Inhibitory effects of Boesenbergia pandurata on age-related periodontal inflammation and alveolar bone loss in fischer 344 rats

Haebom Kim, Changhee Kim, Do Un Kim, Hee Chul Chung, Jae-Kwan Hwang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Periodontitis, an infective disease caused by oral pathogens and the intrinsic aging process, results in the destruction of periodontal tissues and the loss of alveolar bone. This study investigated whether Boesenbergia pandurata extract (BPE) standardized with panduratin A exerted anti-periodontitis effects, using an aging model representative of naturally occurring periodontitis. In aged rats, the oral administration of BPE (200 mg·kg-1·day-1) for 8 weeks significantly reduced the mRNA and protein expression of interleukin-1β, nuclear factorkappa B, matrix metalloproteinase (MMP)-2, and MMP-8 in gingival tissues (p < 0.01). In alveolar bone, histological analysis with staining and micro-computed tomography revealed the attenuation of alveolar bone resorption in the BPE-treated aged group, which led to a significant reduction in the mRNA and protein expression of nuclear factor of activated T-cells c1 (NFATc1), c-Fos, tartrate-resistant acid phosphatase, and cathepsin K (p < 0.01). BPE not only increased the expression of osteoblast differentiation markers, such as alkaline phosphate, and collagen type I (COL1A1), but also increased the ratio of osteoprotegerin to RANKL. Collectively, the results strongly suggested that BPE is a natural resource for the prevention or treatment of periodontal diseases.

Original languageEnglish
Pages (from-to)357-366
Number of pages10
JournalJournal of microbiology and biotechnology
Volume28
Issue number3
DOIs
Publication statusPublished - 2018 Mar 1

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Zingiberaceae
Alveolar Bone Loss
Inbred F344 Rats
Periodontitis
Inflammation
Cathepsin K
Matrix Metalloproteinase 8
NFATC Transcription Factors
Osteoprotegerin
Messenger RNA
Matrix Metalloproteinase 2
Differentiation Antigens
Periodontal Diseases
Bone Resorption
Collagen Type I
Osteoblasts
Interleukin-1
Oral Administration
Proteins
Phosphates

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

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title = "Inhibitory effects of Boesenbergia pandurata on age-related periodontal inflammation and alveolar bone loss in fischer 344 rats",
abstract = "Periodontitis, an infective disease caused by oral pathogens and the intrinsic aging process, results in the destruction of periodontal tissues and the loss of alveolar bone. This study investigated whether Boesenbergia pandurata extract (BPE) standardized with panduratin A exerted anti-periodontitis effects, using an aging model representative of naturally occurring periodontitis. In aged rats, the oral administration of BPE (200 mg·kg-1·day-1) for 8 weeks significantly reduced the mRNA and protein expression of interleukin-1β, nuclear factorkappa B, matrix metalloproteinase (MMP)-2, and MMP-8 in gingival tissues (p < 0.01). In alveolar bone, histological analysis with staining and micro-computed tomography revealed the attenuation of alveolar bone resorption in the BPE-treated aged group, which led to a significant reduction in the mRNA and protein expression of nuclear factor of activated T-cells c1 (NFATc1), c-Fos, tartrate-resistant acid phosphatase, and cathepsin K (p < 0.01). BPE not only increased the expression of osteoblast differentiation markers, such as alkaline phosphate, and collagen type I (COL1A1), but also increased the ratio of osteoprotegerin to RANKL. Collectively, the results strongly suggested that BPE is a natural resource for the prevention or treatment of periodontal diseases.",
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Inhibitory effects of Boesenbergia pandurata on age-related periodontal inflammation and alveolar bone loss in fischer 344 rats. / Kim, Haebom; Kim, Changhee; Kim, Do Un; Chung, Hee Chul; Hwang, Jae-Kwan.

In: Journal of microbiology and biotechnology, Vol. 28, No. 3, 01.03.2018, p. 357-366.

Research output: Contribution to journalArticle

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AB - Periodontitis, an infective disease caused by oral pathogens and the intrinsic aging process, results in the destruction of periodontal tissues and the loss of alveolar bone. This study investigated whether Boesenbergia pandurata extract (BPE) standardized with panduratin A exerted anti-periodontitis effects, using an aging model representative of naturally occurring periodontitis. In aged rats, the oral administration of BPE (200 mg·kg-1·day-1) for 8 weeks significantly reduced the mRNA and protein expression of interleukin-1β, nuclear factorkappa B, matrix metalloproteinase (MMP)-2, and MMP-8 in gingival tissues (p < 0.01). In alveolar bone, histological analysis with staining and micro-computed tomography revealed the attenuation of alveolar bone resorption in the BPE-treated aged group, which led to a significant reduction in the mRNA and protein expression of nuclear factor of activated T-cells c1 (NFATc1), c-Fos, tartrate-resistant acid phosphatase, and cathepsin K (p < 0.01). BPE not only increased the expression of osteoblast differentiation markers, such as alkaline phosphate, and collagen type I (COL1A1), but also increased the ratio of osteoprotegerin to RANKL. Collectively, the results strongly suggested that BPE is a natural resource for the prevention or treatment of periodontal diseases.

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