Abstract
The aim of this study was to investigate the in vitro inhibitory effects of macelignan isolated from Myristica fragrans HOUTT. on melanogenesis and its related enzymes such as tyrosinase, tyrosinase-related protein-1 (TRP-1), and tyrosinase-related protein-2 (TRP-2) in melan-a murine melanocytes. The IC 50 values of macelignan for melanogenesis and tyrosinase were 13 μM and 30 μM, respectively, while those of arbutin as a positive control were 990 μM and 660 μM, respectively. In Western blot analysis, macelignan also significantly decreased tyrosinase, TRP-1, and TRP-2 protein expression. These results indicate that macelignan effectively inhibits melanin biosynthesis and thus could be employed as a new skin-whitening agent.
| Original language | English |
|---|---|
| Pages (from-to) | 986-989 |
| Number of pages | 4 |
| Journal | Biological and Pharmaceutical Bulletin |
| Volume | 31 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2008 May 1 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
- Pharmaceutical Science
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Inhibitory effects of macelignan isolated from Myristica fragrans Houtt. on melanin biosynthesis. / Cho, Yumi; Kim, Kyu Hoi; Shim, Jae Seok; Hwang, Jae Kwan.
In: Biological and Pharmaceutical Bulletin, Vol. 31, No. 5, 01.05.2008, p. 986-989.Research output: Contribution to journal › Article
TY - JOUR
T1 - Inhibitory effects of macelignan isolated from Myristica fragrans Houtt. on melanin biosynthesis
AU - Cho, Yumi
AU - Kim, Kyu Hoi
AU - Shim, Jae Seok
AU - Hwang, Jae Kwan
PY - 2008/5/1
Y1 - 2008/5/1
N2 - The aim of this study was to investigate the in vitro inhibitory effects of macelignan isolated from Myristica fragrans HOUTT. on melanogenesis and its related enzymes such as tyrosinase, tyrosinase-related protein-1 (TRP-1), and tyrosinase-related protein-2 (TRP-2) in melan-a murine melanocytes. The IC 50 values of macelignan for melanogenesis and tyrosinase were 13 μM and 30 μM, respectively, while those of arbutin as a positive control were 990 μM and 660 μM, respectively. In Western blot analysis, macelignan also significantly decreased tyrosinase, TRP-1, and TRP-2 protein expression. These results indicate that macelignan effectively inhibits melanin biosynthesis and thus could be employed as a new skin-whitening agent.
AB - The aim of this study was to investigate the in vitro inhibitory effects of macelignan isolated from Myristica fragrans HOUTT. on melanogenesis and its related enzymes such as tyrosinase, tyrosinase-related protein-1 (TRP-1), and tyrosinase-related protein-2 (TRP-2) in melan-a murine melanocytes. The IC 50 values of macelignan for melanogenesis and tyrosinase were 13 μM and 30 μM, respectively, while those of arbutin as a positive control were 990 μM and 660 μM, respectively. In Western blot analysis, macelignan also significantly decreased tyrosinase, TRP-1, and TRP-2 protein expression. These results indicate that macelignan effectively inhibits melanin biosynthesis and thus could be employed as a new skin-whitening agent.
UR - http://www.scopus.com/inward/record.url?scp=44349115020&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=44349115020&partnerID=8YFLogxK
U2 - 10.1248/bpb.31.986
DO - 10.1248/bpb.31.986
M3 - Article
C2 - 18451531
AN - SCOPUS:44349115020
VL - 31
SP - 986
EP - 989
JO - Biological and Pharmaceutical Bulletin
JF - Biological and Pharmaceutical Bulletin
SN - 0918-6158
IS - 5
ER -