TY - JOUR
T1 - Inhibitory effects of macelignan isolated from Myristica fragrans Houtt. on melanin biosynthesis
AU - Cho, Yumi
AU - Kim, Kyu Hoi
AU - Shim, Jae Seok
AU - Hwang, Jae Kwan
PY - 2008/5
Y1 - 2008/5
N2 - The aim of this study was to investigate the in vitro inhibitory effects of macelignan isolated from Myristica fragrans HOUTT. on melanogenesis and its related enzymes such as tyrosinase, tyrosinase-related protein-1 (TRP-1), and tyrosinase-related protein-2 (TRP-2) in melan-a murine melanocytes. The IC 50 values of macelignan for melanogenesis and tyrosinase were 13 μM and 30 μM, respectively, while those of arbutin as a positive control were 990 μM and 660 μM, respectively. In Western blot analysis, macelignan also significantly decreased tyrosinase, TRP-1, and TRP-2 protein expression. These results indicate that macelignan effectively inhibits melanin biosynthesis and thus could be employed as a new skin-whitening agent.
AB - The aim of this study was to investigate the in vitro inhibitory effects of macelignan isolated from Myristica fragrans HOUTT. on melanogenesis and its related enzymes such as tyrosinase, tyrosinase-related protein-1 (TRP-1), and tyrosinase-related protein-2 (TRP-2) in melan-a murine melanocytes. The IC 50 values of macelignan for melanogenesis and tyrosinase were 13 μM and 30 μM, respectively, while those of arbutin as a positive control were 990 μM and 660 μM, respectively. In Western blot analysis, macelignan also significantly decreased tyrosinase, TRP-1, and TRP-2 protein expression. These results indicate that macelignan effectively inhibits melanin biosynthesis and thus could be employed as a new skin-whitening agent.
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U2 - 10.1248/bpb.31.986
DO - 10.1248/bpb.31.986
M3 - Article
C2 - 18451531
AN - SCOPUS:44349115020
VL - 31
SP - 986
EP - 989
JO - Biological and Pharmaceutical Bulletin
JF - Biological and Pharmaceutical Bulletin
SN - 0918-6158
IS - 5
ER -