Inhibitory effects of chlorophyllin on 7,12-dimethylbenz[a]anthracene-induced bacterial mutagenesis and mouse skin carcinogenesis

Won Yoon Chung, Jong Min Lee, Mi Young Park, Jong In Yook, Jin Kim, An Sik Chung, Young Joon Surh, Kwang Kyun Park

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Chlorophyllin (CHL), a water-soluble derivative of chlorophyll, has been used for the treatment of several abnormal human conditions without apparent toxicity. Recent studies have revealed that CHL has the excellent chemopreventive potential. In the present investigation, we have found the inhibitory activities of CHL against 7,12-dimethylbenz[a]anthracene (DMBA)-induced mutagenesis in Salmonella typhimurium TA100 and also on DMBA-initiated and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-promoted mouse skin tumor formation. The incidence and the multiplicity of skin tumors were not significantly decreased in mice by a single topical application of CHL prior to the DMBA treatment, but there was a marked suppression of papillomagenesis in mice treated with CHL during the promotional stage. Furthermore, the formation of DMBA-induced papillomagenesis was reduced in all mice that had received CHL for 6 weeks following treatment with TPA for 6, 18 and 24 weeks. These results indicate that CHL can inhibit both tumor promotion and the progression of papillomagenesis in the two-stage mouse skin carcinogenesis induced by DMBA and TPA.

Original languageEnglish
Pages (from-to)57-64
Number of pages8
JournalCancer Letters
Volume145
Issue number1-2
DOIs
Publication statusPublished - 1999 Oct 18

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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