TY - JOUR
T1 - Inhibitory effects of plant extracts on tyrosinase activity and melanin synthesis
AU - Park, Hyen Joo
AU - Park, Kwang Kyun
AU - Hwang, Jae Kwan
AU - Chung, Won Yoon
AU - Lee, Seung Eun
AU - Lee, Sang Kook
PY - 2010/6
Y1 - 2010/6
N2 - In order to develop a new skin whitening agent, approximately 100 plant extracts were evaluated for their inhibitory activities against melanin biosynthesis in cultured mouse melanocyte melan-a cells. As a result, seven extracts exhibited over 50% inhibition of melanin synthesis compared to control at a concentration of 20 μg/ml. In particular, Aster ageratoides Turcz. van ageratoides (branch, root, aerial, flower; IC50 = 17.3, 6.1, 13.6, 12.9 μg/ml, respectively) and Physalis alkekengi var. francheti (leaf, unripen fructus, aerial; IC50 = 6.5, 28.3, 23.9 μg/ml) markedly inhibited melanin synthesis. In addition, tyrosinase activity was monitored by the measurement of dopachrome formation from the oxidation of L-3,4-dihydroxyphenylalanine. Extracts of A. ageratoides Turcz. var. ageratoides (flower) and P. alkekengi var. francheti (leaf) showed the most potent tyrosinase inhibitory activity. These plants might be the potential candidate sources in the development of novel skin-whitening products.
AB - In order to develop a new skin whitening agent, approximately 100 plant extracts were evaluated for their inhibitory activities against melanin biosynthesis in cultured mouse melanocyte melan-a cells. As a result, seven extracts exhibited over 50% inhibition of melanin synthesis compared to control at a concentration of 20 μg/ml. In particular, Aster ageratoides Turcz. van ageratoides (branch, root, aerial, flower; IC50 = 17.3, 6.1, 13.6, 12.9 μg/ml, respectively) and Physalis alkekengi var. francheti (leaf, unripen fructus, aerial; IC50 = 6.5, 28.3, 23.9 μg/ml) markedly inhibited melanin synthesis. In addition, tyrosinase activity was monitored by the measurement of dopachrome formation from the oxidation of L-3,4-dihydroxyphenylalanine. Extracts of A. ageratoides Turcz. var. ageratoides (flower) and P. alkekengi var. francheti (leaf) showed the most potent tyrosinase inhibitory activity. These plants might be the potential candidate sources in the development of novel skin-whitening products.
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M3 - Article
AN - SCOPUS:79955009422
SN - 1226-3907
VL - 16
SP - 133
EP - 139
JO - Natural Product Sciences
JF - Natural Product Sciences
IS - 2
ER -