Inhibitory effects of macelignan isolated from Myristica fragrans Houtt. on melanin biosynthesis

Yumi Cho; Kyu Hoi Kim; Jae Seok Shim; Jae Kwan Hwang

doi:10.1248/bpb.31.986

Inhibitory effects of macelignan isolated from Myristica fragrans Houtt. on melanin biosynthesis

Yumi Cho, Kyu Hoi Kim, Jae Seok Shim, Jae Kwan Hwang

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

The aim of this study was to investigate the in vitro inhibitory effects of macelignan isolated from Myristica fragrans HOUTT. on melanogenesis and its related enzymes such as tyrosinase, tyrosinase-related protein-1 (TRP-1), and tyrosinase-related protein-2 (TRP-2) in melan-a murine melanocytes. The IC ₅₀ values of macelignan for melanogenesis and tyrosinase were 13 μM and 30 μM, respectively, while those of arbutin as a positive control were 990 μM and 660 μM, respectively. In Western blot analysis, macelignan also significantly decreased tyrosinase, TRP-1, and TRP-2 protein expression. These results indicate that macelignan effectively inhibits melanin biosynthesis and thus could be employed as a new skin-whitening agent.

Original language	English
Pages (from-to)	986-989
Number of pages	4
Journal	Biological and Pharmaceutical Bulletin
Volume	31
Issue number	5
DOIs	https://doi.org/10.1248/bpb.31.986
Publication status	Published - 2008 May

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmaceutical Science

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abstract = "The aim of this study was to investigate the in vitro inhibitory effects of macelignan isolated from Myristica fragrans HOUTT. on melanogenesis and its related enzymes such as tyrosinase, tyrosinase-related protein-1 (TRP-1), and tyrosinase-related protein-2 (TRP-2) in melan-a murine melanocytes. The IC 50 values of macelignan for melanogenesis and tyrosinase were 13 μM and 30 μM, respectively, while those of arbutin as a positive control were 990 μM and 660 μM, respectively. In Western blot analysis, macelignan also significantly decreased tyrosinase, TRP-1, and TRP-2 protein expression. These results indicate that macelignan effectively inhibits melanin biosynthesis and thus could be employed as a new skin-whitening agent.",

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AU - Shim, Jae Seok

AU - Hwang, Jae Kwan

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