Inhibitory effects of α- and β-carotene on croton oil-induced or enzymatic lipid peroxidation and hydroperoxide production in mouse skin epidermis

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

1. 1. The effects of carotenes (α- and β-) on edema, MDA contents and peroxidizability ofcroton oil-treated mouse skin epidermis, hydroperoxide production and enzymatic lipid peroxidation of epidermal homogenates were studied. Edema was determined as ear punch weight and the intensity of lipid peroxidation was measured using malondialdehyde formation. 2. 2. Carotenes (α- and β-) significantly suppressed edema formation, hydroperoxide production, lipid peroxidation caused by croton oil, Fe + 3-ADP/NADPH or paraquat/NADPH in vivo as well as in vitro. 3. 3. These results indicate that both α- and β-carotene have chemopreventive effects on croton oil-induced tumor promotion in skin tumorigenesis by scavenging oxygen free radicals, indirectly determined as carotene inhibition of lipid peroxidation and hydroperoxide formation.

Original languageEnglish
Pages (from-to)911-915
Number of pages5
JournalInternational Journal of Biochemistry
Volume25
Issue number6
DOIs
Publication statusPublished - 1993 Jan 1

Fingerprint

Croton Oil
Lipid Peroxides
Carotenoids
Epidermis
Hydrogen Peroxide
Lipid Peroxidation
Skin
Lipids
Edema
NADP
Paraquat
Scavenging
Malondialdehyde
Free Radicals
Ear
Tumors
Reactive Oxygen Species
Oils
Carcinogenesis
Oxygen

All Science Journal Classification (ASJC) codes

  • Biochemistry

Cite this

@article{f33c7317c4914feb8570b6e1f4707f70,
title = "Inhibitory effects of α- and β-carotene on croton oil-induced or enzymatic lipid peroxidation and hydroperoxide production in mouse skin epidermis",
abstract = "1. 1. The effects of carotenes (α- and β-) on edema, MDA contents and peroxidizability ofcroton oil-treated mouse skin epidermis, hydroperoxide production and enzymatic lipid peroxidation of epidermal homogenates were studied. Edema was determined as ear punch weight and the intensity of lipid peroxidation was measured using malondialdehyde formation. 2. 2. Carotenes (α- and β-) significantly suppressed edema formation, hydroperoxide production, lipid peroxidation caused by croton oil, Fe + 3-ADP/NADPH or paraquat/NADPH in vivo as well as in vitro. 3. 3. These results indicate that both α- and β-carotene have chemopreventive effects on croton oil-induced tumor promotion in skin tumorigenesis by scavenging oxygen free radicals, indirectly determined as carotene inhibition of lipid peroxidation and hydroperoxide formation.",
author = "Kim, {Hye Young}",
year = "1993",
month = "1",
day = "1",
doi = "10.1016/0020-711X(93)90247-C",
language = "English",
volume = "25",
pages = "911--915",
journal = "International Journal of Biochemistry and Cell Biology",
issn = "1357-2725",
publisher = "Elsevier Limited",
number = "6",

}

TY - JOUR

T1 - Inhibitory effects of α- and β-carotene on croton oil-induced or enzymatic lipid peroxidation and hydroperoxide production in mouse skin epidermis

AU - Kim, Hye Young

PY - 1993/1/1

Y1 - 1993/1/1

N2 - 1. 1. The effects of carotenes (α- and β-) on edema, MDA contents and peroxidizability ofcroton oil-treated mouse skin epidermis, hydroperoxide production and enzymatic lipid peroxidation of epidermal homogenates were studied. Edema was determined as ear punch weight and the intensity of lipid peroxidation was measured using malondialdehyde formation. 2. 2. Carotenes (α- and β-) significantly suppressed edema formation, hydroperoxide production, lipid peroxidation caused by croton oil, Fe + 3-ADP/NADPH or paraquat/NADPH in vivo as well as in vitro. 3. 3. These results indicate that both α- and β-carotene have chemopreventive effects on croton oil-induced tumor promotion in skin tumorigenesis by scavenging oxygen free radicals, indirectly determined as carotene inhibition of lipid peroxidation and hydroperoxide formation.

AB - 1. 1. The effects of carotenes (α- and β-) on edema, MDA contents and peroxidizability ofcroton oil-treated mouse skin epidermis, hydroperoxide production and enzymatic lipid peroxidation of epidermal homogenates were studied. Edema was determined as ear punch weight and the intensity of lipid peroxidation was measured using malondialdehyde formation. 2. 2. Carotenes (α- and β-) significantly suppressed edema formation, hydroperoxide production, lipid peroxidation caused by croton oil, Fe + 3-ADP/NADPH or paraquat/NADPH in vivo as well as in vitro. 3. 3. These results indicate that both α- and β-carotene have chemopreventive effects on croton oil-induced tumor promotion in skin tumorigenesis by scavenging oxygen free radicals, indirectly determined as carotene inhibition of lipid peroxidation and hydroperoxide formation.

UR - http://www.scopus.com/inward/record.url?scp=0027314637&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027314637&partnerID=8YFLogxK

U2 - 10.1016/0020-711X(93)90247-C

DO - 10.1016/0020-711X(93)90247-C

M3 - Article

C2 - 8344446

AN - SCOPUS:0027314637

VL - 25

SP - 911

EP - 915

JO - International Journal of Biochemistry and Cell Biology

JF - International Journal of Biochemistry and Cell Biology

SN - 1357-2725

IS - 6

ER -