inhibited the collapse of gingival tissue by preventing cell infiltration. CXS significantly downregulated the expression of matrix metalloproteases (MMPs) and inflammation-related biomarkers, such as nuclear factor-kappa B (NF-κB) and interleukin-1 beta (IL-1β) in gingival tissue. CXS also improved bone remodeling by downregulating osteoclastic transcription factors, such as nuclear factor of activated T-cells c1 (NFATc1), tartrate-resistant acid phosphatase (TRAP), and cathepsin K. In addition, CXS upregulated osteoblast differentiation-related markers, alkaline phosphate (ALP) and collagen type I alpha (COLA1). Thus, CXS can ameliorate periodontitis by inhibiting inflammation and improving bone remodeling.

AB - Periodontitis, which is a severe inflammatory disease caused by endotoxins secreted from oral pathogens, destructs gingival tissue and alveolar bone. Curcuma xanthorrhiza, commonly called Java turmeric, has been shown to possess anti-bacterial and anti-inflammatory activities. The present study evaluated the inhibitory effect of C. xanthorrhiza supercritical extract (CXS) standardized with xanthorrhizol on lipopolysaccharide (LPS)-induced periodontitis in an animal model. LPS was topically injected into the periodontium of Sprague-Dawley rats to induce periodontitis and CXS (30 and 100 mg·kg -1 ·day -1 ) was orally administered after day 12. Histologically, CXS inhibited the collapse of gingival tissue by preventing cell infiltration. CXS significantly downregulated the expression of matrix metalloproteases (MMPs) and inflammation-related biomarkers, such as nuclear factor-kappa B (NF-κB) and interleukin-1 beta (IL-1β) in gingival tissue. CXS also improved bone remodeling by downregulating osteoclastic transcription factors, such as nuclear factor of activated T-cells c1 (NFATc1), tartrate-resistant acid phosphatase (TRAP), and cathepsin K. In addition, CXS upregulated osteoblast differentiation-related markers, alkaline phosphate (ALP) and collagen type I alpha (COLA1). Thus, CXS can ameliorate periodontitis by inhibiting inflammation and improving bone remodeling.

UR - http://www.scopus.com/inward/record.url?scp=85065180574&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065180574&partnerID=8YFLogxK

U2 - 10.4014/jmb.1808.08052

DO - 10.4014/jmb.1808.08052

M3 - Article

C2 - 30196591

AN - SCOPUS:85065180574

VL - 28

SP - 1614

EP - 1625

JO - Journal of Microbiology and Biotechnology

JF - Journal of Microbiology and Biotechnology

SN - 1017-7825

IS - 10

ER -